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Cholan-24-oic acid

HI - 5-beta-CHOLAN-24-OIC ACID, 3-alpha,7-beta-DIHYDROXY-RN - 126-13-2... [Pg.82]

Therapeutic Function Gallostone dissolving agent, Hepatoprotectant Chemical Name Cholan-24-oic acid, 3,7-dihydroxy-, (3a,5p,7p)-Common Name Ursodeoxycholic acid Ursodiol Ursotan Chemical Abstracts Registry No. 128-13-2 Raw Materials... [Pg.3383]

Roda A, Aldini R, Grigolo B et al. (1988) 23-Methyl-3a,7b-dihydroxy-5b-cholan-24-oic acid Dose-response study of biliary secretion in rat. Hepatol 8 1571-1576 Paglietti G, Sanna P, Carta A et al. (1994) Choleretic activity of 3-[ring substituted benzotriazol-l(2)yl]alkanoic and alkenoic adds. Farmaco 49 693-702 Peana A, Satta M, Luigi-Moretti MD, Orecchioni M (1994) A study on choleretic activity of Salvia desoleana essential oil. Planta Med 60 478 179... [Pg.161]

SYNS DEOXYCHOLATE SODIUM DEOXYCHOLIC ACID SODIUM SALT DIHYDROXY 3-12 CHOLANATE de Na (FRENCH) (3-a,5-3,12-a)-3,12-DIHYDROXY-CHOLAN-24-OIC ACID MONOSODIUM SALT 3-a,12-a-DIHYDROXY-5-3-CHOLAN-24-OIC ACID SODIUM SALT NA-DESOXYCHOLAT (GERMAN) NATRIUM-3-a,12-O-DIHYDROXYCHOLANAT (GERMAN) SODIUM DEOXYCHOLATE SODIUM DEOXYCHOLIC ACID... [Pg.1251]

One method for the preparation of 3a,7j -dihydroxy-5/I-cholan-24-oic acid (ursodeoxycholic acid, 4) is by transformation of lithocholic acid (3) by microorganisms belonging to Fungi imperfecti, or to Fusarium, typically Fusarium equiseti15S. [Pg.387]

The 7-carboxymethyloxime (483) of 3a,20a-dihydroxy-5j8-pregnan-7-one, derived in several steps from 3a,7a-dihydroxy-5j8-cholan-24-oic acid... [Pg.311]

Fig. 1. Chemical structures of SP-cholestane (A), Sp-cholan-24-oic acid (B), and bile acids found in human gallbladder bile (C-G). Fig. 1. Chemical structures of SP-cholestane (A), Sp-cholan-24-oic acid (B), and bile acids found in human gallbladder bile (C-G).
Bile acids contain hydroxyl groups, which are usually substituted at positions, C-3, C-7, or C-12 of the steroid nucleus. The three major bile acids found in man are 3a,7a,12a-trihydroxy-5P-cholan-24-oic acid 3a,7a-dihydroxy-5p-cholan-24-oic add and 3a,12a-dihydroxy-5p-cholan-24-oic acid. Because of the complexities of steroid nomenclature, bile acids are nearly always referred to by trivial names. 11108, the three major human bile acids are named cholic acid, chenodeoxycholic acid, and deoxycholic acid, respectively, and their chemical structures are shown in Fig. 1. Human bile does, however, contain small amounts of other bile acids, such as lithocholic acid (3a-hydroxy-5P-cholan-24-oic add) and ursodeoxycholic add (3a,7p-dihydroxy-5p-cholan-24-oic acid) (see Fig. 1). [Pg.171]

There is a wide variety in the types of bile acids found in different animal species. Some species have unique bile acids, such as a-muricholic acid (3a,6p,7a-trihydroxy-5p-cholan-24-oic add) and -muridiolic add (3a,6, 7 -trihydroxy- -cholan 24-oic acid) in rats and mice, and hyodeoxycholic acid (3a,6a-dihydroxy-Sp-cholan>24-oic acid) in pigs. Haslewood (H9) has studied the distribution of bile acids in the animal kingdom and has suggested that the C-24 adds, which are common to most advanced animal forms, can be regarded as the present endpoints in the evolution of the chemical structure of bile adds. [Pg.172]

The two bile acids, cholic acid and chenodeoxycholic acid, which are synthesized from cholesterol in the liver, are termed primary bile acids. Each day, around one-third to one-quarter of the primary bile acid pool is lost or converted to secondary bile acids by anaerobic bacteria in the intestine. This is achieved by 7a-dehydroxylation, a process which converts cholic acid to deoxycholic acid (3a,12a-dihydroxy-5p-cholan-24-oic acid) and chenodeoxycholic acid into lithocholic acid (3a-hydroxy-5 -cholan-24-oic acid). [Pg.185]

Ursodeoxycholic acid (3a,7p-dihydroxy-5p-cholan-24-oic acid) is present in human bile in small quantities and is of interest because of its therapeutic use as a gallstone-dissolving agent (D8). This bile acid is thought to be... [Pg.186]

Nearly all bile acids are choleretic agents that is, they increase bile flow when infused intravenously into various animal species. In all vertebrtae species examined, there is a close relationship between bile flow and the hepatic excretion rate of bile acids (B24). Acute interruption of the enterohepatic circulation of bile acids in man by diversion of bile flow causes the rate of bile secretion to decrease by about 50% (TIO). Thus, the excretion of bile acids from the liver is the major determinant of bile water and solute excretion, predominantly because of the osmotic activity of bile acids in bile. Some interesting studies in dogs have been performed with the bile salt taurodehydrocholate (taurine conjugate of 3,7,12-triketo-5fl-cholan-24-oic acid), which, for stereochemical reasons, cannot form micelles and should therefore have greater osmotic activity than other bile acids. At the same... [Pg.188]

Cholanic Acid, S0-Cholan-24-oic acid ursocho-lanic acid 176 -(I -methy].3-carboxypropy])etiocholane. C H Oj mol wt 360.56. C 79.94%, H 11.18%, O 8.87%, Steroidal acid probably formed by the dehydration and hydrogenation of certain bile acids commonly found in animals. Considered to be a chemical trademark certifying the prehistoric presence of some type of animal, see Seifert, Pure Appl. Chem. 34, 633 (1973). This status as a natural product of exclusive animal origins now questioned by its isolation from the embryo of the jequirity bean, Abrus precatorius, Leguminosae Mandava et al. Steroids 23, 357 (1974). [Pg.340]

Cholan-24-oic acid Cholanic acid C24H40O2 26312-66-6 360.674 nd (al), cry (HOAc) 163.6 s EtOH, chi, HOAc... [Pg.238]

Synonyms Cholalic acid Cholalin Colalin 3,7,12-Trihydroxycholanic acid 3a,7a,12a-Trihydroxy-5-p-cholan-24-oic acid... [Pg.927]

CAS 83-44-3 EINECS/ELINCS 201-478-5 Synonyms 5p-Cholan-3a,12p-diol Cholan-24-oic acid, 3,12-dihydroxy-, (3a,5p,12a])- Choleic acid Cholerebic Cholic acid, deoxy-Cholorebic Deoxycholatic acid Deoxycholic acid 5p-Deoxycholic acid 7-Deoxycholic acid 3a,12a-Dihydroxy-5p-cholanate 3,12-Dihydroxycholanic acid 3a,12a-Dihydroxycholanic acid 3a,12a-Dihydroxy-5P-cholanoic acid L7-p-(1-Methyl-3-carboxypropyl) etiocholane-3a,12o-diol Pyrochol Septochol Empirical C24H40O4... [Pg.1192]

CAS 475-31-0 EINECS/ELINCS 207-494-9 Synonyms Glycocholic acid, free acid 3a,7a,12a-Trihydroxy-5p-cholan-24-oic acid N-(carboxymethyl) amide 3a,7a,12a-Trihydroxy-5p-cholan-24-oylglycine N-(3a,7a,12a-Trihydroxy-5p-oxocholan-24-yl) glycine Definition Main component of human bile synthesized from cholic acid and glycine Empiricai C26H43NO6... [Pg.1933]

Sodium desoxycholate CAS 302-95-4 EINECS/ELINCS 206-132-7 Synonyms Deoxycholate sodium Deoxycholic acid sodium salt 7-Deoxycholic acid sodium salt (3-a,5-p, 12-a)-3,12-Dihydroxy-cholan-24-oic acid monosodium salt 3-a,12-a-Dihydroxy-5-p-cholan-24-oic acid sodium salt Sodium deoxycholate Sodium deoxycholic acid... [Pg.4010]

See other pages where Cholan-24-oic acid is mentioned: [Pg.358]    [Pg.82]    [Pg.1206]    [Pg.232]    [Pg.382]    [Pg.160]    [Pg.424]    [Pg.1633]    [Pg.1633]    [Pg.397]    [Pg.83]    [Pg.288]    [Pg.288]    [Pg.271]    [Pg.272]    [Pg.171]    [Pg.187]    [Pg.213]    [Pg.284]    [Pg.303]    [Pg.242]    [Pg.847]    [Pg.856]    [Pg.923]    [Pg.1345]    [Pg.4535]    [Pg.603]    [Pg.729]   
See also in sourсe #XX -- [ Pg.298 ]



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