Brush-type

When electrical conductivity is used as the basis of the sorting process, contact of the particles is made by a brush type of electrode to generate the signal for analysis. Materials having a resistance difference of 2000 kn can be readily separated from material of 100 kH resistance. 

Another concept is brushless excitation, in which an ac generator (exciter) is direc tfy coupled to or mounted on the motor shaft. The ac exciter has a stator field and an ac rotor armature which is directly connected to a static controllable rectifier on the motor rotor (or a shaft-mounted drum). Static control elements (to sense synchronizing speed, phase angle, etc.) are also rotor-mounted, as is the field discharge resistor. Changing the exciter field adjusts the motor field current without the necessity of brushes or slip rings. Brushless excitation is suitable for use in hazardous atmospheres, where conventional brush-type motors must have protective brush and slip-ring enclosures. 

Since static discharges frequently occur at the liquid interface as liquid drains from the wetted wall, a vapor ignition hazard may also exist [ 157,159]. These discharges may be either brush types or PBDs (2-6.2 and 2-6.5). In 1997 it was concluded that Manufacturers have so far not paid attention to requests by the operators of enamel apparatus for a coating which is completely or partially capable of dissipation [159]. However, this situation is believed to be changing and it might now be possible to specify special static dissipative coatings for the vessel and stirrer. 

In contrast, the alkane chains on the polymeric phase cannot collapse in an environment of water as they are rigidly held in the polymer matrix. Thus, the retention of the solute now continuously falls as the methanol concentration increases as shown in Figure 4. It should be pointed out that if the nature of the solutestationary phase interactions on the surface of a bonded phase is to be examined in a systematic manner with solvents having very high water contents, then a polymeric phase should be used and brush type reversed phases avoided if possible. 

The majority of the original chiral selectors for brush-type CSPs were derived from natural chiral compounds. Selectors prepared from amino acids, such as phenyl... 

Fig. 6-9. Imprintable brush-type selectors. (From Welch [70].)...

The high diffusivity and low viscosity of sub- and supercritical fluids make them particularly attractive eluents for enantiomeric separations. Mourier et al. first exploited sub- and supercritical eluents for the separation of phosphine oxides on a brush-type chiral stationary phase [28]. They compared analysis time and resolution per unit time for separations performed by LC and SFC. Although selectivity (a) was comparable in LC and SFC for the compounds studied, resolution was consistently... 

Cellulose derivatives Amylose derivatives Brush-type... 

The brush-type (Pirkle-type) CSPs have been used predominantly under normal phase conditions in LC. The chiral selector typically incorporates tt-acidic and/or n-basic functionality, and the chiral interactions between the analyte and the CSP include dipole-dipole interactions, n-n interactions, hydrogen bonding, and steric hindrance. The concept of reciprocity has been used to facilitate the rational design of chiral selectors having the desired selectivity [45]. 

A new brush-type CSP, the Whelk-0 1, was used by Blum et al. for the analytical and preparative-scale separations of racemic pharmaceutical compounds, including verapamil and ketoprofen. A comparison of LC and SFC revealed the superiority of SFC in terms of efficiency and speed of method development [50]. The Whelk-0 1 selector and its homologues have also been incorporated into polysiloxanes. The resulting polymers were coated on silica and thermally immobilized. Higher efficiencies were observed when these CSPs were used with sub- and supercritical fluids as eluents, and a greater number of compounds were resolved in SFC compared to LC. Compounds such as flurbiprofen, warfarin, and benzoin were enantioresolved with a modified CO, eluent [37]. 

Methanol remains the most widely used modifier because it produces highly efficient separations, but it does not always produce the highest selectivity [8]. Recent studies have provided insight into the role of the modifier in enantioselectivity in SFC [69]. Blackwell and Stringham examined a series of phenylalanine analogues on a brush-type CSP and developed a model that allowed prediction of selectivity based on the bulk solvation parameters of various modifiers [70]. Careful choice of modifiers can be used to mask or enhance particular molecular interactions and ultimately provide control of selectivity [71]. 

The most popular bonded phases are, without doubt, the reverse phases which consist solely of aliphatic hydrocarbon chains bonded to the silica. Reverse phases interact dispersively with solvent and solute molecules and, as a consequence, are employed with very polar solvents or aqueous solvent mixtures such as methanol/water and acetonitrile/water mixtures. The most commonly used reverse phase appears to be the brush type phase with aliphatic chains having four, eight or eighteen carbon atom chains attached. These types of reverse phase have been termed C4, C8 and Cl8 phases respectively. The C8... 

Brush-type Antimalarials, NSAIDs, P-blockers, bronchodilators... 

A conical pile discharge (Figure 7-9) is a form of a brush-type discharge that occurs at the conical surface of a pile of powder.5 The necessary conditions for this discharge are (1) a pow-... 

An understanding of the recognition of chirality at a molecular level has become of interest in many fields of chemistry and biology. In the past decade, many attempts to clarify the mechanism of chiral recognition on CSPs for liquid chromatography have been made by means of chromatography, NMR spectroscopy,199 202 X-ray analysis, and computational methods.203 - 206 The successful studies have been mostly carried out for the small-molecule CSPs, especially cyclodextrin-based CSPs and Pirkle-type (brush-type) CSPs. In contrast, only a few mechanistic studies on chiral discrimination at the molecular... 

The concept of making brush-type polymers in which a linear polymer is funtionalized with dendritic side-chains was first suggested by Tomalia in a 1987 patent, though actual experimental work on his approach was only reported recently recently [15]. Hawker and Frechet were first to document the preparation of a vinyl copolymer containing a few pendant Frechet-type dendrons (Figure 7.9). 

New brush-type phases (donor-acceptor interactions) are appearing all the time. " Examples are stationary phases comprising quinine derivatives and trichloro-dicyanophenyl-L-a-amino acids as chiral selectors. Quinine carbamates, which are suitable for the separation of acidic molecules through an ionic interaction with the basic quinine group, are also commonly used but in general they are classified with the anion-exchange type of chiral selectors (see further) because of their interaction mechanism, even though r-donor, r-acceptor properties occur. (Some separations on Pirkle-type CSPs are shown in Table 2.)... 

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