Neuropeptides peptides

The octa-peptide neuropeptide FF is generated together with a related octa-peptide (neuropeptide AF) from a... 

Type III neurotransmitters These are peptides (neuropeptides), and most are considered to be neuromodulators rather than neurotransmitters. As a further complication, some of these are also found in the intestine, where they act as local hormones or even endocrine hormones (Chapter 4 Table 14.1). 

Smaller and larger peptides ( neuropeptides ) such as substance P. somatostatin, vasopressin, corticotropin-releasing factor (CRF). neuropeptide Y or cholecystokinin (CCK). 

There are dozens of presynaptic receptors for endogenous peptides. This review will focus on receptors for four peptides or peptide families the opioid peptides, neuropeptide Y and related peptides, adrenocorticotropic hormone (corticotropin, ACTH), and the orexins. This choice is representative, since part of the receptors inhibit and part of them facilitate transmitter release moreover, the receptors under consideration are coupled to the major G proteins, namely Gl/(), Gs and Gq (Table 1). 

Allen JM, Adrian TE, Tatemoto K et al (1982) Two novel related peptides, neuropeptide Y (NPY) and peptide YY (PYY) inhibit the contraction of the electrically stimulated mouse vas deferens. Neuropeptides 3 71-7... 

Dumont, Y., Chabot, J. G., and Quirion, R. (2004). Receptor autoradiography as mean to explore the possible functional relevance of neuropeptides Focus on new agonists and antagonists to study natriuretic peptides, neuropeptide Y and calcitonin gene-related peptides. Peptides 25, 365-391. 

Other peptides which affect feeding behaviour are found in the hypothalamus. They include the orexigenic peptides neuropeptide Y (NPY) and agouti-related protein (AgRp), and the anorexic peptides melanocyte-stimulating hormone (MSH) and cocaine- and amphetamine-regulated transcript (CART) (see below). 

Dumont, Y Quirion, R. (1995) Possible Y1 receptor heterogeneity as revealed by using the newly developed non-peptide neuropeptide Y Y1 antagonist, BIBP3226. The Physiologist 38, A253. 

Hosli, L., Hosli, E., Kaeser, H. Lefkovits, M. (1992) Colocalization of receptors for vasoactive peptides on astrocytes of cultured rat spinal cord and brain stem electrophysiological effects of atrial and brain natriuretic peptide, neuropeptide Y and bradykinin. Neurosci. Lett. 148, 114-116. 

Rudolf, K., Eberlein, W., Engel, W., Wieland, H.A., Willim, K.D., Entzeroth, M., Wienen, W., Beck-Sickinger, A.G. Doods, H.N. (1994) The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist BIBP3226. Eur.J. Pharmacol. 271, R11 R13. 

Knieps, S., Michel, M.C., Dove, S. Buschauer, A. (1995) Non-peptide neuropeptide Y antagonists derived from the histamine H2 agonist arpromidine role of the guanidine group. Bioorg. Med. Chem. Lett. 5, 2065-2070. 

Jacques, D., Cadieux, A., Dumont, Y. Quirion, R. (1995) Apparent affinity and potency of BIBP 3226, a non-peptide neuropeptide Y antagonist, on purported neuropeptide Y Y1, Y2 and Y3 receptors, Eur.J. Pharmacol. 278, R3-R5. 

Distribution and processing of egg-laying peptides, neuropeptide Y, cardio active peptides, new peptides in F-cluster including Aplysia insulin, post-trans-lational modifications of R3-14 peptides in cells, peptide distribution and transport in connectives. Aplasia mytilus inhibitory-peptide-related peptides. 

VASOACTIVE INTESTINAL PEPTIDE, SUBSTANCE P, CALCITONIN GENE-RELATED PEPTIDE, NEUROPEPTIDE Y... 

Enkephalins. Term derived from the Greek enk6phalo =brain for certain oligopeptides with analgesic activity (brain peptides, neuropeptides) which were discovered in human brain tissue in 1975. Distinctions are drawn between Met -and Leu -E. H-Tyr-Gly-Gly-Phe-X-OH X = Met or Leu... 

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