Genital cancer

Intron A (rIFN-a-2b) Schering Plough Cancer, genital warts, hepatitis... 

Depot medroxyprogesterone acetate should not be used in women with breast cancer, genital cancer, undiagnosed uterine bleeding, or suspected pregnancy (37), but these are merely logical precautions. 

Intron A (rIFN-a2b produced in E. coli) Sobering Plough cancer, genital warts, hepatitis 1986 (US), 2000 (EU)... 

Papilloma virus (HPV) Cervical and colon cancer, genital warts... 

In order to discuss the biological mechanisms involved in the aetiology of genital tract malformations, testicular cancer and lowered sperm counts, some knowledge of the processes involved in the differentiation and development of the male reproductive tract and determination of normal testicular function is required. An early embryo has the potential to develop either a male or a female... 

The presence of human papilloma virus (HPV) is associated with female genital tract diseases such as condyloma, Bowenoid papulosis, and cervical, vaginal, and vulvar intraepithelial neoplasia and carcinoma. A general concern is the association of HPV with cervical cancer (Gl). The HPV consists of an icosahedral viral particle (virion) containing 8000 base pairs, a circular, double-stranded piece of DNA surrounded by a protein capsid. Viral replication takes place within the nuclei of infected squamous epithelial cells (H5). Following infection of epithelial cells, the viral DNA penetrates throughout the entire thickness of the epithelium, but intact viruses are found only in the upper layers of tissue. 

Gl. Gissman, L., Identification of human papilloma virus in genital tumors. Cancer Sum. 3, 161 — 181 (1984). 

Cervical Cancer. In female AIDS patients, cancer of the cervix is observed with high frequency. Cervical cancer is a fairly common cancer in women, although it typically affects women of middle age or older. Infection with certain strains of human papilloma virus (HPV) that cause warts in the genital tract is an underlying cause of cervical cancer. 

In recent years it seems that AIDS has somewhat eclipsed other sexually transmitted diseases. A problem, however, is that sexually transmitted diseases not only cause ill health in their own right, but can have long-term consequences including infertility, ectopic pregnancy and genital cancers. Consequently, there is increasing concern about... 

In short-term renal toxicity studies in rats gavage administration of 1,1,2,2-tetra-chloroethane caused renal toxicity as evidenced by an increased renal tubule cell labeling index, indicating replicative DNA synthesis. In 2-year studies 1,1,2,2-tetrachloroethane administered by gavage produced an increased incidence of hepatocellular carcinomas in mice but not in rats. In one epidemiological study of exposed army workers there was a slight increase in deaths due to genital cancer and leukemia. Exposure levels were not available,... 

In women with lower-genital-tract carcinomas—cervical, vaginal, and vulvar carcinomas—hematogenous metastases are rarely present at diagnosis, and thus disease can frequently be controlled with local treatment. Small tumors can usually be treated with surgery alone, but cancers that penetrate deeply, particularly those that involve adjacent... 

Contraindications Breast cancer, cerebral apoplexy or history of these conditions, severe liver dysfunction, thromboembolic disorders, thrombophlebitis, undiagnosed vaginal bleeding, genital malignancy... 

IFN-a may be used for the treatment of condylomata acuminata (venereal or genital warts), malignant melanoma, hairy cell leukemia and hepatitis B and C, and other types of cancer including skin, kidney and bone cancers. 

Long-term data are also accumulating on the actual incidence of genital cancer in women exposed to diethylstilbestrol in utero (38). In the Netherlands, a country in which diethylstilbestrol was used intensively in pregnancy, there is evidence that the risk of cervical cancer in these women is trebled, rather than doubled as was previously supposed (39). 

Herbst AL. Behavior of estrogen-associated female genital tract cancer and its relation to neoplasia following intrauterine exposure to diethylstilbestrol (DES). Gynecol Oncol 2000 76(2) 147-56. 

---