Cholesterol randomized controlled trial

Hutchings. Instant coffee, and cholesterol a randomized controlled trial. Eur... 

A recent meta-analysis of eight randomized controlled trials of soy protein consumption in humans has found that with identical soy protein intake, high isoflavone intake led to significantly greater decreases in serum LDL cholesterol than low isoflavone intake, indicating that isoflavones have LDL-cholesterol-lowering effects that are independent of the soy protein. 

Zhuo X-G, Melby MK, Wantanabe S. Soy isoflavone intake lowers serum LDL cholesterol a meta-analysis of 8 randomized controlled trials in humans. J. Nutr. 134, 2395-2400, 2004. 

Lee JK, Grace KA, Taylor AJ, 2006. Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol A randomized, controlled trial (see Comment). JAMA 296 2563-71. 

In an analysis of the landmark randomized controlled trials, the Cholesterol Treatment Triallists Collaboration has shown a linear relationship between the reduction in cardiovascular events and amount of LDL cholesterol lowering (27), This is shown in Figure 4, For example, each I.Ommol/L reduction in LDL cholesterol was associated with a 13% reduction in all-cause mortality. More recent trials have specifically tested whether or... 

Roeback JR, Hla KM, Chambless LE, et al. 1991. Effects of chromium supplementation on serum high-density lipoprotein cholesterol levels in men taking beta-blockers A randomized, controlled trial. Ann Intern Med 115 917-924. 

Communities (ARIC) Study. Journal of the American Medical Association 279 119-124 Huxley R, Lewington S, Clarke R (2002). Cholesterol, coronary heart disease and stroke a review of puhhshed evidence from observational studies and randomized controlled trials. Seminars in Vascular Medicine 2 315-323... 

Berthold, H.K., Sudhop, T. and von Bergmann, K. (1998) Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism a randomized controlled trial. JAMA. 279 1900-1902. 

Nicholls SJ, Brewer HB, Kastelein JJ, Krueger KA, Wang MD, Shao M, Hu B, McErlean E, Nissen SE (2011) Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol a randomized controlled trial. JAMA 306 2099-2109... 

Taku, K. K. Umegaki Y. Sato Y. Taki K. Endoh S. Watanabe. Soy isoflavones lower serum total and LDL cholesterol in humans A meta-analysis of 11 randomized controlled trials. Am. J. Clin. Nutr. 2007, 85, 1148-1156. 

Sever PS, Dahlof B, Poulter NR, et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower than average cholesterol concentrations in the Anglo Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA) a multicentre randomized controlled trial. Lancet. 2003 361 1149-1158. 

A recent New Zealand randomized, controlled trial of 28 hyperlipidemic men and women [65] showed that a 30 g serving of nuts consumed daily over 6 weeks was found to be as effective as one serving of a canola oil enriched cereal at reducing total and LDL cholesterols. They concluded that since the fatty acid profiles of the nut- and canola-enriched cereals were similar, and the results were similar, the fatty acid profile is one of the major factors responsible for the beneficial effects of nuts. 

Jones ML, Martoni CJ, Prakash S. Cholesterol lowering and inhibition of sterol absorption by lactnhacillus reuteri NQMB 30242 a randomized controlled trial. Eur Clin Nutr. 2012 66 1234—1241. 

Taku, K., Umegaki, K., Ishimi, Y., and Watanabe, S. 2008. Effects of extracted soy isoflavones alone on blood total and LDL cholesterol Meta-analysis of randomized controlled trials. Iher Clin RiskManag 4, 1097-1103. 

Nguyen, TT, Dale, L, von Bergmann, K and Croghan, IT (1999) Cholesterol-lowering effect of stanol ester in a US population of mildly hypercholesterolemic men and women a randomized, controlled trial. Mayo Clin. Proc., 74, 1198-1206. 

Eleart Protection Study Collaborative Group. (2002) MRC/BHF Heart Protection study of cholesterol lowering with simvastatin in 20,506 high-risk individuals a randomized placebo-controlled trial. Lancet, 360, 7-22. 

Bokura, H. and Kobayashi, S. (2003). Chitosan decreases total cholesterol in women. A randomized, double-blind, placebo-controlled trial. Eur. J. Clin. Nutr. 57, 721-725. 

In a double-blind, randomized, placebo controlled trial of praziquantel in 42 patients with clonorchiasis and an open study in 32 patients, the adverse effects of praziquantel were transient and included nausea and vomiting (15%), vertigo (12%), hepatomegaly (4.5%), headache (1.5%), rash (1.5%), and hypotension (1.5%) (9). Of 20 patients who received placebo, one developed a transient skin rash, fever, and chills. There were minor and transient, albeit statistically significant, changes in hemoglobin and serum concentrations of total protein, uric acid, cholesterol, and bilirubin. 

Hawthorn extracts purportedly dilate coronary blood vessels, decrease blood pressure, increase myocardial contractility, and lower serum cholesterol (9). Benefits have been demonstrated in patients with heart failure (10). In patients with stage II New York Heart Association (NYHA) heart failure, doses of 160-900 mg/day of the aqueous-alcoholic extract for up to 56 days showed an increase in exercise tolerance, decrease in rate/pressure product, and increased ejection fraction (11). Degenring and colleagues, in a randomized, double-blind, placebo-controlled trial, studied a standardized extract of fresh Crataegus berries (Crataegisan ) for the treatment of patients with... 

---