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Chiral compounds natural

Cellulose represents an important polymer, which is most abundant in nature, and serves as a renewable resource in many applications, e.g., fibers, films, paper, and as a composite with other polysaccharides and lignin in wood. Cellulose derivatives will also be used as films and fibers, food additives, thermoplastics, and construction materials, to name just a few. Cellulose and cellulose derivatives have played an important role in the development of the macromolecular concept. So far, little use has been made of the fact that cellulose represents a chiral material except, e.g., in a rare case as stationary material in liquid chromatography for the separation of chiral compounds. Nature ifself uses the chirality of cellulose occasionally, and twisted structures of cellulose molecules are found in cell walls. [Pg.453]

The introduction of synthetic materials into natural products, often described as adulteration , is a common occurrence in food processing. The types of compounds introduced, however, are often chiral in nature, e.g. the addition of terpenes into fruit juices. The degree to which a synthetic terpene has been added to a natural product may be subsequently determined if chiral quantitation of the target species is enabled, since synthetic terpenes are manufactured as racemates. Two-dimensional GC has a long history as the methodology of choice for this particular aspect of organic analysis (38). [Pg.65]

The majority of the original chiral selectors for brush-type CSPs were derived from natural chiral compounds. Selectors prepared from amino acids, such as phenyl... [Pg.59]

The great majority of known chiral compounds are naturally occurring organic substances, their molecules having one or more asymmetrically substituted carbon atoms (stereogenic atoms). Chirality is present when a tetrahedrally coordinated atom has... [Pg.83]

New modifiers have traditionally been discovered by the trial-and-error method. Many naturally occurring chiral compounds (the chiral pool38) have been screened as possible modifiers. Thus, the hydrogenation product of the synthetic drug vinpocetine was discovered to be a moderately effective modifier of Pt and Pd for the enantioselective hydrogenation of ethyl pyruvate and isophorone.39 Likewise, ephedrine, emetine, strychnine, brucine, sparteine, various amino acids and hydroxy acids, have been identified as chiral modifiers of heterogeneous catalysts.38... [Pg.109]

Over the years of evolution, Nature has developed enzymes which are able to catalyze a multitude of different transformations with amazing enhancements in rate [1]. Moreover, these enzyme proteins show a high specificity in most cases, allowing the enantioselective formation of chiral compounds. Therefore, it is not surprising that they have been used for decades as biocatalysts in the chemical synthesis in a flask. Besides their synthetic advantages, enzymes are also beneficial from an economical - and especially ecological - point of view, as they stand for renewable resources and biocompatible reaction conditions in most cases, which corresponds with the conception of Green Chemistry [2]. [Pg.529]

Supported palladium and platinum modified by chiral compounds are largely used as pure heterogeneous hydrogenation catalysts. However, recent studies have been performed starting with catalysts of colloidal nature and particles with dimensions of only a few nanometers. Their development continues to attract substantial interest for three main reasons ... [Pg.249]

Naturally occurring chiral compounds provide an enormous range and diversity of possible starting materials. To be useful in asymmetric synthesis, they should be readily available in high enantiomeric purity. For many applications, the availability of both enantiomers is desirable. Many chiral molecules can be synthesized from natural carbohydrates or amino acids. The syntheses of (+)-exo-brevicomin (66) and negamycin (67) illustrate the application of such naturally occurring materials. [Pg.49]

In principle, asymmetric synthesis involves the formation of a new stereogenic unit in the substrate under the influence of a chiral group ultimately derived from a naturally occurring chiral compound. These methods can be divided into four major classes, depending on how this influence is exerted (1) substrate-controlled methods (2) auxiliary-controlled methods (3) reagent-controlled methods, and (4) catalyst-controlled methods. [Pg.50]

In the search for unique properties, chemists have isolated pertinent compounds, for which they have revealed the structures and in many cases developed syntheses. For many, in general, simpler compounds, industrially feasible preparations have also been worked out. However, for most of the more complex structures, nature proves to be much more efficient and cheaper, especially in the field of chiral compounds. Therefore, nature is still the supplier of many natural products, which are useful as such or as starting materials for other chemicals and auxiliaries in new chemical reactions. [Pg.101]

An obvious way to target chiral compounds is to start with a compound in which the chiral center is already present. Here natural products and derivatives offer a rich pool of generally inexpensive starting materials. Examples include L-hydroxy and amino adds. Sometimes, just one out of many chiral centers is predestined to remain, as in the synthesis of vitamin C from D-glucose, or in the preparation of (S)-3-hydroxy-y-butyrolactone from ladose. [Pg.113]

This chapter covers only the chiral compounds that are cited in the literature by virtue of their optical activity. To keep the chapter to an acceptable length, a discussion of the stereochemical properties of sulfenamides showing axial chirality is omitted (17). Similarly, to limit the scope of the review, the chemistry of penicillin, cephalosporin sulfoxides and related compounds (14,18,19), steroidal sulfoxides (15,16), and other naturally occurring chiral sulfur compounds (4) is not discussed. For the same reason, only selected results are discussed and in some cases only references are given to recent papers and review articles on special topics. [Pg.335]

Since the natural target of macrocyclic antibiotics is the A-acyl-D-alanyl-D-alanine terminus (see Section 2.1), the early choice of suitable substrates for this kind of CSPs was that of amino acids [45]. However, it turned out that the macrocyclic CSPs were very successful not only in amino acids enantioresolution, but also in the separation of a wide variety of different structures. The early stages of application of macrocyclic antibiotics have been surveyed in the different fields of chromatography [1,2]. A summary of the different categories of chiral compounds separated by HPLC on glycopeptides containing CSPs is reported in Table 2.3. [Pg.138]


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Nature, chirality

Use of naturally occurring chiral compounds as building blocks

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