Normal healing process

Recently, a superior therapy has been approved for use by the federal government tissue-type plasminogen activator (tPA). This naturally occurring enzyme dissolves blood clots as part of the normal healing process. By administering relatively large quantities of it, clot breakdown time can be shortened from about a week to under an hour. 

Wounds can be categorized as acute (healing quickly on their own) or chronic (healing slowly, and often requiring medication). Chronic wounds, such as ulcers (Table 10.9), occur if some influence disrupts the normal healing process. Such influences can include diabetes, malnutrition, rheumatoid arthritis and ischaemia (inadequate flow of blood to any part of the body). Elderly people are particularly susceptible to developing chronic wounds, often resulting in the necessity for hospitalization. Ulceration (particularly of the limbs or extremities) associated with old age,... 

Corticosteroids usually take 3 to 7 days to start to relieve pain, and they are usually injected repeatedly to speed up the process. Prolonged used of corticosteroids to relieve pain can interfere with normal healing processes, weaken tendons, cause bone density problems, and can even damage joint... 

Chronic wounds undergoing a normal healing process. 

Recent studies have reported that sirolimus reduces neointimal formation by inhibiting the proliferation and migration of VSMC and delays the normal healing processes of the injured arterial wall [147]. In the control group, poor endothehal cell junction formation (Fig. 16b) [166] and thrombus-hke substance deposition around the stent stmts (indicated by the arrow in Fig. 16b, inset) were observed at 6 weeks after implantation, possibly owing to the adverse side effects of the initial... 

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