Comparisons of Analytical Methods

For both methods (A, B), a calibration should be carried out in matrix-free solution over a defined working range, in order to be able to establish the procedural characteristic data (SxoA the determination 

The F-test is used to check whether the two procedural standard deviations 

They differ if the test quantity PG is greater than the comparative value listed in the table for the F distribution (P = 99 %). 

If the influence of matrices is to be examined, 10 parallel analyses should be made from 3 real samples with different concentration levels. This should be done for both methods for the matrix-free calibration function and for the calibration function of the standard addition, making a total of 4 series. 

The multiple analyses are checked for mavericks using the Grubbs technique. The homogeneity of the variances is also tested. Finally, the mean values 

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Hewitt AD, Miyares PH, Leggett DC, et al. 1992. Comparison of analytical methods for determination of volatile organic compounds in soils. Environmental Science and Technology 26 1932-1938. 

Table 2. Comparison of analytical methods for U-series nuclides... 

Ruthenberg, K. (1997). Historical development and comparison of analytical methods for the identification of tars and pitches. In Proceedings of the First International Symposium on Wood Tar and Pitch, Biskupin, Poland, ed. Brzezinski, W. and Piotrowski, W., State Archaeological Museum in Warsaw, Warsaw, pp. 173-179. 

The essential question in the inter-comparison of analytical methods is, If the same sample (or a set of identical aliquots of a sample) is analysed by the same method in different laboratories, are the results obtained the same within the limits of experimental error . It is apparent, therefore, that the selection of an appropriate sample or samples is critical to this question and that the sampling stage should be carried out by a skilled sampler with an understanding of the overall context of the analysis and trial. 

Comparison of Analytical Methods for Trace Quantities of 2,4,6-Trinitrotoluene , JAmlnd-HygAssoc 36 (7), 497-502 (1975) 108) C. 

Reville, W. J. and Fox, P. F. (1978). Soluble protein in Cheddar cheese A comparison of analytical methods. Irish J. Food Sci. Technol. 2, 67-76. 

Hardin ED, Hayes DA, Shore FL, et al. 1989. A comparison of analytical methods for the analysis of chlorinated dioxin/dibenzofuran in pyrolyzed transformer oil samples. Chemosphere 18 1093-1100. 

Neamfug L. Comparison of Analytical Methods of Starch Content and Determination of Non-starch Saccharides Content in Cassava and Sweet Potato [M.S. Thesis], Bangkok, Thailand Kasetsart University 2001. 

Wade et al. reported the use of a novel statistical approach for the comparison of analytical methods to measure angiotensin converting enzyme [peptidyl-dipeptidase A] activity, and to measure enalaprilat and benazeprilat [8]. Two methods were used to measure peptidyl-dipeptidase A, namely hippuryl histidyl leucine (HHL-method) [9], and inhibitor binding assay (IBA method) [10]. Three methods were used to measure enalaprilat, namely a radioimmunoassay (RIA) method [11], the HHL method, and the IBA method. Three methods were used to measure benazeprilat (then active metabolite of benazepril) in human plasma, namely gas chromatography-mass spectrometry (GC-MS method) [12], the HHL method, and the IBA method, and were statistically compared. First, the methods were compared by the paired t test or analysis of variance, depending on whether two or three different methods were under comparison. Secondly, the squared coefficients of variation of the... 

Bendicho, S., Trigueros, M.C., Hernandez, T., Martin, O. 2001. Validation and comparison of analytical methods based on the release of / -nitrophenol to determine lipase activity in milk. J. Dairy Sci. 84, 1590-1596. 

Regarding laboratory controls, a review of laboratory notebooks and chromatograms should be done to check the reliability and authenticity of the supporting data in the methods development and testing of the clinical, bio, and stability batches. Reference standards used should be certified as standards. The FDA expects that, for bulk substances, the suitability of reference standards should be more extensive than that of bulk drug substance specifications. A comparison of analytical methods and specifications for lots of drug substance used in clinical batches and biobatches should be performed to see if any deletions or revisions to any specifications occurred. 

Table I. Comparison of Analytical Methods against NBS Standard Reference Material, No. 1645, River Sediments...

Figure 6.1 Advertising brochure A comparison of analytical methods" (Baird Atomic, 1959, pp. 2-3).

The brochure is a single fold-out, two pages wide. The comparison of analytical methods runs across the inner two pages. The back page consists of a series of quotes from satisfied customers, all speaking to cost ... 

TABLE 9.5 Comparison of Analytical Methods for the Determination of Total Protein Concentration... 

TABLE 2—Comparison of analytical methods using ICP-AES to determine elements in... 

Samples of crude oil are acquired at locations immediately upstream of refinery tank farms and analyzed for total mercury concentration (THg). Data are generated in the form of total mercury concentration in liquid aliquots (THg, pg/kg) of market-named oil streams obtained at particular points in time. The project is divided into three parts. Part 1 involved comparison of analytical methods and has been reported previously [1]. Part 2 involved investigation of sampling and analysis procedures and is reported here. Part 3 is in progress and involves sampling and analysis of the majority of crude oils processed in the U.S. in years 2003-2005. 

Table 3 Comparison of analytical methods for elemental analysis after combustion...

Source Mclnnes, D.A. and Longsworth, L.G., A Comparison of Analytical Methods for the Determination of Uranium, Rockefeller Institute for Medical Research, Oak Ridge, TN, 1942, MDDC-910 (declassified 1947). 

Kempf M, Wittig M, Reinhard A, von der Ohe K, Blacquiere T, Raezke K-P, Michel R, Schreier P, Beuerle T (2011) Pyrrolizidine alkaloids in honey comparison of analytical methods. Food Addit Contam A 28 332-347... 

Table 22, Comparison of Analytical Methods for Determination of Decaborane... 

H. Tuovinen, D. Vesterbacka, E. Pohjolainen, D. Read, D. Solatie and J. Lehto, A comparison of analytical methods for determining uranium and thorium in ores and mill tailings. J. Geochem. Exploration, 2014, in press. 

A COMPARISON OF ANALYTICAL METHODS FOR SCREENING GROSS ALPHA AND BETA RADIOACTIVITY IN WATER BY LIQUID SCINTILLATION COUNTING AND GAS FLOW PROPORTIONAL COUNTING... 

A Comparison of Analytical Methods for Screening Gross Alpha and Beta Radioactivity... 

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