Ursodeoxycholic acid Ursodiol

Ursodeoxycholic acid = ursodiol Actigall, Destolit, Ursofalk... [Pg.349]

Drugs like chenodeoxycholic acid (chenodiol) and ursodeoxycholic acid (ursodiol) can dissolve certain types of gallstones.28,45 These drugs decrease the cholesterol content of bile and may help dissolve gallstones that are supersaturated with cholesterol these drugs do not appear effective in the treatment of calcified gallstones.28... [Pg.397]

Therapeutic Function Gallostone dissolving agent, Hepatoprotectant Chemical Name Cholan-24-oic acid, 3,7-dihydroxy-, (3a,5p,7p)-Common Name Ursodeoxycholic acid Ursodiol Ursotan Chemical Abstracts Registry No. 128-13-2 Raw Materials... [Pg.3383]

Ursodeoxycholic acid (ursodiol), which is found in large quantities in bear bile, and which elicits an intense bitter taste, has long been used in traditional Chinese medicine not only as a stomachic but also as a universal drug for the alimentary system.1 8 Currently, the drug is generally derived by chemical synthesis rather than from animals. [Pg.650]

T riamcinolone-16,17-acetonide-21-phosphate Dehydrocholic acid Nabilone Dipyridamole Chenodeoxycholic acid Chenodiol Deoxycholic acid Ursodeoxycholic acid (ursodiol) Cholic acid... [Pg.735]

Ciclosporin + Bile acids or Ursodeoxycholic acid (Ursodiol)... [Pg.1025]

Ursodeoxycholic acid (Ursodiol) + Bile-acid binding resins... [Pg.1290]

In the bile cholesterol is kept soluble by fats, phospholipids like lecithin and by bile acids. The important bile acids in human bile are cholic acid, chen-odeoxycholic acid or chenodiol and ursodeoxycholic acid or ursodiol. Bile acids increase bile production. Dehydrocholic acid, a semisynthetic cholate is especially active in this respect. It stimulates the production of bile of low specific gravity and is therefore called a hydrocholeretic drug. Chenodiol and ursodiol but not cholic acid decrease the cholesterol content of bile by reducing cholesterol production and cholesterol secretion. Ursodiol also decreases cholesterol reabsorption. By these actions chenodiol and ursodiol are able to decrease the formation of cholesterolic gallstones and they can promote their dissolution. [Pg.385]

Destolit ursodiol, ursodeoxycholic acid Diatol tolbutamide... [Pg.647]

Jltracef ceftizoxime Urso ursodiol, ursodeoxycholic acid... [Pg.684]

Ursodiol (ursodeoxycholic acid) [128-13-2] M 392.5, m 203 , [a]g +6r (c 0.2, EtOH), pKsst 4.8. Recrystalhse ursodiol from wet Et20, EtOH or EtOH/MeOH. [Iwasaki Hoppe Seyler s Z Physiol Chem 244 181, 183 1936, Beilstein 10 111 1635.]... [Pg.661]

Ursodiol (ursodeoxycholic acid—UDCA), a bile acid with gallstone-stabilizing properties (8 to 10 mg/kg/day), is used for dissolution of radiolucent gallbladder stones and to increase the flow of bile in patients with bile duct prosthesis or stents. [Pg.717]

Ursodeoxycholic acid (UDCA ursodiol, actigall) (Figure 37-4) is a hydrophilic, dehydroxylated bile acid that is formed by epimerization of chenodeoxycholic acid (CDCA chenodiol) in the gut by intestinal bacteria it comprises l-3% of the total bile acid pool. When administered orally, litholytic bile acids such as chenodiol and ursodiol can alter relative concentrations of bile acids, decrease biliary lipid secretion, and reduce the cholesterol content of the bile so that it is less lith-ogenic. Ursodiol also may have cytoprotective effects on hepatocytes and effects on the immune system that account for some of its beneficial effects in cholestatic liver diseases. [Pg.652]

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