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Cis-dichlorodiammineplatinum

Yatvin, M. B., Miihlensiepen, H., Porschen, W., Weinstein, J. N., and Feinendegen, L. E. (1981). Selective delivery of liposome-associated cis-dichlorodiammineplatinum(II) by heat and its influence on tumor drug uptake and growth. Cancer Res.. 41. 1602-1607. [Pg.338]

Cis-DiCHLORODiAMMiNEPLATiNUM (II) (cisplatin, CDDP) has been widely used for clinical cancer therapy in spite of its severe renal toxicity [1] and low water-solubility. [Pg.243]

Howie JA. Gale GR. Cis-dichlorodiammineplatinum (II). Persistent and selective inhibition of deoxyribonucleic acid synthesis in vivo. Biochem Pharmacol 1970 19(10) 2757-2762. [Pg.57]

Douple EB, Richmond RC, Logan ME. Therapeutic potentiation in a muse mammary tumor and an intracerebral rat brain tumor by combined treatment with cis-dichlorodiammineplatinum (II) and radiation. J Clin Hematol Oncol 1977 7 585-603. [Pg.58]

Richmond RC, Zimbrick JD, Hykes DL. Radiation-induced DNA damage and lethality in e-coli as modified by the antitumor agent cis-dichlorodiammineplatinum (II). Radiat Res 1977 71 447. [Pg.59]

Kovacs CJ, Schenken LL, Burholt DR. Therapeutic potentiation of combined cis-dichlorodiammineplatinum (11) and irradiation by ICRF-159. Int J Radiat Oncol Biol Phys 1979 5 1361-1364. [Pg.59]

FACILE SYNTHESIS OF ISOMERICALLY PURE cis-DICHLORODIAMMINEPLATINUM(II), CISPLA TIN... [Pg.141]

Nishiyama, N., Yokoyama, M., Aoyagi, T., Okano, T., Sakurai, Y. and Kataoka, K. (1999) Preparation and characterization of self-assembled polymer-metal complex micelle from cis-dichlorodiammineplatinum(II) and poly(ethylene glycol)-poly(, -aspartic acid) block copolymer in an aqueous medium. Langmuir, 15, 377-383. [Pg.169]

Fig. 5. The effects of cis-dichlorodiammineplatinum(II) on macromolecular syntheses in human amniotic cells in tissue culture at a concentration (5 pM = 1 ppm) similar to that found in tumor cells in animals treated with a therapeutic dose of the drug. DNA Synthesis is measured by the incorporation of radioactively labeled thymidine and is severely and persistently inhibited. The synthesis of RNA, measured by radioactive uridine, and protein, measured by radioactive leucine is not significantly different from control (nontreated) cells represented by the horizontal bar at 1.00. Fig. 5. The effects of cis-dichlorodiammineplatinum(II) on macromolecular syntheses in human amniotic cells in tissue culture at a concentration (5 pM = 1 ppm) similar to that found in tumor cells in animals treated with a therapeutic dose of the drug. DNA Synthesis is measured by the incorporation of radioactively labeled thymidine and is severely and persistently inhibited. The synthesis of RNA, measured by radioactive uridine, and protein, measured by radioactive leucine is not significantly different from control (nontreated) cells represented by the horizontal bar at 1.00.
Ritch PS. Cis-dichlorodiammineplatinum Il-induced syndrome of inappropriate secretion of antidiuretic hormone. Cancer 1988 61(3) 448-50. [Pg.2867]

Cavalli F, Tschopp L, Sonntag RW, Zimmermann A. A case of liver toxicity following cis-dichlorodiammineplatinum(II) treatment. Cancer Treat Rep 1978 62(12) 2125-6. [Pg.2870]

Cvltkovic B, Spaulding J, BethuneV, Martin J, Whitemore WF. Improvement of cis-dichlorodiammineplatinum therapeutic index in an animal model. Cancer 1977 39 1357-61. [Pg.528]

Boven E,VanderVijghWJE, Nauta MM, SchluperHMM,PinedoHM. Comparative activity and distribution studies of five platinium analogues in nude mice bearing human ovarian carcinoma xenografts. Cancer Research, 45 86-90,1985 Gormley PE, Bull JM, EeRoy AF, Cysyk R. Kinetics of cis-dichlorodiammineplatinum. Clin Pharmacol Then 1979 Mar 25[3] 351-7 SiddikZH, Jones M, Boxall FE, Harrap KR. Comparative distribution and excretion of carboplatin and cisplatin in mice Cancer Chemother Pharmacol. 1988 21 [1 ] 19-24... [Pg.529]

Cisplatin (cis-dichlorodiammineplatinum cisDDP) belongs to one of the most frequently explored platinum compounds since Rosenberg s discovery of its anticancer activities.1 It was found that cisplatin makes a bridge connection between two (usually) adjacent guanine bases in DNA predominately forming 1,2-intrastrand GpG complexes (about 65% of the occurrences). Some other intrastrand coordinations occur less frequently, namely with the l,2-d(ApG) and the l,3-d(GpXpG) base sequences. However, coordination to the l,2-d(ApA) or the l,2-d(GpA) fragment was observed only very rarely. [Pg.266]

Bruckner, H. W, Ratner, L. H., Cohen, C. J., Wallach, R., Kabakow, B., Greenspan, E. M., Holland, J. F Combination chemotherapy for ovarian carcinoma with cyclophosphamide, adriamycin and cis-dichlorodiammineplatinum (11) after failure of initial chemotherapy. Cancer Treat. Rep. 1978, 62, 1021-1023. [Pg.59]

Munchausen LL, Rahn RO. Biological and chemical effects of cis-dichlorodiammineplatinum [II] on DNA. Cancer Chemother Rep 1975 59 643-646. [Pg.366]

Gonzalez-Vitale JC, Hayes DM, Cvitkovic E, Sternberg SS. Acute renal failure after cis-dichlorodiammineplatinum(ll) and gen-tamicin-cephalothin therapies. Cancer Treat Rep 1978 62(5) 693-698. [Pg.367]

Gormley PE, Bull JM, LeRoy AF, Cysyk R. Kinetics of cis-dichlorodiammineplatinum. Clin Pharmacol Ther 1979 25(3) 351-357. [Pg.367]

Salem PA Jabboury KW, Khalil MF. Severe nephrotoxicity a probable conplication of cis-dichlorodiammineplatinum (II) and cephalothin-gentamicin therapy. Oncology (1982) 39,... [Pg.620]

Dumas M, d Athis P, de Gislain C, Lautissier JL, Autissier N, Escousse A, Guerrin I Influence of frusemide on cis-dichlorodiammineplatinum (E) pharmaco-kinetics. EurJDrugMe-tab Pharmacokinet ( 9S7) 12,203-6. [Pg.621]

Bahnson RR, Banner BF, Ernstoff MS, Lazo JS, Cherian MG, Banerjee D, Chin JL (1991) Immunohistochemical localization of metallothionein in transitional cell carcinoma of the bladder. J Urol 146 1518-1520 Bakka A, Endresen L, Johnsen AB, Edminson PD, Rugstad HE (1981) Resistance against cis-dichlorodiammineplatinum in cultured cells with a high content of metallothionein. Toxicol Appl Pharmacol 61 215-226 Banerjee D, Onosaka S, Cherian MG (1982) Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of rat liver and kidney. Toxicology 24 95-105... [Pg.276]

The behavior of the anticancer agent cis-dichlorodiammineplatinum (II), or cisplatin, is another example of the utility of the method . The adsorptive-stripping/cyclic voltammetric (saturation) data yield a surface coverage of 5.1 x 10- o mol/cm. Each adsorbed molecule thus occupies an area of 33 A 2. This value is in excellent agreement with the area (34 A 2) estimated from the crystal structure of cisplatin. Such agreement suggests the existence of a packed geometrically planar layer of adsorbed cisplatin at the surface. [Pg.475]

See other pages where Cis-dichlorodiammineplatinum is mentioned: [Pg.14]    [Pg.45]    [Pg.263]    [Pg.142]    [Pg.143]    [Pg.303]    [Pg.303]    [Pg.756]    [Pg.9]    [Pg.9]    [Pg.756]    [Pg.344]    [Pg.222]    [Pg.241]    [Pg.6901]    [Pg.155]    [Pg.209]    [Pg.142]    [Pg.143]    [Pg.89]    [Pg.155]   


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