Low-density lipoprotein-cholesterol

Abbtvviations apoC-lll, apolipoprotein C-lll apoA-l, apolipoprotein A-l apoA-ll, apolipoprotein A-ll CRP, C-reactive protein VLDL, very low density lipoprotein TG, triglycerides LDL-C, low density lipoprotein cholesterol HDL-C, high density lipoprotein cholesterol. 

To control risk factors and prevent major adverse cardiac events, statin therapy should be considered in all patients with ischemic heart disease, particularly in those with elevated low-density lipoprotein cholesterol. In the absence of contraindications, angiotensin-converting enzyme inhibitors should be considered in ischemic heart disease patients who also have diabetes melli-tus, left ventricular dysfunction, history of myocardial infarction, or any combination of these. Angiotensin receptor blockers... 

Increased low-density lipoprotein cholesterol, total cholesterol, triglycerides decreased high-density lipoprotein cholesterol. 

Low-density lipoprotein cholesterol greater than or equal to 160 mg/dL (4.14 mmol/L)... 

Low-density lipoprotein cholesterol greater than or equal to 130 to 159 mg/dL (3.37 to 4.12 mmol/L) plus two additional risk factors High-density lipoprotein cholesterol less than 35 mg/dL (0.91 mmol/L) Impaired fasting glucose [fasting blood glucose 100-125 mg/dL (5.6 to 6.9 mmol/L)]... 

Wang J, Freeman DJ, Grundy SM, Levine DM, Guerra R, Cohen JC. Linkage between cholesterol 7alpha-hydroxylase and high plasma low-density lipoprotein cholesterol concentrations. J Clin Invest 1998 101 1283-1291. 

Couture P, Otvos JD, Cupples LA, Wilson PW, Schaefer EJ, Ordovas JM. Association of the A-204C polymorphism in the cholesterol 7alpha-hydroxylase gene with variations in plasma low density lipoprotein cholesterol levels in the Framingham Offspring Study. J lipid Res 1999 40 1883-1889. 

Raloxifene (like tamoxifen) is associated with decreased breast cancer risk. Raloxifene is associated with decreases in total and low-density lipoprotein cholesterol, neutral effects on high-density lipoprotein cholesterol, but slight increases in triglycerides no beneficial cardiovascular effects have yet been demonstrated. 

The a-blockers have favorable effects (decreased low-density lipoprotein cholesterol and increased high-density lipoprotein cholesterol levels). However, because they do not reduce CV risk as effectively as thiazide diuretics, this benefit is not clinically applicable. 

Sevelamer Renagel 400, 800 Increase or decrease by 800 800-1,600 mg three times a day First-line agent lowers low-density lipoprotein cholesterol... 

Vogelvang TE, Mijatovic V, Kenemans P, Teerlink T, van der Mooren MJ (2004) HMR 3339, a novel selective estrogen receptor modulator, reduces total cholesterol, low-density lipoprotein cholesterol, and homocysteine in healthy postmenopausal women. Fertil Steril 82 1540-1549... 

A variety of clinical studies have demonstrated that elevated levels of total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B (apo B) are associated with... 

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