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Merkel cells

Merkel cells are not distributed homogenously throughout the body (they are abundant on the lips, digits, and mouth), and they remain the most mysterious cells of the skin. Their origin has even been debated origin from the neural crest or from epidermal precursors. Merkel cells possess secretory granules contaiifing various biochemical [Pg.24]

They are often grouped together in small units called Merkel disks which, situated at the base of [Pg.25]

Langerhans cells are immunocompetent and recognize exogenous antigens which arrive in the epidermis. They have a notched nucleus and some specific granules, the Birbeck bodies Fig. 2.6. [Pg.25]

The granules in the form of zippers or rackets are absolutely specific to Langerhans cells. [Pg.25]

Langerhans cell, high magnification showing the birbeck granule [Pg.26]

Sometimes the distribution of keratin staining in a particular cell may aid in determining its origin. As mentioned before, Merkel cell and other neuroendocrine carcinomas characteristically have a perinuclear ball-like reactivity. [Pg.424]

Miettinen, M. (1995) Immunohistochemical marker for gastrointestinal, urothelial, and Merkel cell carcinoma. Mod. Pathol. 8, 384-388. [Pg.435]

Greenlee JE, Steffens JD, Clawson SA, Hill K, Dalmau J. Anti-Hu antibodies in Merkel cell carcinoma. Atm Neurol 2002 52(1) 111115. [Pg.174]

A second cancer is possible when treating a tnmor by mutagenicity or immunosnppression. There may be a link between the therapy given and the development of Merkel cell carcinoma (21). [Pg.3070]

A 54-year-old man with stage I folUcnlar Ijmphocytic lymphoma with cervical lymph nodes nnderwent splenectomy followed by chemotherapy with chlorambncil and had a partial response. Five months later, when he developed generalized lymphadenopathy and bone marrow involvement, he received fludarabine, cyclophosphamide, and ritnximab, with complete remission. Ten months later he developed a Merkel cell carcinoma involving the liver and lymph nodes. The disseminated tumor was chemoresistant and he died. His lymphoma remained in complete clinical remission throughout this time. [Pg.3070]

Cohen Y, Amir G, Polliack A. Development and rapid dissemination of Merkel-cell carcinomatosis following therapy with fludarabine and rituximab for relapsing follicular lymphoma. Eur J Haematol 2002 68(2) 117-19. [Pg.3071]

Meissner s corpuscle Melanocyte Merkel cells Langerhans ce Stratum corneum Stratum lucidum ... [Pg.2417]

Simple epithelial cells of gastrointestinal tract Merkel cells of skin CK20 46 kD... [Pg.84]

Small cell neuroendocrine (Merkel cell) carcinoma... [Pg.103]

Soslow RA, Wallace M, Goris J, et al. MIC2 gene expression in cutaneous neuroendocrine carcinoma (Merkel cell carcinoma). Appl Immunohistochem. 1996 4 235-240. [Pg.130]

Buresh CJ, Oliai BR, Miller RT. Reactivity with TdT in Merkel cell carcinoma A potential diagnostic pitfall. Am J Clin Pathol. 2008 129 894-898. [Pg.133]

Kontochristopoulos GJ, Stavroporrlos PG, Krasagakis K, et al. Differentiation between Merkel cell carcinoma and malignant melanoma an immrmohistochemical study. Dermatology. 2000 201 123-126. [Pg.203]

Battifora H, Silva EG. The use of antikeratin antibodies in the immunohistochemical distinction between neutoendoctine (Merkel cell) carcinoma of the skin, lymphoma, and oat cell cat-cinoma. Cancer. 1986 58 1040-1046. [Pg.204]

Simple epithelia, most glandular and squamous epithelia (basal) Simple epithelia of intestines and stomach, Merkel cells CK19 40... [Pg.215]

CK20 (+) colorectal, pancreas, mucinous ovarian, Merkel cell, and urothelial carcinomas. [Pg.217]

Chan JK, Suster S, Wenig BM, et al. Cytokeratin 20 immuno-reactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites. Am J Surg Pathol. 1997 21 226-234. [Pg.247]

Moll I, Kuhn C, Moll R. Cytokeratin 20 is a general marker of cutaneous Merkel cells while certain neuronal proteins are absent. Invest Dermatol. 1995 104 910-915. [Pg.247]

Lundquist K, Kohler S, Rouse RV. Intraepidermal cytokeratin 7 expression is not restricted to Paget cells but is also seen in Toker cells and Merkel cells. Am J Surg Pathol. 1999 23 212-219. [Pg.255]

Cheuk W, Kwan MY, Suster S, et al. Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas. Arch Pathol Lab Med. 2001 125(2) 228-231. [Pg.287]

See other pages where Merkel cells is mentioned: [Pg.421]    [Pg.424]    [Pg.219]    [Pg.338]    [Pg.53]    [Pg.852]    [Pg.855]    [Pg.1069]    [Pg.391]    [Pg.411]    [Pg.381]    [Pg.2417]    [Pg.46]    [Pg.12]    [Pg.161]    [Pg.214]    [Pg.214]    [Pg.216]    [Pg.217]    [Pg.218]    [Pg.226]    [Pg.227]    [Pg.227]    [Pg.294]   
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See also in sourсe #XX -- [ Pg.1127 ]



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