Cardiovascular Safety Studies in Conscious Dogs and Other Species

Cardiovascular Safety Studies in Conscious Dogs and Other Species 

The transducers of the telemetry implant are calibrated prior to implantation and the unit is sterilized using a low pressure ethylene oxide process. 

Dogs are anaesthetized with a combination of Rompun (xylazine hydrochloride, 1 ml/10 kg, i.v.) and Ketavet (ketamine hydrochloride, 0.7 ml/10 kg, i.v.) after premedication with Temgesic (Buprenorphin, 0.2mg/kg i.m.) and ventilated with 66% N2O and 33 % O2 and 1 % Isofluorane. All procedures are performed under aseptic conditions using sterilized equipment. 

The left ventricular pressure transducer is then implanted. The pericardium is opened so that the apex of the heart is exposed. The heart is gently held in one hand and two stitches in the ventricular wall for fixation are made. A purse-string suture is made around the apex. A sharp spike is then placed into the apex of the left ventricle and the transducer is placed into the ventricle and sutured firmly in place. 

The lung is then inflated and the intercostal muscles are sutured closed. The ECG lead is then fixed close to the sternum in the sixth intercostal space. The muscle 

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