Cancer growth inhibition

THE COMBINATION OF LYCOPENE WITH OTHER MOLECULES IN CANCER GROWTH INHIBITION... 

It is important to note that diet is a complex mixture that contain compounds with varying activity. Chemical stimulators of colon cancer growth include bile acids, 1,2-diglycerides and prostaglandins which stem from consumption of fat. In contrast, fruits and vegetables contain substances such as carotenoids, flavonoids and fibre, which may inhibit cancer cell growth, and the risk of colon cancer appears to be mirrored by the ratio of plant sterols to cholesterol in the... 

Growth inhibition by TGF- 3, associated with inhibition of c-myc, cdks, reduction in cyclin D1 levels, and inhibition of cdk-4-associated Rb kinase activity, as well as induction of cdk inhibitors pi5 and p27, has been noted in intestinal epithelial cells. Loss of responsiveness to growth inhibition from TGF- 3 occurs in many cell types including breast, colorectal carcinoma, and pancreatic carcinoma cells. Mutational inactivation of T 3RH represents one mechanism of this process, which in many cases, leads to the development of gastrointestinal cancer. Thirteen percent of colorectal carcinomas are thought to be associated with a replication error (RER) or microsatellite instability phenotype. Subsequent inactivation of T 3RII and... 

OKABE s, SUGANUMA M, HAYASHi M, SUEOKA E, KOMORI A and FUJIKI H (1997) Mechanisms of growth inhibition of hmnan lung cancer cell line, PC-9, by tea polyphenols , Jpn J Cancer Res, 88 (7), 639-43. 

Lee, J.I. et al., Beta-lapachone induces growth inhibition and apoptosis in bladder cancer cells by modulation of Bcl-2 family and activation of caspases, Exp. Oncol., 28, 30, 2006. 

Different types of apparently beneficial activities have been demonstrated in vitro for carotenoid oxidation products, including induction of gap-junctional communications, " growth inhibition of leukemia and cancer cells, induction of apoptosis... 

FIGURE 5.35 Growth inhibition assay of three human cancerous cell lines, with dendritic prodrug 38 in the presence ( ) and absence ( ) of PGA cells were incubated for 72 h. 

Table 7.3 shows the concentrations of 1-5 that result in 50% growth inhibition (GI50) of five human cancer cell lines. Inspection of these data reveals that cytostatic activity of 1 and 3-5 depends on the thermodynamic favorability of the quinone methide species compared to the corresponding keto form. The most cytostatic prekinamycins 1 and 5 are associated with the thermodynamically stable quinone methides. In contrast, the inactive prekinamycins 3 and 4 are associated with thermodynamically stable keto tautomers. The exception is prekinamycin 2, which is cytostatic and possesses a relatively stable keto tautomer 3 compared to its quinone methide. Although the AE value for quinone methide tautomerization can predict cytostatic properties, prekinamycin 2 shows that there must be other factors determining biological activity. 

To evaluate PARP inhibition in a realistic setting, olaparib (7) was tested in a BrcflI / p53 / mouse breast cancer model. Treatment with olaparib caused tumor growth inhibition without generating signs of toxicity [14]. Interestingly, upon cessation of treatment and tumor... 

Concern for the continued widespread use of chlordane centers on its ability to cause liver cancer in domestic mice. Other adverse effects in mammals, such as elevated tissue residues and growth inhibition, were frequently associated with diets containing between 0.76 and 5.0 mg chlordane/kg feed. Metabolism of technical chlordane by mammals results primarily in oxychlordane, a metabolite that is about 20 times more toxic than the parent compound and the most persistent metabolite stored in adipose tissues. Chlordane interactions with other agricultural chemicals produced significant biological effects in warm-blooded organisms, indicating a need for additional research on this subject. 

Mlerenes at 6 pM and white light to produce growth inhibition in human HeLa cancer cells. However, these same authors later reported that other carboxylic acid derivatives of C60 and C70 were completely without any photoactivity as PDT agents at 50pM (Irie et al., 1996). 

S. W. Lee, C. L. Reimer, P. Oh, D. B. Campbell, and J. E. Schnitzer. Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells. Oncogene 16 1391-1397 (1998). 

E. K. Sloan, K. L. Stanley, and R. L. Anderson. Caveolin-1 inhibits breast cancer growth and metastasis. Oncogene 23 7893-7897 (2004). 

Delaney CA, Wang LZ, Kyle S, White AW, Calvert AH, Curtin NJ, Durkacz BW, Hostomsky Z, Newell DR (2000) Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin Cancer Res 6 2860-2867... 

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