Immune system adaptive

Humoral immunity depends on soluble, noncellular effector mechanisms of the immune system. These include defensins and complement components (proteins of the innate immune system) and antibodies (products of the adaptive immune system). They are capable of reacting with foreign substances (e.g., bacteria and viruses) to produce detoxification and elimination. 

Parallel to orchestrating acute inflammatory processes by providing an optimal milieu of cytokines, mediators, and adhesion molecules in order to recruit and activate effector cells to the site of infection, dendritic cells also setve as professional antigen-presenting cells for cells of the adaptive immune system ( antigen presentation ... 

NF-kB is also crucial for the proper functioning of the adaptive immune system not only by acting on the immune cells themselves but also by participating in the development and organization of the secondary lymphoid organs (lymph nodes, spleen, and Peyer s patches), in which both B and T lymphocytes undergo maturation and activation. NF-kB proteins have an important role in lymphocyte development and... 

IFNs are natural glycoproteins produced by the cells of most vertebrates in response to the challenge by foreign agents, such as infectious organisms (viruses, bacteria, fungi, and parasites), and by tumor cells. IFNs can be produced by cells of the innate and adaptive immune systems and by non-immune cells such as fibroblasts and epithelial cells. 

Specific defence mechanisms (adaptive immune system)... 

Flajnik, M.F., and Kasahara, M., Comparative genomics of the MHC Glimpses into the evolution of the adaptive immune system, Immunity, 15, 351, 2001. 

Rodent and human immunology has served to guide our understanding of the mammalian immune system, where the highly conserved innate immune system, and the more complex acquired or adaptive immune system, interact to protect the host from infection. 

The specific, or adaptive, immune system is characterized by memory, specificity, and the ability to distinguish self from nonself. The important cells of the adaptive immune system are the lymphocytes and antigen-presenting cells that are... 

A relatively sharp distinction must be drawn between what are termed the innate and the adaptive immunities (Ml). When an organism infects the body, the defense systems already in place may well be sufficient to prevent replication and spread of the infectious agent, thereby preventing the development of disease. These established mechanisms constitute the innate immune system. However, should innate immunity be insufficient to prevent the invasion by the infectious agent, the adaptive immune system then comes into action, although it takes time... 

On the one hand, are the soluble factors such as lysozyme and complement, together with the phagocytic cells that contribute to the innate system, and on the other hand are the lymphocyte-based mechanisms that produce antibody and the T lymphocytes, which represent the main elements of the adaptive immune system. Not only do these lymphocytes provide improved resistance by repeated contact with a given infectious agent, but the memory with which they become endowed shows very considerable specificity to that infection. 

Although closely related, monocytes/macrophages (MO) possess features that are distinct from DCs. Due to their limited expression of T-cell costimulatory molecules, MO are not able to prime T cells de novo, but rather stimulate effector/memory T cells by the secretion of cytokines, which support T-cell proliferation. As DCs, MO differentiate from myeloid precursors and form a heterogeneous population of antigen-presenting cells (APCs) that link the innate and adaptive immune systems. However, their ability to interact with T cells via MHC class II TCR interaction(s) as well as engagement of T-cell costimulatory receptors on their surface, makes close contact between MO and Tregs likely to occur in vivo. 

Immunity to Fungi Connecting the innate to the Adaptive immune System through DCs... 

Once the hapten has been designed and prepared, it is conjugated with a carrier protein to induce the best immunogenicity as possible to elicit an immune response in the animal (most commonly a mouse) in which it is inoculated. The antibodies produced by the defense mechanism of the adaptive immune system that specifically recognizes the hapten are then isolated, overproduced, and purified for testing their catalytic activity toward the targeted chemical reaction. 

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