Insulin immunogenicity

Continuous intraperitoneal infusion of insulin causes increased insulin immunogenicity, but it is not known if this is accompanied by an increased frequency of autoimmune diseases. Antibodies against insulin, thyroglobulin, thyroperoxidase, gastric parietal cells, smooth muscle,... 

Carcinogenicity used the 12-month repeat dose study instead of a standard 2-year bioassay Other cardiovascular study in dogs drug interaction study with NPH insulin immunogenicity in rabbits In vitro immunology, and Athymic nude mice proof of concept studies... 

Human insulin, which is now less expensive than monospecies pork insulin and is also less immunogenic, has supplanted purified pork insulins. 

Human insulins appear to be as effective as—and considerably less immunogenic in diabetic patients than—beef-pork insulin mixtures and slightly less immunogenic than pork insulin. 

Fineberg SE, Galloway JA, Fineberg NS, Rathbun MJ, Hufferd S Immunogenicity of recombinant human insulin. Diabetolo-gia (1983) 25 465 69. 

Other mitogenicity in CHO-K1 and human BIO osteosarcoma cells, human hepatoma cells and MCF-7 cells to include drug binding study to IGF-1 and insulin receptors local tolerance in pigs immunogenicity studies in rabbits... 

Baker, R. S., Schmidtke, J. R., Ross, J. W., and Smith, W. C. (1981). Preliminary studies on the immunogenicity and amount of Escherichia coli polypeptides in biosynthetic human insulin produced by recombinant DNA technology. Lancet 2(8256), pp. 1139-1142. 

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