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Chitosan coated

In general these derivatives are safe, their chemical functions being the glycine moiety the same holds for AT,0-carboxymethyl chitosan, as demonstrated for instance by studies intended to assess the efficacy of W,0-carboxymethyl chitosan to limit adhesion formation in a rabbit abdominal surgery model. The inability of fibroblasts to adhere to N,0-carboxymethyl chitosan-coated surfaces suggests that it may act as a biophysical barrier [135]. [Pg.166]

Ribeiro, A. J., Neufeld, R. Arnaud, P. Chaumeil, J. C. (1999). Microencapsulation of lipophilic drugs in chitosan-coated alginate microspheres. International Journal of Pharmaceutics, Vol. 187,1, (September 1999), pp. (115-123), ISSN 0378-5173 Rubinstein, A. (1995). Approaches and opportunities in colon-specific drug-delivery. Critical Reviews in Therapeutic Drug Carrier Systems, Vol 12, 2-3,1995), pp. (101-149), ISSN 0743-4863... [Pg.83]

Another trend observed during the past decade was the coating of liposomes with mucoadhesive polymers. Liposomes are coated with chitosan, long-ehain polyvinyl alcohol, and polyacrylates bearing a cholesteryl group [90]. Chitosan-eoated liposomes showed superior adhesion properties to rat intestine in vitro than the other polymer-eoated liposomes. In vivo, chitosan-coated liposomes containing insulin substantially reduced blood glueose levels after oral administration in rats, whieh were sustained up to 12 hr after administration [90]. [Pg.187]

Takeuchi, H., Yamamoto, H., Niwa, T., Hino, T., and Kawashima, Y., Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomes, Pharm. Res., 13 896-901 (1996). [Pg.192]

Kang YO, Yoon IS et al (2010) Chitosan-coated poly(vinyl alcohol) nanofibers for wound dressings. J Biomed Mater Res Part B Appl Biomater 92B 568-576... [Pg.170]

FIGURE 3.6 Effect of squid meal liposome and chitosan samples on the body weight of myeloma sp2-bearing BALB/c mice. Twenty days after implantation of the cells, liposomes (l.Omg/mL), chitosan (5.0mg/mL), chitosan (5.0mg/mL)-liposomes (l.Omg/mL) mixture, and chitosan-coated (5.0mg/mL) liposomes (l.Omg/mL) were administered for 35days. The results are the means SD (n=12). Asterisks indicate significant difference as compared to control and liposome ( p<0.001). [Pg.42]

Filipovic-Grcic, J., Skalko-Basnet, N., and Jalsenjak, I. (2001). Mucoadhesive chitosan-coated liposomes Characteristics and stability. ]. Microencapsul. 18, 3-12. [Pg.45]

Peniche et al. (2004) successfully encapsulated up to 65 % of shark liver oil (rich in polyunsaturated fatty acids) in chitosan/alginate capsules in order to mask the oil s unpleasant taste. Here again it was found that the chitosan coating allowed a greater degree of control of capsule permeability. The capsules could be degraded by enzymes such as lipase or pancreatin. They were initially resistant to the acid environment of the stomach, although after 4 hours under intestinal conditions (pH = 7.4) the capsule walls were finally disrupted. [Pg.265]

Chitosan-Coated Liposomes Containing Peptide Drugs.61... [Pg.57]

Chitosan-Coated Nanoparticles Containing Peptide Drugs.62... [Pg.57]

When ketoprofen was loaded with chitosan-coated ethylcellulose microparticles and the plain ethylcellulose microparticles, similar findings were obtained. Although ketoprofen is well absorbed from the GI tract, chitosan appears to influence the absorption profile. Chitosan allowed the particles to make contact with the mucosal membrane and be retained at adhesive sites, which means that the drug remains in the small intestine longer. This facilitated the absorption of ketoprofen in chitosan-coated microparticles loaded with ketoprofen. Chitosan is considered to improve the absorption properties of plain microparticles [33]. [Pg.60]

FIGURE 3.2 Blood glucose concentration-time profiles in normal rats after oral administration of insulin-containing chitosan-coated liposomes, insulin-containing plain liposomes and insulin solution, and subcutaneous administration of insulin solution. Sol, solution Lip, liposomes Ch, chitosan s.c., subcutaneous. The results are expressed as the mean values. [Pg.61]

Takishima, J., H. Onishi, and Y. Machida. 2002. Prolonged intestinal absorption of cephradine with chitosan-coated ethylcellulose microparticles in rats. Biol Pharm Bull 25 1498. [Pg.67]

Wu, Z.H., et al. 2004. Hypoglycemic efficacy of chitosan-coated insulin liposomes after oral administration in mice. Acta Pharmacol Sin 25 966. [Pg.67]

De Campos, A.M., et al. 2003. The effect of a PEG versus a chitosan coating on the interaction of drug colloidal carriers with the ocular mucosa. Eur J Pharm Sci 20 73. [Pg.520]

AA-g-HDPE Chitosan coated HDPE Chitosan hydrogel coated HDPE Chitosan hydrogel coated HDPE+heparin... [Pg.281]

Bravo-Osuna, I., C. Vauthier, et al. (2008). Effect of chitosan and thiolated chitosan coating on the inhibition behaviour of PIBCA nanoparticles against intestinal metallopeptidases. J. Nanopart. Res DOI 10.1007/sl 1051-008-9364-5. [Pg.165]

These polymer-coated liposomes showed high potency in oral delivery of peptide drugs such as insulin and calcitonin, mainly because of the mucoadhe-sion of the chitosan-coated liposomes to the intestinal tract (Takeuchi et al. 1996, 2001,2003,2005a). Similar trials have been reported by Guo et al. (2003), who investigated the effect of chitosan concentration and lipid type on the characteristics of chitosan-coated liposomes and their interactions with leupro-lide. They found that a thicker adsorptive layer could be realized by using low... [Pg.174]


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