Carcinogenesis concept

Snjiders PJ, Steenbergen RD, Heideman DA, Meijer CJ. HPV-mediated cervical carcinogenesis concepts and clinical implications. J Pathol 2006 208 152-64. 

Van Bekkum, D.W. and P. Bentvelzen, The Concept of Gene Transfer-Misrepair Mechanism of Radiation Carcinogenesis May Challange the Risk Estimation For Low Radiation Doses, Health Physics 43 231-237 (1982). 

Page, N.P. (1977). Concepts of a bioassay program in environmental carcinogenesis. In Environmental Cancer (Kraybill, H.F. and Mehlman, M.A., Eds.). Hemisphere Publishing, New York, pp. 87-171. 

Within the general concept of the somatic cell mutation theory, it is now clear that there are a number of different mechanisms underlying carcinogenesis. Thus, the carcinogen can interact with a number of processes, not only causing a mutation, but influencing DNA repair and cell proliferation, for example. Furthermore, it seems cancers arise from an accumulation of several mutations. 

Miller EC, Miller JA. The metabolism of chemical carcinogens to reactive electrophiles and their possible mechanism of action in carcinogenesis. In Searle CE, ed. Chemical Carcinogens. Washington D.C. American Chemical Society, 1976. A seminal article by the original authors of this important concept. 

The concept that inflammation and carcinogenesis are related phenomena has been the subject of many studies that have attempted to link these two processes in a mechanistic fashion [94-99]. In connection with this, as is evident in some triterpenoids such as oleanolic acid (142), glycyrrhetic acid (147), and ursolic acid (210) in Table 2, those possessing anti-inflammatory activity in various experimental models exhibited antitumor-promoting activity as well. This suggests that most of the other anti-inflammatory triterpenoids and sterols listed in Table 2 might have antitumor-promoting properties which have not been evaluated, yet. 

Lastly, nutrition education programs need to be coupled with an understanding that dietary factors are not the sole determinants of the risk of chronic diseases, with realistic expectations about the amount of time and effort required to modify food habits, and the likelihood of benefits. Conveying an understanding of the basic concepts about the process of carcinogenesis, its long latency period, and the importance of prevention would further enhance the success of such programs. 

TroskoJE. 2001. Commentaiy Is the concept of tumor promotion a useful paradigm Molec Carcinogenesis. 30 131-137. 

Cancer prevention is now one of the most urgent projects in public health. It is evident that an understanding of the mechanisms of the carcinogenesis process is essential for cancer chemoprevention. Most cancer prevention research is based on the concept of multistage carcinogenesis initiation —> promotion — progression [2-4] [Fig. (1)]. Cancer chemoprevention is defined as the use of specific natural and... 

Evaluates the two-stage concept of carcinogenesis (initiation and promotion)... 

Huff J, Haseman J, Rail D. Scientific concepts, value and significance of chemical carcinogenesis studies. Ann Rev Pharmacol Toxicol 1991 31 621-52. 

Brown, C.C. Mathematical aspects of dose response studies in carcinogenesis The concept of thresholds. Oncology, 1976,... 

The concept that cancer involves an alteration in the genetic material of a somatic cell (somatic mutation theory) was first introduced by Theodor Boveri in 1914. Boveri suggested that cancer was related to chromosome abnormalities in somatic cells. With respect to chemical carcinogenesis, James and Elizabeth Miller in the 1950 s and 1960s observed that a wide variety of structurally diverse chemicals could produce cancer in laboratory animals. They suggested that many of these diverse... 

Nieboer E, McBryde WAE (1970b) Free-energy relationships in coordination chemistry. 11. Requirements for linear relationships. Can J Chem 48 2565-2573 Nieboer E, McBryde WAE (1973) Free-energy relationships in coordination chemistry. 111. A comprehensive index to complex stabUity. Can J Chem 51 2512-2524 Nieboer E, MaxweU Rl, Rossetto FE, Stafford AR, Stetsko PI (1986) Concepts in nickel carcinogenesis. In Xavier AV (ed) Frontiers in bioinorganic Chemistry. VCH, Weinheim, pp S142-S151... 

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