Acute Motor Axonal Neuropathy AMAN

A brief discussion of peripheral nerve gangliosides is necessary for understanding the pathogenetic effects of anti-ganglioside antibodies. Gangliosides, the target antigens of 

With this background information, we outline the experimental data that supports the notion that anti-ganglioside antibodies can induce nerve fiber injury in animal models and briefly review the effects of these antibodies on nodes of Ranvier and motor nerve terminals. Two animal models that provide proof of concept that anti-ganglioside antibocUes with -GMl and -GDla specificities can induce neuropathy. 

The effects of and-ganglioside andbocly-mecUateclinjury on motor nerve terminals have been extensively examined by in vitro phrenic nerve-cUaphragm preparadons. Current 

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Figure 20.2. Proposed pathogenesis in acute motor axonal neuropathy (AMAN) In AMAN there is primary axonal injury without T-ceU inflammation and demyelination. Deposition of autoantibodies and complement on the axolemma is followed by structural axonal injury or alteration of axon conduction. Macrophages within the periaxonal space contribute to the axonal damage (B B-cell M< > Macrophage, C5b-9 complement factors).

AMAN acute motor axonal neuropathy CART cocaine- and amphetamine-regulated transcript... 

Abbreviations AMAN acute motor axonal neuropathy... 

AID AIDP AIDS AIF AIRE AIS AES AMAN AMN AMPA AMSAN activation-induced (cytidine) deaminase acute inflammatory demyelinating polyradiculoneuropathy acquired immunodeficiency syndrome apoptosis inducing factor autoimmune regulator anterior chamber associated immune deviation (ACAID)-inducing signal amyotrophic lateral sclerosis acute motor axonal neuropathy adrenomyeloneuropathy a-amino-3 -hydroxy-5-methylisoxazole- 4-propionic acid acute motor-sensory axonal neuropathy... 

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