Carcinogenesis Liver

Yamasaki, H., Knitovskikh, V, Mesnil, M., Cohirabano, A., Tsuda, H., and Ito, N. (1993). Gap jurictional intercellular communication and cell proliferation during rat liver carcinogenesis. Academic diss.. University of Helsinki. 

OGAWA K, HIROSE M, SUGIURA S, CUI L, IMAIDA K, OGISO T and SHIRAI T (2001) Dose-dependent promotion by phenylethyl isothiocyanate, a known chemopreventer, of two-stage rat urinary bladder and liver carcinogenesis , Nutr Cancer, 40 134-9. 

Denda, A., Sai, K., Tang, Q., Tsujuchi, T., Tsutsumi, M., Amanuwa, T., Murata, Y., Nakoe, D., Maruyama, H., Kurokawa, Y. and Konishi, T. (1991). Induction of 8-hydroxydeoxyguanosine but not initiation of carcinogenesis by redox enzyme modulations with or without menadione in rat liver. Carcinogenesis 12, 719-726. 

Hinrichsen, L.I., Floyd, RA. and Sudilovsky, O. (1990). Is 8-hydroxydeoxyguanosine a mediator of carcinogenesis by a choline-devoid diet in the rat liver Carcinogenesis 11, 1879-1881. 

Abdellatif AG, Preat V, Taper HS, Roberfroid M (1991) The modulation of rat liver carcinogenesis by perfluorooctanoic acid, a peroxisome proliferator. Toxicol Appl Pharmacol 111(3) 530-537... 

Williams GM. 1981. Liver carcinogenesis The role for some chemicals of an epigenetic mechanisms of liver-tumor promotion involving modification of the cell membrane. Food Cosmet Toxicol 19(5) 577- 583. 

Ledda-Columbano GM, Columbano A, Coni P, et al. 1987a. Liver cell proliferation induced by the mitogen ethylene dibromide, unlike compensatory cell proliferation, does not achieve initiation of rat liver carcinogenesis by diethyinitrosoamine. Cancer Lett 36 247-252. 

Reddy TV, Daniel FB, Lin EL, et al. 1992. Chloroform inhibits the development of diethylnitrosamine-initiated, phenobarbital-promoted gamma-glutamyltranspeptidase and placental form glutathione S-transferase-positive foci in rat liver. Carcinogenesis 13(8) 1325-1330. 

Ito, N., R. Hasegawa. K. Imaida, Y. Kurata, A. Hagiwara, and T. Shirai. 1995. Effect of ingestion of 20 pesticides in combination at acceptable daily intake levels on rat liver carcinogenesis. Food Chem. Toxicol. 33 159-163. 

MLL4 (KMT2D) Involvement in viral (hepatitis B) liver carcinogenesis [92] H3K4... 

Columbano A, Ledda-Columbano GM, Ennas MG, et al. 1990. Cell proliferation and promotion of rat liver carcinogenesis different effect of hepatic regeneration and mitogen induced hypoerplasia on the development of enzyme- altered foci. Carcinogenesis 11 4771-776. 

Cloumbano A, Rajalakshmi S, Sarma DSR. 1981. Requirement of cell proliferation for the initiation of liver carcinogenesis as assayed by three different procedures. Cancer Res 41 2079-2083. 

Mirsalis JC, Steinmetz KL. 1990. The role of hyperplasia in liver carcinogenesis. In Mouse liver carcinogenesis mechanisms and species comparisons. Alan R. Liss, Inc., ed. 149-161. 

Two primary responses have been proposed to account for liver carcinogenesis in rats and mice by peroxisome proliferators. These are (i) induction of peroxisome... 

Lefevre, PA. Ashby, J. (1989) Evaluation of dichloromethane as an inducer of DNA synthesis in the B6C3F1 mouse liver. Carcinogenesis, 10, 1067-1072... 

Groups of 7-10 male Sprague-Dawley rats, weighing 200 g, were administered catechol (purity, > 98%) at concentrations of 0 or 100 mg/kg in the diet for six weeks beginning one week after partial hepatectomy and intraperitoneal injection of 30 mg/kg bw /V-nitrosodietliylamine to initiate liver carcinogenesis. Catechol after initiation did not increase the multiplicity of liver enzyme-altered (y-glutamyltranspeptidase) foci (Stenius et al., 1989). 

Harttig, U. and Bailey, G.S. 1998. Chemoprevention by natural chlorophylls in vivo Inhibition of dibenzo[a,l]pyrene-DNA adducts in rainbow trout liver. Carcinogenesis 9 1323-1326. 

Walker NJ, Miller BD, Kohn MC, et al. 1998. Differences in kinetics of induction and reversibility of TCDD-induced changes in cell proliferation and CYP1A1 expression in female Sprague-Dawley rat liver. Carcinogenesis 19 1427-1435. 

M.I.R. (1985) Interactions of Barbiturates and a Choline Deficient Diet in Promotion of Liver Carcinogenesis. This Volume. 

GerbrachtU, Einig C, Oesterle D, et al. 1990. Di(2-ethylhexyl)phthalate alters carbohydrate enzyme activities and foci incidence in rat liver. Carcinogenesis 11 (12) 2111-2115. 

Williams GM, Maruyama H, Tanaka T. 1987. Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-cthy 1 hcxyl)phthalate in rat liver carcinogenesis. Carcinogenesis 8(7) 875-880. 

D.E. Stevenson, J.A. Popp, J.M. Ward, R.M. McClain, T.J. Slaga, and H.C. Pitot, eds., Mouse liver carcinogenesis, Mechanisms and Species Comparisons, Wiley-Liss, New York, 1990. 

Anderson LM, Jones AB, Riggs CW, Ohshima M (1985) Fetal mouse susceptibility to transplacental lung and liver carcinogenesis by 3-methylcholanthrene Positive correlation with responsiveness to inducers of aromatic hydrocarbon metabolism. Carcinogenesis, 6(9) 1389-1393. 

Gelderblom WCA, Cawood ME, Snyman SD, Marasas WFO Fumonisin Bj dosimetry in relation to cancer initiation in rat liver. Carcinogenesis 1994 15 209-214. 

Murakoshi, M. et al.. Potent preventive action of a-carotene against carcinogenesis spontaneous liver carcinogenesis and promoting stage of lung and skin carcinogenesis in mice are suppressed more effectively by a-carotene than by P-carotene, Cancer Res., 52, 6583, 1992. 

Other studies in animal models show that a choline-deficient diet promotes liver carcinogenesis (256-261). In fact, choline is the only known nutrient for which deficiency is directly linked to liver cancer in the absence of any known carcinogen (262, 263). Choline deficiency is therefore considered to have both cancer initiating and cancer promoting activities. 

Iwamoto KS, Fujii S, Kurata A, Suzuki M, Hayashi T, Ohtsuki Y, Okada Y, Narita M, Takahashi M, Hosobe S, Doishita K, Manabe T, Hata S, Murakami I, Hata S, Itoyama S, Akatsuka S, Ohara N, Iwasaki K, Akabane H, Fujihara M, Seyama T, Mori T. p53 mutations in tumor and non-tumor tissues of Thorotrast recipients a model for cellular selection during radiation carcinogenesis in the liver. Carcinogenesis 1999 20(7) 1283-91. 

Standeven AM, Goldsworthy TL. 1993. Promotion of neoplastic lesions and induction of CYP2B induced by unleaded gasoline vapors in female B6C3F1 mouse liver. Carcinogenesis 14 2137-2141. 

Gillner M, Bergman J, Cambillau C, Gustafsson JA. 1989. Interactions of ru-taecarpine alkaloids with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver. Carcinogenesis 10 651-54... 

Williams GM, Iatropoulos MJ, Jeffrey AM. 2000. Mechanistic basis for non-linearities and thresholds in rat liver carcinogenesis by the DNA-reactive carcinogens 2-acetylaminofluorene and di-ethylnitrosamine. Toxicol. Pathol. 28 388-95... 

Laib RJ, Bolt HM. 1986. Vinyl acetate, a structural analog of vinyl carbamate, fails to induce enzyme-altered foci in rat liver. Carcinogenesis 7 841—43... 

---