Steroidogenic acute regulatory protein

DHT Dihydrotestosterone StAR Steroidogenic acute regulatory (protein)... 

CBP is predicted by PSORT analysis to be a cytoplasmic protein (Horton et al. 2007) and to contain a steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain of 200 amino acids at its C-terminus (Figure 24.2a). 

Alpy, F., Stoeckel, M. E., Dierich, A. et al. 2001. The steroidogenic acute regulatory protein homolog MLN64, a late endosomal cholesterol-binding protein. J. Biol. Chem., 276(6) 4261-4269. 

Caron, K. M., Soo, S. C., Wetsel, W. C., Stocco, D. M., Clark, B. J., and Parker, K. L. 1997. Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Proc. Natl. Acad. Sci. U.S.A., 94(21) 11540-11545. 

Miller, W. L. 2007. Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter. Biochim. Biophys. Acta, 1771(6) 663-676. 

An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain. J Neurosci 22 10613-10620. 

In the animal body three important groups of hormones are formed by the metabolism of cholesterol the progestins, the sex hormones, and the adrenal cortical hormones 249 Their synthesis occurs principally in mitochondria of the adrenal cortex and the gonads. Steroid hormone synthesis is regulated by hormones, such as corticotropin (ACTH), from the anterior pituitary250 (see Chapter 30) and is also dependent upon the recently discovered steroidogenic acute regulatory protein, which in some way promotes the movement of stored cholesterol into mitochondrial membranes.251 252 Some major pathways of... 

Kohen P, Castro O, Palomino A, et al. The steroidogenic response and corpus luteum expression of the steroidogenic acute regulatory protein after human chorionic gonadotropin administration at different times in the human luteal phase. J Clin Endocrinol Metab. 2003 88 3421-3430. 

Lin D, SugawaraT, Strauss JF 3rd, et al. Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 267 1821-... 

Tuckey RC, Headlam MJ, Bose HS, Miller WL Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein (StAR). f Biol Chem 277 47123-47128,2002. 

The initial rate limiting step in the transport of intracellular cholesterol to sites of steroidogenesis is mediated by a steroidogenic acute regulatory protein (StAR) that is regulated by adrenocorticotropic hormone (ACTH). 

Kusakabe, M., T. Todo, H.J. McQuillan, F.W. Goetz and G. Young. Characterization and expression of steroidogenic acute regulatory protein and MLN64 cDNAs in trout. Endocrinology 143 2062-2070, 2002. 

Walsh, L.P. and D.M. Stocco. Effects of lindane on steroidogenesis and steroidogenic acute regulatory protein expression. Biol. Reprod. 63 1024-1033, 2000. 

Clark, B. J., and Combs, R. (1999). Angiotensin II and cyclic adenosine 3 ,5 -monophosphate induce human steroidogenic acute regulatory protein transcription through a common steroidogenic factor-1 element. Endocrinology 140, 4390-4398. 

Clem, B. F., Hudson, E. A., and Clark, B. J. (2005). Cyclic adenosine 3 ,5 -monophosphate (cAMP) enhances cAMP-responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic acute regulatory protein gene promoter. Endocrinology 3, 1348-1356. 

Necrosis Factor- alpha and Ceramide Directly Abrogates Steroidogenic Acute Regulatory Protein Expression and Leydig Cell Steroidogenesis in Adult Rats. Endocrinology 144, 4763 772. 

Ramnath, H. I., Peterson, S., Michael, A. E., Stocco, D. M., and Cooke, B. A. (1997). Modulation of steroidogenesis by chloride ions in MA-10 mouse tumor Leydig cells roles of calcium, protein synthesis, and the steroidogenic acute regulatory protein. Endocrinology 138, 2308-2314. 

Choi, Y. S., Stocco, D. M., and Freeman, D. A. (1995). Dieillyluinbelliferyl phosphate inhibits stcroidogene.si.s by interfering with a long-lived factor acting between protein kinase A activation and induction of the steroidogenic acute regulatory protein (StAR). Eur. J. Biochem. 234, 680-685. 

LIO. Liu, K., Feng, Q., Gao, H. J., et al.. Expression and regulation of plasminogen activators, plasminogen activator inhibitor type-1, and steroidogenic acute regulatory protein in rhesus monkey corpus luteum. Endocrinology 144, 3611-3617 (2003). 

StAR protein Steroidogenic acute regulatory protein... 

Potential modes of action of lead reproductive toxicity include disraption of the hypothalamic-pituitaiy-gonadal axis through reduced luteinizing hormone secretion and reduction in the expression of the steroidogenic acute regulatory protein (Crain et al. 2008 EPA 2012). Lead may also interfere with cation-dependent secondary messenger systems that mediate pituitary hormone release... 

Arakane E, King SR, Du Y, Kallen CB, Walsh LP, Watari H., Stocco DM, Strauss JF III (1997) Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity. J Biol Chem 272 32656-32662... 

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