Chemokine expression patterns

Langenkamp A, Nagata K, Murphy K, Wu L, Lanzavecchia A, Sallusto F. Kinetics and expression patterns of chemokine receptors in human CD4+ T lymphocytes primed by myeloid or plasmacytoid dendritic cells. Eur J Immunol 2003 33 474 182. 

Kato M, Kitayama J, Kazama S, Nagawa H. Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma. Breast Cancer Res 2003 5 144-150. 

Wang J, Hunt JL, Gooding W, et al. Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype. Cancer Res 2004 64 1861-1866. 

A novel aspect of these experiments was the use of in vivo model systems, which express a cytokine profile consistent with either a Thl- or Th2-type response. We have utilized an experimental pulmonary granuloma model, which begins as a primary, Thl response, and naturally evolves into a response with Th2-type characteristics (52-54). This system allows for the assessment of the temporal expression pattern of chemokines and chemokine receptors and the mediator systems that are responsible for the expression of these ligands and receptors. 

Neutrophils are polymorph nuclear cells that are critical for defense against bacterial and fungal infections. Neutrophils are traditionally known to express only a very limited number of chemokine receptors and the recruitment of these phagocytes to the side of infection is mainly directed by the CXC chemokine subfamily, in particular CXCRl and CXCR2 [11-13]. However, the expression pattern of the chemokine receptors on the neutrophil is subjected to change. Hartl et al. (2008) described that neutrophils while infiltrating at the pulmonary and synovial site of inflammation... 

T cells are bone marro v-derived lymphocytes. There are six different types of Tcells identified in humans helper T cells (Th), cytotoxic T cells (Tc), memory T cells, regulatory T cells (Treg), natural killer T cells (NKT) and yb T cells. AD types have different roles in the adaptive immune systems and consequentiaUy distinct chemokine receptor expression patterns. 

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