Collaborative Drug Discovery

I. Collaborative Drug Discovery, Inc. http //www.collaborativedrug.com/ (for full disclosure two of the authors were involved in the development of this technology). 

Molecular Databank Collaborative Drug Discovery 115 http //www.collaborativedrug.com/... 

CDD Collaborative Drug Discovery Repository of small-molecule libraries of more than 300,000 compounds derived from patents, literature, and high-throughput screening data shared by academic and pharmaceutical laboratories tested against M. tuberculosis preliminary public antimalarial database from multiple sources on 30,000 public compounds (https //www.collaborativedrug.com/pages/public access)... 

The broad goals of Collaborative Drug Discovery (CDD) are to enable a collaborative cloud-based tool to be used to bring together neglected disease researchers and other researchers from usually separate areas, to collaborate and to share compounds and drug discovery data in the research community, which will ultimately result in long-term improvements in the research enterprise and health care delivery. This chapter briefly introduces CDD software and describes applications in antimalarial and tuberculosis research. 

Key words Collaborative Drug Discovery, Malaria, Tuberculosis, Neglected diseases... 

CDD has been funded by the Bill and Melinda Gates Foundation (BMGF) which has enabled them to build strong relationships with the TB pilot labs and also build the Collaborative Drug Discovery Tuberculosis Database (CDD TB DB, accessed at http //www.collaborativedrug.com/register). We have also... 

The CDD TB database is funded by the Bill and Melinda Gates Foundation (Grant 49852 Collaborative drug discovery for TB through a novel database of SAR data optimized to promote data archiving and sharing ). 

Key words Bayesian models, Collaborative Drug Discovery Tuberculosis database, Docking, Mycobacterium tuberculosis, Quantitative structure-activity relationship, Tuberculosis... 

Ekins S, Hohman M, Bunin BA (2011) Pioneering use of the cloud for development of the collaborative drug discovery (CDD) database. In Ekins S, Hupcey MAZ, Williams AJ (eds) Collaborative computational technologies for biomedical research. Wiley Hoboken, NJ... 

Barry A. Bunin Collaborative Drug Discovery, Burlingame, CA, USA Hai-Feng Chen Shanghai Jiaotong University, Shanghai, China Runsheng Chen Institute of Biophysics, Chinese Academy of Sciences,... 

A library of about 7000 natural SMs from Novartis and the Natural Product Collaborative Drug Discovery Group was screened in an attempt to discover an inhibitor of Tcf/p-catenin interaction, implicated in colorectal and other cancer types. Six potent inhibitors of microbial origin were identified and suggested for further structural refinement for cancer therapy. However, an additional screen of approximately 45,000 synthetic compounds from the Novartis collection yielded no additional inhibitors of this interaction [22]. 

Lipinski, C. Academic drug discovery The chemistry challenges of target choice and screening library selection. Collaborative Drug Discovery Community Meeting, University of California San Francisco, March 5, 2007. 

Collaborative drug discovery projects in the public domain normally focus on neglected tropical diseases (e.g., tuberculosis, malaria, and leishmaniasis) due to the evident medical need, the reduced competition, and associated intellectual property burden. The Medicines for Malaria Venture (MMV) [32] was the first to focus on malaria in a collaborative shion. MMV started in 1999 with initial funding (US 4 million) from the governments of Switzerland and the Netherlands, the UK Department for International Development, the World Bank, and the Rockefeller Foundation. 

Community-based collaborative drug discovery for neglected infectious diseases and cancer... 

Barry A. Bunin, Collaborative Drug Discovery, Inc, 1818 Gilbreth Road, Suite 220, Burlingame, CA 94403, Fax 650-522-9498... 

---