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Adenosine diphosphoribose

Delaney CA, Wang LZ, Kyle S, White AW, Calvert AH, Curtin NJ, Durkacz BW, Hostomsky Z, Newell DR (2000) Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin Cancer Res 6 2860-2867... [Pg.65]

Guse AH. Regulation of calcium signaling by the second messenger cyclic adenosine diphosphoribose (cADPR). Curr Mol Med. 2004 4 239-248. [Pg.51]

Fig. 2 Presynaptic mGluRs on human and rat neocortical cholinergic (ACh) nerve endings and effect of the HIV-1 protein Tat. In human neocortex, Tat activates mGluRl leading to inositol trisphosphate (IP3) production, IP3 receptor (IP3R) activation, mobilization of Ca2+ from the endoplasmic reticulum (ER), and vesicular ACh release. In rat neocortex ACh terminals Tat binds to an unidentified receptor whose activation also leads to ACh release. This release again is dependent on intraterminal Ca2+, but this is mobilized by ryanodine receptor (RYR) activation via the endogenous agonist cyclic adenosine diphosphoribose (cADPR). Fig. 2 Presynaptic mGluRs on human and rat neocortical cholinergic (ACh) nerve endings and effect of the HIV-1 protein Tat. In human neocortex, Tat activates mGluRl leading to inositol trisphosphate (IP3) production, IP3 receptor (IP3R) activation, mobilization of Ca2+ from the endoplasmic reticulum (ER), and vesicular ACh release. In rat neocortex ACh terminals Tat binds to an unidentified receptor whose activation also leads to ACh release. This release again is dependent on intraterminal Ca2+, but this is mobilized by ryanodine receptor (RYR) activation via the endogenous agonist cyclic adenosine diphosphoribose (cADPR).
Fig. 6. Sketch of the horse liver alcohol dehydrogenase-adenosine-diphosphoribose (ADPR) binary complex in the region of the active site. ADPR lies in an 20 A-deep cavity which extends to the metal ion as indicated). The second cavity ( 20 A deep also) is believed to be the substrate binding site (47)... Fig. 6. Sketch of the horse liver alcohol dehydrogenase-adenosine-diphosphoribose (ADPR) binary complex in the region of the active site. ADPR lies in an 20 A-deep cavity which extends to the metal ion as indicated). The second cavity ( 20 A deep also) is believed to be the substrate binding site (47)...
Berger NA, Weber G, Kaichi AS (1978) Relation of poly(adenosine diphosphoribose) synthesis to DNA synthesis and cell growth. Biochim Biophys Acta 519 87-104... [Pg.128]

Burzio LO, Reich L, Koide SS (1975) Poly (adenosine diphosphoribose) synthase activity of isolated nuclei of normal and leukemic leukocytes. Proc Soc Exp Biol Med 149 933—938... [Pg.146]

Berger NA, Sikorski GW (1981) Poly (adenosine diphosphoribose) synthesis in ultra-violet irradiated Xeroderma Pigmentosum cells reconstituted with micrococcus luteus UV endonuclease. Biochemistry 20 3610-3614... [Pg.187]

Berger NA, Sikorski GW, Petzold SJ, Kurohara KK (1979) Association of poly(adenosine diphosphoribose) synthesis with DNA damage and repair in normal human lymphocytes. J Clin Invest 63 1164-1171... [Pg.250]

Zwelling LA, Kerrigan D, Pommier Y (1982) Inhibitors of poly(adenosine diphosphoribose) synthesis slow the resealing rate of X-ray-induced DNA strand breaks. Biochim Biophys Res Commun 104 897-902... [Pg.331]

Caplan AI, Rosenberg MJ (1975) Interrelationship between poly (adenosine diphosphoribose) synthesis, intracellular NAD levels and muscle or cartilage differentiation from embryonic chick limb mesodermal cells. Proc Natl Acad Sci USA 72 1852-1857... [Pg.395]

Arrest of Tumor Growth by DNA-Site Inhibitors of Adenosine Diphosphoribose Transferase... [Pg.250]

The interrelationships described above provide a basis for evaluating the possibility that chemotherapeutic or metabolic manipulation can be used to produce drastic alterations in ceU functions. We have shown that one mechanism of cell death, which we have called Type 1 or the Suicide mechanism, is mediated by activation of poly(ADP-ribose) polymerase and the consequent depletion of cellular energy metabolites (1,2). This enzyme is activated by DNA strand breaks to cleave NAD at the glycosylic bond between the nicotinamide and adenosine diphosphoribose moieties (3). The latter are joined by the same enzyme into linear or branched chain polymers of ADP-ribose (3). Poly(ADP-ribose) polymerase activity and utilization of its substrate, NAD, are proportional to the number and duration of DNA strand breaks (4, 5). As shown in Fig. 2, DNA damage can sufficiently... [Pg.367]

R = Adenosin-diphosphoribose Figure 7.31. Redox equilibrium of nicotinamide adenine dinucleotide (NAD)... [Pg.183]

Durkacz, B.W., Omidiji, O., Gray, D.A., and Shall, S., (ADP-ribose)n participates in DNA excision repair. Nature, 283, 593, 1980 Zhao, B., Konno, S., Wu, J.M., and Oronsky, A.L., Modulation of nicotinamide adenine dinucleotide and poly(adenosine diphosphoribose) metabolism by cali-cheamicin yl in human HL-60 cells. Cancer Lett., 50,141,1990. [Pg.617]

See other pages where Adenosine diphosphoribose is mentioned: [Pg.47]    [Pg.415]    [Pg.415]    [Pg.43]    [Pg.65]    [Pg.255]    [Pg.183]    [Pg.79]    [Pg.326]    [Pg.142]    [Pg.2]    [Pg.20]   


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