Cardiovascular studies

Electroencephalographic and cardiovascular studies of (3) have been performed [41]. There is also a detailed report on the action of (3) on the central nervous system [42] and on the effect of (3) on -endorphin release in rats [43], It has been shown that (3) does not produce physical dependence upon chronic administration to animals [44],... 

ECG (QT measurements) in a cardiovascular study which would be covered in the core battery... 

Lamarche, B., Tchemof, A., Moorjani, S., Cantin, B., Dagenais, G. R., Lupien, P. J., and Despres, J. P. (1997). Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study. Circulation 95, 69-75. 

Surrogate endpoints are particularly useful in cases where the clinical endpoints occur after long periods. This is particularly relevant to cardiovascular disease. High blood pressure is a well-established cardiovascular surrogate endpoint it is well established that chronic high blood pressure is causative of cardiovascular and cerebrovascular events. Kannel and Sorlie (1975) commented on data from the Framingham Heart Study, a major prospective cardiovascular study of over 5,000 individuals ... 

Carcinogenicity used the 12-month repeat dose study instead of a standard 2-year bioassay Other cardiovascular study in dogs drug interaction study with NPH insulin immunogenicity in rabbits In vitro immunology, and Athymic nude mice proof of concept studies... 

Hall WD. 1993. Screening and recruitment of elderly participants into large-scale cardiovascular studies . In Inclusion of Elderly Individuals into Clinical Trials, Wenger NK (ed.). Marian Mennel Dow Kansas 67-71. 

UrquhartJ. 1991. Patient compliance as an explanatory variable in four selected cardiovascular studies . In Compliance in Medical Practice and Clinical Trials, Cramer JA, Spilker B (eds). New York Raven Press 301-322. 

The Heart Protection and PROSPER results do draw into question preventative effects of statins on dementia. On the other hand, the CHS study raises the possibility that statins may beneficially impact the rate of cognitive changes. Cardiovascular-based studies only indirectly measure the impact on dementia since most cardiovascular studies exclude patients with dementia and cardiovascular trials employ cognitive tests that are relatively insensitive for populations that are not aheady demented. Eurthermore, assessment of cognitive decline in patients aheady suffering from cognitive deficits remains a critical component to the effective treatment of AD. 

Antidepressants and 5-HT - Because of the possibility of reduced cardlo-toxicity, interest was maintained in 1978 in compounds which are selective inhibitors of 5-HT uptake, many of which were reported in Volume 13 of this series21 and elsewhere. Open clinical studies of zimelldlne ( ) showed good antidepressant effects after doses of 150 mg daily. 7 The claimed rapid onset of action of was not confirmed in the first double-blind trial in hospitalized depressives given single bedtime doses of or amitriptyline for A weeks. 8 No difference in efficacy emerged, but side-effects were fewer with A cardiovascular study showed and mianserin... 

CABG, coronary artery bypass MI, myocardial infarction CAD, coronary artery disease NTG, nitroglycerin CCS, Canadian cardiovascular study ECG, electrocardiogram. 

Cardiovascular Studies Unit University of Pennsylvania Philadelphia, Pennsylvania... 

Reul, H. and Talukdar, N. 1979. Heart valve mechanics. In Quantitative Cardiovascular Studies Clinical and Research Applications of Engineering Principles. Hwang, N.H.C., Gross, D.R., and Patel, D.J., Eds. University Park Press, Baltimore, MD, pp. 527-564. 

H. Reul and N. Talukder, Heart valve mechanics, in "Quantitative cardiovascular studies - Clinical and research applications of engineering principles," N. H. C. Hwang, D. R. Gross and D. J. Patel, ed., University Park Press, Baltimore (1979). 

LATITUDE-TIMl 60 Press Release (2015) GSK provides update on LATITUDE-TIMI 60 (losmapimod cardiovascular study). 27th October 2015. Available at https //www.gsk.com/en-gb/ media/press-releases/2015/gsk-provides-update-on-latitude-timi-60-losmapimod-cardiovascular-study Accessed 22 Dec 2015... 

Thus, application of in silico methods, with noted hmitations, may have use in studies preceding frontloading SP cardiovascular studies provided that the... 

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