Competition restriction

Granting agencies Personal Cash awarded Few, competitive, restricted regarding use... 

Although ASTM specifies certain quaUty levels, there are a number of factors that contribute to other quaUty levels in the marketplace. At times, government regulations are more restrictive than ASTM specifications, especiaHy with respect to environmental issues. Secondly, competitive forces may encourage companies to provide fuel quaUty that is better than that defined by ASTM. Thirdly, ASTM specifications do not have the force of law, and certain companies may decide to exceed or not meet their recommended values. In response to this last factor, some states have adopted ASTM fuel quahty specifications as state regulations, thus forcing a minimum quaUty level in the field. 

Etom the customer s point of view, there is an optimal level of standardization. Increased standardization lowers costs but restricts choice. Furthermore, if a single minimal performance product standard is rigorously invoked in an industry, competition in a free market ultimately may lead the manufacturer of a superior product to save costs by lowering his product quaHty to the level of the standard, thus denying other values to the customer. Again, excessive standardization, especially as appHed to design or how the product performance is to be achieved, effectively can limit technological innovation. 

Some of the restrictions on the use of aluminum are caused by manufacturing and fabrication problems and by its low mechanical strength. However, aluminum is widely used and is competitive with Type 316 stainless steel in many instances. The explosion-bonding process has made the aluminum cladding of steel practical, and... 

Direct photochemical excitation of unconjugated alkenes requires light with A < 230 nm. There have been relatively few studies of direct photolysis of alkenes in solution because of the experimental difficulties imposed by this wavelength restriction. A study of Z- and -2-butene diluted with neopentane demonstrated that Z E isomerization was competitive with the photochemically allowed [2tc + 2n] cycloaddition that occurs in pure liquid alkene. The cycloaddition reaction is completely stereospecific for each isomer, which requires that the excited intermediates involved in cycloaddition must retain a geometry which is characteristic of the reactant isomer. As the ratio of neopentane to butene is increased, the amount of cycloaddition decreases relative to that of Z E isomerization. This effect presumably is the result of the veiy short lifetime of the intermediate responsible for cycloaddition. When the alkene is diluted by inert hydrocarbon, the rate of encounter with a second alkene molecule is reduced, and the unimolecular isomerization becomes the dominant reaction. 

In a general concept of a symmetry-restricted anharmonic theory Krumhansl relates the phonon anomalies to the electron band topology. The latter is directly determined by the competition of nearest neighbour interactions which in turn can be a function of stress, composition and temperature Nagasawa, Yoshida Makita simulated the <110> ... 

Oil Muds. Oil-base muds can be used effectively to minimize the corrosion-related problems in drilling operations. These fluids are composed of a continuous oil phase in which water is emulsified. The performance of oil-base mud is very competitive with that of water-base muds, and is superior under some adverse conditions. However, as pointed out earlier, they are only used in special cases due to their high costs and environmental restrictions. Nevertheless, they are the most effective method to avoid corrosion-related problems. 

Nevertheless, RR is clearly a non-competitive antagonist that blocks the channel pore [2] with no effect on [ H]RTX binding [4]. RR was useful in dissecting responses mediated by capsaicin-sensitive nerves in vitro, but its use in animals was severely restricted by the toxicity (e.g. convulsive activity) that it caused [1]. 

The study of how fluids interact with porous solids is itself an important area of research [6], The introduction of wall forces and the competition between fluid-fluid and fluid-wall forces, leads to interesting surface-driven phase changes, and the departure of the physical behavior of a fluid from the normal equation of state is often profound [6-9]. Studies of gas-liquid phase equilibria in restricted geometries provide information on finite-size effects and surface forces, as well as the thermodynamic behavior of constrained fluids (i.e., shifts in phase coexistence curves). Furthermore, improved understanding of changes in phase transitions and associated critical points in confined systems allow for material science studies of pore structure variables, such as pore size, surface area/chemistry and connectivity [6, 23-25],... 

The extraordinary complexity of human genes and their products has encouraged the development of extremely high-resolution analytical methods.75 Capillary electrophoresis is competitive with slab gel methods, with resolution up to the order of about 1,000 base pairs for sequencing, sizing, and detection of mutation. Reversed phase HPLC is useful for restriction digest mapping and MALDI-MS up to about 1000 base pairs. 

Therapeutic lifestyle changes should be the first approach tried in all patients (Table 9—7).3 An adequate trial of TLC should be employed in all patients, but pharmacotherapy should be instituted concurrently in higher-risk patients. This includes dietary restrictions of cholesterol and saturated fats as well as regular exercise and weight reduction. In addition, therapeutic options to enhance LDL cholesterol lowering such as consumption of plant stanols/sterols (which competitively inhibit incorporation of cholesterol into micelles) and dietary fiber should be encouraged. These therapeutic options collectively may reduce LDL cholesterol by 20% to 25%. 

If we consider only a few of the general requirements for the ideal polymer/additive analysis techniques (e.g. no matrix interferences, quantitative), then it is obvious that the choice is much restricted. Elements of the ideal method might include LD and MS, with reference to CRMs. Laser desorption and REMPI-MS are moving closest to direct selective sampling tandem mass spectrometry is supreme in identification. Direct-probe MS may yield accurate masses and concentrations of the components contained in the polymeric material. Selective sample preparation, efficient separation, selective detection, mass spectrometry and chemometric deconvolution techniques are complementary rather than competitive techniques. For elemental analysis, LA-ICP-ToFMS scores high. 

The chemical process industries are competitive, and the information that is published on commercial processes is restricted. The articles on particular processes published in the technical literature and in textbooks invariably give only a superficial account of the chemistry and unit operations used. They lack the detailed information needed on reaction kinetics, process conditions, equipment parameters, and physical properties needed for process design. The information that can be found in the general literature is, however, useful in the early stages of a project, when searching for possible process routes. It is often sufficient for a flow-sheet of the process to be drawn up and a rough estimate of the capital and production costs made. 

Within the realm of physical reality, and most important in pharmaceutical systems, the unconstrained optimization problem is almost nonexistent. There are always restrictions that the formulator wishes to place or must place on a system, and in pharmaceuticals, many of these restrictions are in competition. For example, it is unreasonable to assume, as just described, that the hardest tablet possible would also have the lowest compression and ejection forces and the fastest disintegration time and dissolution profile. It is sometimes necessary to trade off properties, that is, to sacrifice one characteristic for another. Thus, the primary objective may not be to optimize absolutely (i.e., a maxima or minima), but to realize an overall pre selected or desired result for each characteristic or parameter. Drug products are often developed by teaching an effective compromise between competing characteristics to achieve the best formulation and process within a given set of restrictions. 

The databases we use in this study do not allow us to identify which companies market each product. This information constraint makes it impossible to compare competition between laboratories, and we are forced to restrict our analysis to competition between drugs. Hence, this work does not analyse the strategic behaviour of firms that market a series of pharmaceuticals in each of the therapeutic or generic markets. 

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