Coating agents chitosan

Chitosan-stabilized Au NPs can be selectively synthesized on surfaces like poly (dimethylsiloxane) (PDMS) films using HAuC14 as precursor. The computation of surface plasmon bands (SPBs) based on Mie theory and experimental results indicates that the particles are partially coated by chitosan. The proposed mechanism implies that chitosan acts as a reducing/stabilizing agent. Furthermore, PDMS films patterned with chitosan could induce localized synthesis of gold nanoparticles in regions capped with chitosan only [110]. 

In another way, chitosan was used as a coating agent for nanoparticles to improve their bioadhesive properties after oral and nasal administration. Indeed, chitosan is known to have bioadhesive properties as well as an interesting absorption enhancing capacity. 

Chitosan, a natural-based polymer obtained by alkaline deacetylation of chitin, is nontoxic, biocompatible, and biodegradable. These properties make chitosan a promising candidate for conventional and novel drug delivery systems. Because of the high affinity of chitosan for cell membranes, it has been used as a coating agent for liposome formulations [43-45]. 

Chitosan has been investigated as a coating agent for novel formulations such as liposomes and solid lipid nanoparticles. The coating of chitosan on nanostructured systems increases the drug bioavailability owing to its permeation enhancement properties [166,167]. 

Chitosan Extracted from shells of crustaceans such as shrimps and crabs Binder, Coating agent... 

Recently, Reddy et al. demonstrated that labeling of mesenchymal stem cells (MSCs) with superparamagnetic iron oxide nanoparticles (SPlONs) coated with chitosan did not alter the proliferation, surface marker expression or differentiation capacity of MSCs [92]. For comparison, Resovist, a commercially available MR contrast agent coated with carboxydextran, showed alteration to the chondrogenesis capacity of MSC. In addition, the chitosan-coated SPION-loaded MSCs did not show any toxic effects in viability studies over a 3-week period. Further, in vivo MR imaging of the chitosan-coated SPION-loaded MSCs injected into the brain of an ischemic brain rabbit model enabled the tracking of the stem cells for up to 2 weeks (Fig. 2). 

In addition to ABS, membranes using a polymer blend of chitosan and ABS with glutaraldehyde as a crosslinking agent have been used as coating materials for PES ultrafiltration membranes (90). 

Pectin has been used in film-coating formulations containing chitosan and hydroxypropylmethyl cellulose in the investigation of the biphasic drug-release properties of film-coated paracetamol tablets, both in vitro and in vivo It has been shown that chitosan acts as a crosslinking agent for concentrated pectin solutions. 

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