Cognitive deficit

Vinpocetine (2), another dmg initially categorized as a cerebral vasodilator, is a member of the vinca alkaloid family of agents (7). However, interest in this compound as a potential dmg for learning and memory deficits comes from its abiUty to act as a neuronal protectant. This compound was evaluated in 15 patients with AD over a one-year period and was ineffective in improving cognitive deficits or slowing the rate of decline (8). However, in studies of patients with chronic vascular senile cerebral dysfunction (9) and organic psycho syndrome (10), vinpocetine showed beneficial results. 

Cognitive deficits Poor concentration Feeling of hopelessness ... 

Qrandjean P, Weihe P, White RF, Debes F, Araki S, Yokoyama K, Murata K, Sorensen N, Dahl R, Jorgensen PJ. 1997. Cognitive deficit in 7-year-old children with prenatal exposure to methyhnercury. Neurotoxicol Teratol 19 417 28. 

A. The development of multiple cognitive deficits manifested by both... 

B. The cognitive deficits in criteria A1 and A2 each cause significant impairment in social or occupational functioning and represent a significant decline from a previous level of functioning. 

Howard H Brigham Women s Hospital, Boston, MA Examine the relationship between lead exposure and hypertension, renal dysfunction and cognitive deficits in middle-aged adults National Center for Research Resources... 

The ACGIH also notes that if a child s blood lead level remains elevated, the child may be at increased risk of cognitive deficits (ACGIH 1998). The ACGIH has adopted BEIs for various substances. The BEI for a substance is an industrial hygiene reference value to be used in evaluating potential health hazards. 

Lanphear BP, Dietrich K, Auinger P, Cox C (2000) Cognitive deficits associated with blood lead concentrationsblO mu g/dL in US children and adolescents. Public Health Rep 115 521-529... 

MDMA (Ecstasy) No clinical uses, although it has been used for psychotherapy recreational use widespread acute hyperthermic problems midweek depression during neurochemical depletion long-term problems include neurotoxicity, memory/cognitive deficits and a range of psychiatric problems. 

Nimodipine A voltage-operated Ca2+ channel blocker with potential benefits in treating cognitive deficits and managing opiate and alcohol detoxification. 

Fox H, Parrott AC and Turner JJD (2001). Ecstasy/MDMA related cognitive deficits A function of dosage rather than awareness of problems. Journal of Psychopharmacology, 15, 273-281. 

The availability of transgenic mice that faithfully recapitulate NP generation but fail to progress to neurofibrillary tangle formation, show little or no neuronal loss, and demonstrate modest at best cognitive deficits... 

Anticholinergic side effects include dry mouth, blurred vision, constipation, and urinary retention. More serious reactions include forgetfulness, sedation, depression, and anxiety. Patients with preexisting cognitive deficits and the elderly are at greater risk for central anticholinergic side effects. 

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