Genes major urinary proteins

Held W., Gallagher J.F., Hohman C.M., Kuhn N.J., et al. (1987). Identification and characterization of functional genes encoding the mouse major urinary proteins. Mol Cell Biol 10, 3705-3712. 

Shaw P., Held W. and Hastie N. (1983). The gene family for major urinary proteins, expression in several secretory tissues of the mouse. Cell 32, 755-761. 

Utsumi M., Ohno K., Kawasaki Y., Tamura M., et al. (1999). Expression of major urinary protein genes in the nasal glands associated with general olfaction. J Neurobiol 39, 227-236. 

Bennett, K. L., Lalley, P. A., Barth, R. K. and Hastie, N. D. (1982) Mapping the structural genes coding for the major urinary proteins in the mouse combined use of recombinant inbred strains and somatic cell hybrids. Proc. Natl. Acad. Sci. USA 79, 1220-4. 

Bishop, J. O., Clark, A. J., Qissold, P. M., Hainey, S. and Francke, U. (1982) Two main groups of mouse major urinary protein genes, both largely located on chromosome 4. EMBO J. 1,615-20. 

Shahan, K., Denaro, M., Gilmartin, M., Shi, Y. and Derman, E. (1987) Expression of six mouse major urinary protein genes in the mammary, parotid,sublingual, submaxillary, and lachrymal glands and in the liver. Mol. Cell. Biol. 7, 1947-1954. 

Clark, A. J., Ghazal, P., Bingham, R. W., Barrett, D., and Bishop, J. O., 1985, Sequence structures of a mouse major urinary protein gene and pseudogene compared, 4 3159-3165. 

The urinary scents of wild house mice provide each individual with a unique olfactory signature. Two highly polymorphic gene clusters appear to provide the main basis for individuality scents in mice the major histocompatibility complex (MHC) and the major urinary proteins (MUPs) (see Thom et al. and Hurst et al., this volume). These... 

The major urinary proteins (MUPs) are secreted abundantly into mouse urine as a normal condition. MUPs are thought to be involved in olfactory communication as their distinctive barrel shape allows them to bind two semiochemical molecules. Production of MUPs results from simultaneous expression of a number of closely related MUP genes the mature proteins therefore have heterogeneous amino acid sequences. Whilst this heterogeneity has been characterised in inbred mice, little is known about the heterogeneity of MUPs in wild mice. No function has ever been ascribed to MUP heterogeneity. 

Hastie, N. D., Held, W. A. and Toole, J. J. 1979. Multiple genes coding for the androgen regulated major urinary proteins of the mouse. Cell, 17, 449-457. 

Knopf, J. L., Gallagher, J. K. and Held, W. A. 1983. Differential multihormonal regulation of mouse major urinary protein gene family in the liver. Mol. Cell. Biol, i, 2232—2240. 

There are two major forms of hereditary susceptibility to colon cancer.00 Familial adenomatous polyposis is caused by defects in the APC gene (see Chapter 32). The more common hereditary nonpolyposis colorectal cancer (HNPCC), which includes many endometrial, stomach, and urinary tract tumors, results from defects in DNA mismatch repair. -)) The proteins hMSH2 and hMSLl are homologs of the E.coli MutS and MutL (main text). 

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