Cellulose Hydroxypropyl methylcellulose

Excipients Cellulose, disodium hydrogen phosphate, hydroxypropyl cellulose, hydroxypropyl methylcellulose, lactose, mannitol, sodium lauryl sulfate, etc. 

Formuiation The formulation consists of excipients such as carnauba wax, crospovidone, hydroxylpropyl cellulose, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, and other inactive ingredients. 

Hydroxpropyl Cellulose Hydroxypropyl Methylcellulose Isobutylene-Isoprene Copolymer Locust Bean Gum... 

Cellulosics sodium carboxymethylcellulose, microcrystalline cellulose (including coprecipitates and blends of the two), hydroxyethylcellulose, hydroxy-propyl cellulose, hydroxypropyl methylcellulose, methylcellulose, starch, sodium starch glycolate, and powdered cellulose... 

Hydroxyethyl cellulose methyl cellulose hydroxypropyl methylcellulose... 

The FTIR characterization of dextrin, miCTocrystalline cellulose, hydroxypropyl methylcellulose, pullulan, alginate, carrageenan, chitosan, gnar gum, and gelatin biomaterials was successfully performed. Also specific markers for each tested biomaterials were identified. 

We express our gratitude to BRACE GmbH for the donation of some analyzed biopolymers (alginate, chitosan, microcrystalline cellulose, hydroxypropyl methylcellulose, dextrin, and pullulan) used in this entry. 

The major commercial viscous vehicles are hydroxypropyl methylcellulose (Isopto ) and polyvinyl alcohol (Liquifilm ). Isopto products most often use 0.5% of the cellulosic and range from 10 to 30 cP in viscosity. Liquifilm products have viscosities of about 4-6 cP and use 1.4% polymer. 

Jansen PJ, Kemp CA, Maple SR, Baertschi SW. Characterization of Impurities found by interaction of Duloxetine HC1 with enteric polymers hydroxy-propyl methyl cellulose acetate succinate and hydroxypropyl methylcellulose phthalaie. J Pharm Sci 1998 87(1) 81—85. 

As previously discussed, food effects are an important parameter for enteric-coated systems, especially for drugs, that are sensitive to food. Pancreatic enzyme-containing products fail when they come in contact too early with lipids, proteins, and carbohydrates present in food. The clinical efficacy of pancreatic enzymes formulated as enteric-coated tablets was investigated in man and dog [44], The enteric materials examined were hydroxypropyl methylcellulose phthal-ate (HPMCP), cellulose acetate phthalate (CAP), and the methacrylic acid copolymer USP/NF Type C. In vivo behavior monitored by x-ray scintigraphy showed clear differences between the three coating formulations. HPMCP-coated products adhered to the gastric mucosa, whereas CAP and methacrylate copolymer... 

The mechanism of separation with linear polymers is as follows. At a certain polymer concentration known as the entanglement threshold, the individual polymer strands begin to interact with each other, leading to a meshlike structure within the capillary. This allows DNA separation to take place. Many of the common polymers are cellulose derivatives, such as hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, and methylcellulose. Other applicable polymers include linear polyacrylamide, polyethylene oxide, agarose, polyvinyl pyrrolidone, and poly-N. Ar-dimethylacrylamide. High-resolution separation up to 12,000 bp has been reported using entangled polymer solutions. 

Hydroxypropyl methylcellulose acetate succinate Hydoxypropyl methylcellulose phthalate Methyl cellulose... 

Water-soluble hydroxypropylmethyl cellulose and water-insoluble cellulose acetate are further treated with phthalic anhydride or succinic anhydride to yield hydroxypropyl methylcellulose phthalate, cellulose acetate phthalate, and hydroxypropyl-methylcellulose acetate succinate. These polymers are used as enteric materials and are water soluble or insoluble above or below a specific pH, respectively. 

A popular approach to improve ocular drag bioavailability is to incorporate soluble polymers into an aqueous solution to extend the drug residence time in the cul-de-sac. It is reasoned that the solution viscosity would be increased and hence solution drainage would be reduced. The more commonly used viscolyzing agents include PVA and derivatives of cellulose. Cellulosic polymers, such as methylcellulose, hydroxyethylcellulose (HEC), hydroxypropyl-methylcellulose (HPMC) and hydroxypropylcellulose (HPC), are widely used as viscolyzers showing Newtonian properties. They have common properties ... 

Oralsolv (CIMA Labs Inc.) Remeron Soltab Mirtazepine (15, 30, or 45mg), aspartame, citric acid, crospovidone, hydroxypropyl methylcellulose, magnesium stearate, mannitol, microcrystalline cellulose, polymethacrylate, povidone, sodium bicarbonate, starch, sucrose, orange flavor Compression... 

Cellulose derivatives Chitosans Gelatin Sodium carboxymethylcellulose (NaCMC) Methylcellulose (MC) Hydroxypropyl methylcellulose (HPMC) Hydroxypropyl cellulose (HPC) Hydroxyethyl cellulose (HEC)... 

Acyclovir is a potent inhibitory of viruses of the herpes group, particularly herpes simplex virus (HSV I and II) and herpes zoster varicella virus. Unfortunately, acyclovir has a short half-life (2-3 h), and the oral dosage form must be taken five times daily, which is very inconvenient for patients [75,76], Consequently, the aim of this study was to develop a controlled-release formulation of acyclovir that could be taken twice daily. The materials used to prepare the tablets were acyclovir (Kern Pharma, Tarrasa, Barcelona) and hydroxypropyl methylcellulose (Methocel K4M) (Colorcon) a hydrophilic cellulose derivative as the matrix-forming material. 

Like PVA, the viscosity enhancer hydroxypropyl methyl-cellulose is available in a variety of molecular weights and in formulations with different group substitutions. It has been shown to prolong tear film wetting time and to increase the ability of fluorescein and dexamethasone to penetrate the cornea. Hydroxypropyl methylcellulose 0.5% has been shown to exhibit twice the ocular retention time of 1.4% PVA. 

Substituted Cellulose Ethers. Since their introduction for ophthalmic use, MC and other substituted cellulose ethers such as hydroxyethylcellulose, hydroxypropylcel-lulose, hydroxypropyl methylcellulose (HPMC), and carboxymethylcellulose (CMC) have been used in artificial tear formulations.These colloids dissolve in water to produce colorless solutions of varying viscosity. They have the proper optical clarity, a refractive index similar to the cornea, and are nearly inert chemically. Their relative lack of toxicity, their viscous properties, and their beneficial effects on tear film stability have made cellulose ethers useful components of artificial tear preparations. Historically, the most frequently used representative of this group was MC. 

A review of vaginal bioadhesive formulations indicates that bioadhesive tablets have been used for localized treatment of diseases in the vaginal tissue.F ° l For example. Bleomycin, an antitumor agent, was incorporated into a flat-faced disk fabricated from a combination of hydroxypropyl cellulose and poly-(acrylic acid) (Carbopol 934). ° The tablet was designed to release Bleomycin at a slow rate to minimize irritation to healthy mucosa. Another vaginal tablet is formulated from the combination of poly(acrylic acid) with hydroxypropyl methylcellulose and ethylcellu-lose. Other polymer combinations evaluated for potential bioadhesive vaginal delivery include poly(acrylic acid) and sodium carboxymethyl cellulose with Avicel PH102 (methylcellulose) as the diluent. Insulin has been formulated in a cross-linked poly(acrylic acid) gel... 

Rowe, R.C. The prediction of compatibihty/incompatibility in blends of ethyl cellulose with hydroxypropyl methylcellulose or hydroxypropyl cellulose using 2-dimen-sional solubility parameter maps. J. Pharm. Pharmacol. 1986, 38, 214-215. 

Hjartstam, J. Borg, K. Lindstedt, B. The effect of tensile stress on permeability of free films of ethyl cellulose containing hydroxypropyl methylcellulose. Int. J. Pharm. 1990, 61, 101-107. 

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