Clark, Gene

Clarke PA, te Poele R, Wooster R, Workman P (2001) Gene expression microarray analysis in cancer biology, pharmacology, and drug development progress and potential. Biochem Pharmacol 62 1311-1336... 

Gough DJ, Sabapathy K, Ko EY, Arthur HA, Schreiber RD, Trapani JA, Clarke CJ, Johnstone RW (2007) A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes. J Biol Chem 282 938-946 Guidotti LG, Chisari EV (2001) Noncytolytic control of viral infections by the innate and adaptive immune response. Annu Rev Immunol 19 65-91... 

Al-Shawi R., Ghazal P., Clark J. and Bishop J.O. (1989). Intraspecific evolution of a gene family coding for urinary proteins. J Molec Evol 29, 302-313. 

Li, CM, Clark, ME, Chimento, MF, and Curcio, CA, 2006. Apolipoprotein localization in isolated drusen and retinal apolipoprotein gene expression. Invest Ophthalmol Vis Sci 47, 3119-3128. 

Caron, K. M., Soo, S. C., Wetsel, W. C., Stocco, D. M., Clark, B. J., and Parker, K. L. 1997. Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Proc. Natl. Acad. Sci. U.S.A., 94(21) 11540-11545. 

Crawford, I. P. and Milkman R. (1991), Orthologous and paralogous divergence, reticulate evolution, and lateral gene transfer in bacterial trp genes , in R. K. Selander, A. G. Clark and... 

Houck, M. A. Clark, J. B. Peterson, K. R. and Kidwell, M. G. (1991), Possible horizontal transfer of Drosophila genes by the mite Protolaelaps regalis , Science, 254, 1125-1129-... 

Bishop, J. O., Clark, A. J., Qissold, P. M., Hainey, S. and Francke, U. (1982) Two main groups of mouse major urinary protein genes, both largely located on chromosome 4. EMBO J. 1,615-20. 

Murphy M, Ahn J, Walker KK (1999) Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev 13 2490-2501 Nakajima H, Kim YB, Terano H, Yoshida M, Horinouchi S (1998) FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor. Exp Cell Res 241(1) 126-133 Nebbioso A, Clarke N, Voltz E, Germain E, Ambrosino C, Bontempo P, Alvarez R, Schiavone EM, Eerrara F, Bresciani F, Weisz A, de Lera AR, Gronemeyer H, Altucci L (2005) Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells. Nature Med 11 77-84... 

MacKenzie SM, Clark CJ, Fraser R, Gomez-Sanchez CE, Connell JM, et al. 2000. Expression of 1 Ibeta-hydroxylase and aldosterone synthase genes in the rat brain. J Mol Endocrinol 24 321-328. 

Clark JC, Wert SE, Bachurski CJ, et al. Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. Proc Natl Acad Sci USA 1995 92(17) 7794 7798. 

Eullerton, S.M., Clark, A.G., Weiss, K.M., et al. (2002) Sequence polymorphism at the human apolipoprotein All gene (APOA2) unexpected deficit of variation in an African-American sample. Hum. Genet., Ill, 75-87. 

Caskey CT, Forrester WC, Tate W (1984) Peptide chain termination. In Clark BFC, Petersen HU (eds) Gene expression the translational step and its control. Munksgaard, Copenhagen... 

Hirschhorn, J.N., Brown, S.A., Clark, C.D., and Winston, F. (1992) Evidence that SNF2/SWI2 and SNF5 activate transcription in yeast by altering chromatin structure. Genes Dev. 6, 2288-2298. 

Sternberg, P.W., Stern, M.J., Clark, I., and Herskowitz, I. (1987) Activation of the yeast HO gene by release from multiple negative controls. Cell 48, 567-577. 

Davis T, Kennedy C, Chiew YE, Clarke CL, deEaxio A. (2000) Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells. Clin Cancer Res 6 4334 342. 

Some argue that it is a waste of time to monitor gene expression when ultimately we desire the end product, the protein target. More likely both aspects are needed to further expand our understanding of cellular events (Clarke et al., 2001). All of these pro-vs.-con arguments may sound quite... 

---