Climbing fibres

Zhang N, Walberg F, Laake JH, Meldrum BS, Ottersen OP (1990) Aspartate-like and glutamate-like immunore-activities in the inferior olive and climbing fibre system a light microscopic and semiquantitative electron microscopic study in rat and baboon Papio anubis). Neuroscience 5S 61-80. 

Toggenburger G, Wiklund L, Henke H, Cuenod M (1983) Release of endogenous and accumulated exogenous amino acids from slices of normal and climbing fibre-deprived rat cerebellar slices. J Neurochem 47 1606-1613. 

Glutamate is a key neurotransmitter in the cerebellum mossy fibres onto granule cells parallel fibres onto Purkinje and stellate/basket cells, climbing fibres onto Purkinje cells, and also mossy fibre and climbing fibre inputs onto Golgi cells all use glutamate (Fig. 19) (Voogd... 

Purkinje cells express GluR-A flop, GluR-B flip and flop, and GluR-C flip mRNAs GluR-A expression is the weakest (Keinanen et al., 1990 Sommer et al., 1990 Monyer et al., 1991 Sato et al., 1993 see Fig. II-L for pan GluR-A to -D expression). There are thus probably multiple AMPA receptors on Purkinje cells for example, these could be differentially located at parallel fibre and climbing fibre synapses. 

Yip J, Marcon R, Kemper TL, Bauman ML, Blatt GJ (2005) The olivocerebellar projection in autism using the intermediate filament protein peiipheiin as a marker for climbing fibres. Int Meet Autism Res Abs (IMFAR) 5 49. 

Andersson G, Eriksson L (1981) Spinal, trigeminal and cortical climbing fibre paths to the lateral vermis of the cerebellar anterior lobe in the cat. Exp. Brain Res., 44, 71-81. 

Andersson G, Nyquist J (1983) Origin and sagittal termination areas of cerebro-cerebellar climbing fibre paths in the cat. J. Physiol, 337, 257-285. 

Campbell NC, Armstrong DM (1985) Origin in the medial accessory olive of climbing fibres to the x and lateral cl zones of the cat cerebellum a combined electrophysiological/WGA-HRP investigation. Exp. Brain. Res., 58, 520-531. 

Do KQ, Vollenweider FX, Zollinger M, Cuenod M (1990) Effect of climbing fibre deprivation on the K -evoked release of endogenous adenosine from rat cerebellar slices. Eur. J. Neurosci, 3, 201. 

Ekerot C-F, Larson B (1977) Three sagitlal zones in the cerebellar anterior lobe innervated by a common group of climbing fibres. Proc. Ini. Union Physiol. Set, Paris, Vol. XIII, p. 208. 

Ekerot C-F, Kano M (1985) Long-term depression of parallel fibre synapses following stimulation of climbing fibres. Brain Res., 342, 357-360. 

Ekerot C-F, Kano (1989) Stimulation parameters influencing climbing fibre induced long-term depression of parallel fibre synapses. Neurosci. Res., 6. 264-268. 

Ekerot C-F, Gustafsson P, Oscarsson O. Schouenborg J (1987) Climbing fibres projecting to cat cerebellar anterior lobe activated by cutaneous A and C fibres. J. Physiol. Land, 386, 529-538. 

Ekerot C-F, Garwicz M, Schouenborg J (1991a) Topography and nociceptive receptive fields of climbing fibres projecting to the cerebellar anterior lobe in the cat. J. Physiol, 441, 257-274. 

Garwicz M (1992) Cerebellar control of forelimb movements modular organization revealed by nociceptive and tactile climbing fibre input. Thesis, Lund. 

Garwicz M, Ekerot C-F, Schouenborg J (1992) Distribution of cutaneous nociceptive and tactile climbing fibre input to sagittal zones in cat cerebellar anterior lobe. In Cerebellar control of forelimb movements modular organization revealed by nociceptive and tactile climbing fibre input (Garwicz, Ed.). Thesis, Lund. 

Ito M, Sakurai M, Tongroach P (1982) Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells. J. Physiol, 324, 113-134. 

Jeneskog T (1974) A descending pathway to dynamic fusimotor neurones and its possible relation to a climbing fibre system. Medical Dissertation, Umea University. 

Jeneskog T (1981a) On climbing fibre projections to cerebellar paramedian lobule activated from mesencephalon in the cat. Brain Res., 211, 135- 140. 

King JS, Ho RH, Bishop GA (1986a) Anatomical evidence for enkephalin immunoreactive climbing fibres in the cerebellar cortex of the opossum. J. Neurocytol, 15, 545-559. 

Larson B, Miller S, Oscarsson O (1969b) A spinocerebellar climbing fibre path activated by the flexor reflex afferents from all four limbs, J. Physiol., 203, 641-649. 

Provini L, Redman S, Strata P (1967) Somatotopic organization of mossy and climbing fibres to the anterior lobe of cerebellum activated by the sensorimotor cortex. Brain Res., 6, 378-381. 

Rosina A, Morara S, Provini L, Forloni G (1990) Modulation of cerebellar CGRP binding sites induced by climbing fibre activation. Neuroreport, I, 215-217. 

The output of Purkinje cells is regulated by two distinct excitatory inputs, the parallel fibres and the climbing fibres. Conjunctive stimulation of parallel fibres and climbing fibres input at low frequencies results in a persistent attenuation of the parallel fibre- Purkinje neurone synapse, a process termed long-term depression (Ito et al. 1982). 

Fig. 237. Climbing fibre with long, slender mitochondria, sparse tubular endoplasmatic reticulum, numerous microtubules, and few neurofilaments. Molecular layer of the reoxygenated cerebellar cortex (block 1333) of a rat (No. 11) treated for 7 consecutive days with intraperitoneal injection of 15 mg carbocromene per kg body weight x day. On the last 4 days of the experimentation the animal was exposed to an atmosphere containing only 5 % oxygen for 30 min. On August 5, 1976 under pentobarbital anaesthesia (30 mg/kg), the animal was perfused from the abdominal aorta with 2.5 % glutaral-dehyde in 0.1 M sodium cacodylate buffer (pH 7.4). Postfixa-tion with 1 % osmium tetroxide in sodium cacodylate buffer. Embedded in Epon 812 and sectioned at 50 nm. Lead citrate and uranyl acetate. Plate 3419...

Endogenous NO is released after stimulation of climbing fibres (Shibuki and Okada 1991). Longterm depression evoked by conjunctive stimulation... 

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