Diagnostic value

Studies on covalent hydration of N-heterocycles (67AG(E)919,76AHC(20)117) have revealed the diagnostic value of alkyl substituents in structural assignments due to their steric hindrance effects in addition reactions. C-Methyl substituents are therefore also considered as molecular probes to solve fine-structural problems in the pteridine field. The derivatives... 

In his valence bond theory (VB), L. Pauling extended the idea of electron-pair donation by considering the orbitals of the metal which would be needed to accommodate them, and the stereochemical consequences of their hybridization (1931-3). He was thereby able to account for much that was known in the 1930s about the stereochemistry and kinetic behaviour of complexes, and demonstrated the diagnostic value of measuring their magnetic properties. Unfortunately the theory offers no satisfactory explanation of spectroscopic properties and so was... 

Glycosydation AChE and BChE carry 3 and 9, respectively, N-glycosylation consensus sequences attaching carbohydrate residues to the core protein via asparagines. Different molecular forms of the enzymes in various tissues, show different number and composition of carbohydrate residues. N-glycosylation at all sites was shown to be important for effective biosynthesis, secretion and clearance of ChEs from the circulation. Altered patterns of AChE glycosylation have been observed in the brain and cerebrospinal fluid of Alzheimer s disease (AD) patients, with potential diagnostic value. 

Kresge and Chiang15 showed that the dependence of rate coefficient upon the Hammett acidity function was not a safe criterion of mechanism and also explained how different dependencies of rate upon acidity function for different compounds could arise. Rate coefficients for detritiation of [3H]-2,4,6-tri-methoxybenzene followed the acidity function h0 in perchloric acid up to 3 M, i.e. k = 0.484 (Ao)1 07. so that a plot of log k versus —H0 would have a slope of 1.07, which implies the A-l mechanism. (New acidity function values479 would make this slope 1.14.) However, the diagnostic value of such a correlation was... 

Schwartz LB Diagnostic value of tryptase in anaphylaxis and mastocytosis 2. Immunol Allergy Clin North Am 2006 26 451-463. 

This reaction helps transfer certain amino acids across the plasma membrane, the amino acid being subse-quendy hydrolyzed from its complex with GSH and the GSH being resynthesized from cysteinylglycine. The enzyme catalyzing the above reaction is 7-glu-tamyltransferase (GGT). It is present in the plasma membrane of renal mbular cells and bile ducmle cells, and in the endoplasmic reticulum of hepatocytes. The enzyme has diagnostic value because it is released into the blood from hepatic cells in various hepatobihary diseases. 

Table 5.5 shows the main characteristics of UV spectrophotometry as applied to polymer/additive analysis. Growing interest in automatic sample processing looks upon spectrophotometry as a convenient detection technique due to the relatively low cost of the equipment and easy and cheap maintenance. The main advantage of UV/VIS spectroscopy is its extreme sensitivity, which permits typical absorption detection limits in solution of 10-5 M (conventional transmission) to 10 7 M (photoacoustic). The use of low concentrations of substrates gives relatively ideal solutions [20]. As UV/VIS spectra of analytes in solution show little fine structure, the technique is of relatively low diagnostic value on the other hand, it is one of the most widely used for quantitative analysis. Absorption of UV/VIS light is quantitatively highly accurate. The simple linear relationship between... 

Routine identification and analytical characterization of all types of NHPs was preferably carried out by multinuclear NMR spectroscopy. Of particularly high diagnostic value are 31P NMR spectra where rather specific chemical shift ranges for heterocycles with different types of P-substituents can be observed. The largest chemical shifts occur for anionic and neutral 1,3,2-diazaphospholes (220-300 ppm) and 1,3,2-diazaphospholenium cations (210-200 ppm). Chemical shifts of P-halogen-l,3,2-diazaphospholenes vary over an overall range of 200-110 ppm and decrease in the order I (205-190 ppm)>Br (194-185 ppm two compounds... 

Scharfe C et al. MITOP, the mitochondrial proteome database 2000 update. Nucleic Acids Res 2000 28 155-158. Molloy MP et al. Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map new proteins of potential diagnostic value. Electrophoresis 1997 18 2811-2815. 

Shakhova, N.M., Gelikonov, V.M., Kamensky, V.A. and Kuranov, R.V. (2002). Clinical aspects of the endoscopic optical coherence tomography and the ways for improving its diagnostic value. Laser Physics 12 617-626. 

Laboratory findings include leukocytosis with predominance of mature and immature granulocytes in 50% to 75% of patients. Because L. pneumophila stains poorly with commonly used stains, routine microscopic examination of sputum is of little diagnostic value. Fluorescent antibody testing can be performed to diagnose Legionnaires disease. 

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