Promotion, carcinogenesis

Kitchin KT, Brown JL, Setzer RW. 1994. Dose-response relationship in multistage carcinogenesis promoters. Environ. Health Perspect. 102 255-64... 

Kitchin, K. T., Brown, J. L., and Setzer, R. W. (1994). Dose-response relationship in multistage carcinogenesis Promoters. Environ Health Perspect 102(Suppl 1), 255—264. 

Fukushima, S., Kurata, Y., Hasegawa, R., Asamoto, M., Shibata, M. A., and Tamano, S., 1991, L-Ascorbate acid amplification of bladder carcinogenesis promotion by K2CO3, Cancer Res. 51 2548-2551. 

S. Narasimhan, H. Schachter, S. Rajalakshmi, Expression of N-acetylglucosaminyltransferase III in hepatic nodules during rat liver carcinogenesis promoted by orotic acid, J Biol Chem, 1988, 263, 1273-1281. 

A toxic component of braken fern, perhaps either quercetin (105) or ptaquiloside, a glucoside (106), has a mixed history of carcinogenicity. It is sometimes impHcated in an increased incidence of bladder cancer in animals and esophageal cancer in humans. Multiple other dietary components seem to either promote or interfere with its action, and the significance of braken fern in human carcinogenesis remains unproven. 

Not only is TCDO a potent therapeutic agent in acute radiation syndrome, but treatment using TCDO from days 4—11 after TBI increases the survival rate in rats for up to one year, protects against the development of late GI ulcers, and also reduces the development of y-ray-induced leukemias and malignant epitheHal tumors, but not sarcomas (202). The anticarcinogenic effect of TCDO maybe related to the inhibition of PGs, which promote carcinogenesis, or to immunostimulation, which may result in a more effective elimination of malignant cells. 

A scientifically evaluated and fully referenced data bank, developed and maintained by the National Cancer Institute (NCI). It contains some 8,000 chemical records with carcinogenicity, mutagenicity, tumor promotion, and tumor inhibition test results. Data are derived from studies cited in primaiy journals, current awareness tools, NCI reports, and other special sources. Test results have been reviewed by experts in carcinogenesis and mutagenesis. 

Wattenberg EV (2007) Palytoxin exploiting a novel skin tumor promoter to explore signal transduction and carcinogenesis, Am J Physiol Cell Physiol 292 C24—C32... 

Di-D-fructose dianhydrides have been claimed to promote the growth of bifidobacteria in vitro.134 Bifidobacterium spp. are found in the large intestines of most vertebrates.135 The benefits attributed to the presence of a healthy population of bifidobacteria in the gut include inhibition of carcinogenesis,136 suppression of putrefactive substances,137 lowering of blood pressure and blood... 

Fransson-Steen R, Rodstrom S, Warngard L. 1992. The insecticide endosulfan and its two stereoisomers promote the growth of altered hepatic foci in rats. Carcinogenesis 13(12) 2299-2303. 

Zhang J, Sarkar S, Yong VW (2005) The chemokine stromal cell derived factor-1 (CXCL12) promotes glioma invasiveness through MT2-matrix metalloproteinase. Carcinogenesis 26 2069-2077... 

DiziK M, CHRISTMAN J K andwAiNFAN E (1991) Alterations in expression and methylation of specific genes in livers of rats fed a cancer promoting methyl-deficient diet . Carcinogenesis, 12, 1307-12. 

Strong promoting activity of phenylethyl isothiocyanate and benzyl isothiocyanate on urinary bladder carcinogenesis in F344 male rats , Int J Cancer, 77 773-7. 

OGAWA K, HIROSE M, SUGIURA S, CUI L, IMAIDA K, OGISO T and SHIRAI T (2001) Dose-dependent promotion by phenylethyl isothiocyanate, a known chemopreventer, of two-stage rat urinary bladder and liver carcinogenesis , Nutr Cancer, 40 134-9. 

KATiYAR s K and MUKHTAR H (1997) Inhibition of phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate-caused inflammatory responses in SENCAR mouse skin by black tea polyphenols . Carcinogenesis, 18 1911-16. 

Nelson R.L. Chlorophyllin, an antimutagen, acts as a tumor promoter in the rat dimethylhydrazine colon carcinogenesis model. Anticancer Res., 12, 737, 1992. 

Zimmerman, R and Cerutti, P. (1984). Active oxygen acts as a promoter of carcinogenesis in C3H/10T1/2/C18 fibroblasts. Proc. Natl Acad. Sci. USA 81, 2085-2087. 

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