Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Extra cellular matrix

Abstract Raman spectroscopy can potentially offer a non-invasive, information rich biochemical snap-shot of living human cells, tissues or material-cell tissue constructs rapidly (seconds-minutes), without the need of labels or contrast enhancers. This chapter details the exciting potential and challenges associated with the use of this analytical technique in tissue engineering (TE). The use of Raman spectroscopy in three intricately linked areas of TE will be considered (1) the characterisation of the various scaffolds and smart materials, (2) the biochemical analysis of cellular behaviour important in TE (e.g. differentiation) and (3) the use of Raman spectroscopy for the analysis of tissue/extra-cellular matrix (ECM) formation in vitro or possibly in vivo. [Pg.419]

The MMPs are a family of zinc-dependent neutral endopep-tidases that share structural domains but differ in substrate specificity, cellular sources, and inductivity (Table I). All the MMPs are important for remodeling of the extra cellular matrix and share the following functional features (/) they degrade extracellular matrix components, including fibronectin, collagen, elastin, proteoglycans, and laminin, (//) they are secreted in a latent proform and require activation for proteolytic activity, (///) they contain zinc at their active site and need calcium for stability, (/V) they function at neutral pH, and (v) they are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). [Pg.325]

While the effect on tests requiring the interaction of the tumour cells with extra cellular matrix components suggest that the interaction of RAPTA compounds with cell surface molecules may be responsible for part of their activity, the compounds also accumulate within cancer cells and interact to a significant extent with proteins in the cytoplasm. Adduct formation of RAPTA compounds with proteins has been studied using mass spectrometric methods [10, 25, 26]. In general, rapid and irreversible binding has been observed. In a recent study the reactivity of cisplatin and RAPTA-C with a mixture of proteins was probed without using any... [Pg.61]

Plant and animal tissue has a complex microstructure (e.g., Khaled and Vafai, 2003), consisting of cells, extra-cellular matrix (ECM), and porosity. Tissue and other biological systems are usually structured over several length-scales (Chu and Lee, 2004). Convective transport in a tissue is controlled by the vascular... [Pg.195]

This molecule is hypothesized to be involved in degradation of the endothelial extra cellular matrix in vasculitic neuropathy. [Pg.293]

Inflammation. Chemically related to heparin is the GAG, hyaluronic acid. It is a natural component of the extra-cellular matrix found in connective tissues. Clinical invers-tigations have demonstrated the safety and ef-... [Pg.210]

The aim of the second project, 3G-SCAFF (Third Generation Scaffolds for Tissue Engineering Regenerative Medicine) , is to develop an extra-cellular matrix to be used as biomaterial. This matrix is a complex composition of essential materials oe cells live and grow. The cells are used as a micro foctory for the productirm and composition of a molecular structure - the extra cellular matrix - that cannot be produced with synthetic instruments. [Pg.354]

E. and F. Higher magnification of C. and D., respectively. This shows the richer, more developed urotlielial cell and extra cellular matrix coverage resulting from the changing tensional forces in support of the principle of tensegrity. Reproduced with permission from Urry and Pattanaik, 1997. [Pg.387]

Suzuki, Y, Kusakabe, M., Kaibara, M., Iwaki, M., Sasabe, H., and Nishisaka, T., Cell adhesion control by ion implantation into extra-cellular matrix, Nucl. Instrum. Methods Phys. Res., B9I, 588-592 (1994). [Pg.419]

Cell colonize pores and creates own extra cellular matrix... [Pg.613]

TheraSkin Soluble systems (US) Cryopreserved human skin allograft, composed of living cells, fibroblasts, and keratinocytes, and a fully developed extra cellular matrix Skin substitute Marketed... [Pg.382]

Beer, M.V., Rech, C., Gasteier, P., Sauerzapfe, B., Salber, )., Ewald, A., Moller, M., Elling, L, and Groll, J. (2013) The next step in biomimetic material design poly-LacNAc-mediated reversible exposure of extra cellular matrix components. Adv. Healthcare Mater., 2, 306-311. [Pg.154]

See other pages where Extra cellular matrix is mentioned: [Pg.184]    [Pg.249]    [Pg.398]    [Pg.325]    [Pg.61]    [Pg.216]    [Pg.157]    [Pg.283]    [Pg.283]    [Pg.111]    [Pg.218]    [Pg.274]    [Pg.267]    [Pg.203]    [Pg.76]    [Pg.207]    [Pg.9]    [Pg.46]    [Pg.217]    [Pg.364]    [Pg.33]    [Pg.344]    [Pg.844]    [Pg.12]    [Pg.143]    [Pg.129]    [Pg.437]    [Pg.22]    [Pg.154]    [Pg.168]    [Pg.11]    [Pg.65]    [Pg.249]    [Pg.349]    [Pg.451]    [Pg.55]   
See also in sourсe #XX -- [ Pg.168 ]



SEARCH



Extra

Matrices, cellular

© 2024 chempedia.info