Temporal expression

The HIV-1 coreceptors CXCR4 and CCR5 bind to ligand members of a family of molecules known as chemokines, or chemotactic cytokines. While the hallmark function of these small proteins is the direction of leukocyte trafficking, they can also participate in cellular events such as activation and costimulation (Bajetto et al. 2(X)la). Members of the chemokine family can be classified as either homeostatic or inflammatory based on their temporal expression (Charo and Ransohoff 2006 Kim 2005). Although traditionally the CNS had been thought to be protected from immune acti-... 

Szekanecz Z, Halloran MM, Volin MV, et al. Temporal expression of inflammatory cytokines and chemokines in rat adjuvant-induced arthritis. Arthritis Rheum 2000 43(6) 1266-1277. 

The cTs-regulatory elements described above and the factors that bind to these elements determine the spatial and temporal expression of the Ddc primary transcript. Like a number of other genes that are expressed in... 

The temporal expression pattern of the mouse tyrosinase gene during embryonic development was not known, and therefore we exploited the... 

FIG. 4. Temporal expression pattern of three Xenopus IAP family members. We have cloned three IAPs designated X-IAP1,2 and 3. This graph shows their developmental profile as assessed by RT-PCR. 

Kelly D. and King T.P. (1991). The influence of lactation products on the temporal expression of histo-blood group antigens in the intestines of suckling pigs lectin histochemical and immunohistochemical analysis . Histochem J, 23, 55-60. 

The relative importance of the two SPHK isoforms is unclear at present. They differ in their tissue distribution, with SPHKl mRNA expression being highest in lung, spleen and liver whereas liver and heart contain the highest levels of SPHK2. Additionally, their temporal expression differs in development with high levels of mouse SPHKl mRNA up to embryonic day 7 followed by a reduction in contrast to SPHK2, which is low to day 7 and increases thereafter to day 17 (Liu etal., 2000). 

Progression through the four phases of the cell cycle is tightly regulated by the temporal expression and destruction of CDK complexes. The het-... 

To compare the molecular mechanisms of circadian clocks in divergent species, we cloned and analysed circadian mRNA expression of human clock genes in serum shocked fibroblasts. We also developed novel antisera and examined the temporal expression of three PER proteins (hPERl, hPER2, and hPER3). The results showed robust circadian profiles of hPER protein abundance, phosphorylation and degradation. 

Pasquinelli AE, Reinhart BJ, Slaek F et al. Conservation of the sequenee and temporal expression of let-7 heteroehronie regulatory RNA. Nature 2000 408 86-89. 

Doering, C.B. Coursey, C. Spangler, W. Danner, D.J. Murine branched chain a-ketoacid dehydrogenase kinase cDNA cloning, tissue distribution, and temporal expression during embryonic development. Gene, 212, 213-219 (1998)... 

The cloning of the TT2 gene by T-DNA tagging was reported by Nesi et al. (2001). This gene encodes an R2R3 myb protein that shows similarity to the maize C1 protein. In order to test whether the TT2 protein functions as a transcriptional activator, Nesi et al. (2001) were able to show that this protein is localized in the nucleus, that the spatio-temporal expression... 

The depicted time-course experiment would be appropriate if identifying differentially expressed genes at any time-point compared to vehicle and temporal expression changes within treatment (including vehicle) compared to an adjacent time-point Population comparisons can be carried out between parent tumor samples (Tn) and metastases (Vn), as well as between all parent and metastases... 

Bhandari, N., Enongene, E. N., Riley, R. T., Meredith, F. I., and Sharma, R. P. (2002). Temporal expression of fumonisin B(l)-induced tumor necrosis factor-alpha and interferon gamma in mice. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 131(2), 113-122. 

Saitsu, H., Ishibashi, M., Nakano, H., and Shiota, K. (2003). Spatial and temporal expression of folate-binding protein 1 (Folbpl) is closely associated with anterior neural tube closure in mice. Dev. Dyn. 226(1), 112-117. 

Momoi T, Hanaoka K, and Momoi M (1990) Spatial and temporal expression of cellular retinoic acid binding protein (CRABP) along the anteroposterior axis in the central nervous system of mouse embryos. Biochemical and Biophysical Research Communications 169, 991-6. 

Messenger RNAs that are expressed only at a specific stage in development and encode proteins involved in specific developmental timing events. See Pasqninelli, A.E., Reinhart, B.J., Slack, R. et al.. Conservation of the seqnence and temporal expression of let-7 heterochronic regnlatory RNA, Nature 408, 86-89,2000 Moss, E.G., RNA interference it s a small RNA world, Curr. Biol. 11, R772-R775, 2001. 

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