Brain serotonin receptors

Essman, E.J., and Valzelli, L. Regional brain serotonin receptor changes in differentially housed mice Effects of amphetamine. Pharmacol Res Commun 16 401-408, 1984. 

Battaglia, G. Kuhar, M.J. and De Souza, EB. MDA and MDMA (ecstasy) interactions with brain serotonin receptors and uptake sites In vitro studies. Abstr Soc Neurosci 12 1234, 1986. 

Titeler. M. Lyon, R.A. Davis, K.A. and Glennon, R.A. Selectivity of serotonergic drugs for multiple brain serotonin receptors The role of H-DOB, a 5-HT2 agonist radioligand. Biochem Pharmacol 36 3265-3271,... 

Murphy DL Neuropsychiatric disorders and the multiple human brain serotonin receptor subtypes and subsystems. Neuropsychopharmacology 3 457, 1990 Murphy DL, Beigel A, Weingartner H, et al The quantification of manic behavior, in Psychological Measurements in Psychopharmacology. Edited by Pichot P. Basel, Switzerland, Karger, 1974a, pp 203-220... 

Palacios JM, Mengod G, Hoyer D. Brain serotonin receptor subtypes radioligand binding assays, second messengers, ligand autoradiography, and in situ hybridization histochemistry. Methods Neurosci 1993 12 238-261. 

A number of studies were concerned with the possible relationship of serotonin and cholesterol levels. Heron et al.176 reported that by increasing the cholesterol content in the synaptic membranes of mouse brain, serotonin receptors increased markedly. In contrast, in lowering the cholesterol concentration, the number of serotonin receptors and binding of serotonin to brain membranes decreased. These findings were consistent with the concept that serum cholesterol may influence the function of serotonin in the central nervous system.177... 

Other drugs The anxiolytic ding buspirone interacts with the S-HT, subclass of brain serotonin receptors as a partial agonist, but the precise mechanism of its anxiolytic effect is unknown. The hypnotics zolpidem and zaleplon are not benzodiazepines but appear to exert their CNS effects via interaction with certain benzodiazepine receptors, classified as BZ, or omega, subtypes their CNS depressant effects are antagonized by flumazenil. 

Perou a, S.J., and Snyder, S.H. Two distinct serotonin receptors Regional variations in receptor binding in mammalian brain. Brain Res 208 339-347, 1981. 

Yatham, L.N., Liddle, P. F. Dennie, J. (1999). Decrease in brain serotonin 2 receptor binding in patients with major depression following desipramine treatment a positron emission tomography study with fluorine-18-labeled setoperone. Arch. Gen. Psychiatry, 56, 705-11. 

Riad, M., Garcia, S Watkins, K. C. et al. (2000). Somatodendritic localization of 5-HTla and preterminal axonal localization of 5-HTlb serotonin receptors in adult rat brain. ]. Comp. Neurol. 417, 181-94. 

Histaminergic neurons can regulate and be regulated by other neurotransmitter systems. A number of other transmitter systems can interact with histaminergic neurons (Table 14-1). As mentioned, the H3 receptor is thought to function as an inhibitory heteroreceptor. Thus, activation of brain H3 receptors decreases the release of acetylcholine, dopamine, norepinephrine, serotonin and certain peptides. However, histamine may also increase the activity of some of these systems through H, and/or H2 receptors. Activation of NMDA, p opioid, dopamine D2 and some serotonin receptors can increase the release of neuronal histamine, whereas other transmitter receptors seem to decrease release. Different patterns of interactions may also be found in discrete brain regions. 

Bennett, J. P., Jr., and Snyder, S. H. (1975) Stereospecific binding ofD-lysergic acid diethylamide (LSD) to brain membranes Relationship to serotonin receptors. Brain Res., 94 523-544. 

Palacios, J. M., Probst, A., and Cortes, R. (1983) The distribution of serotonin receptors in the human brain High density of 3H-LSD binding sites in the raphe nuclei of the brain stem. Brain Res., 274 150-155. 

Ecstasy produces its effects by causing massive amounts of serotonin and dopamine to be released from neurons in the brain. In addition, Ecstasy inhibits the ability of neurons to reabsorb these neurotransmitters after they are secreted. This has the overall effect of dramatically increasing the stimulation of serotonin receptors on nearby neurons. Ecstasy affects numerous brain regions, as described in Table 3.1 ... 

Kiefei JM, Cooper ML, Bodnar RJ. (1992b). Serotonin receptor subtype antagonists in the mediai ventrai meduiia inhibit mesencephaiic opiate anaigesia. Brain Res. 597 331-38. 

Sershen H, Hashim A, Lajtha A. (1997). Ibogaine and cocaine abuse pharmacoiogicai interactions at dopamine and serotonin receptors. Brain Res Bull. 42(3) 161-68. 

Xu Z, Seidler FJ, et al (2002) Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase. Brain Res 951(2) 280-292 Xu Z, Seidler FJ, et al (2003) Sex-selective hippocampal alterations after adolescent nicotine administration effects on neurospeciflc proteins. Nicotine Tob Res 5(6) 955-960 YUmaz O, Kanit L, et al (1997) Effects of nicotine on active avoidance learning in rats sex differences, Behav Pharmacol 8(2-3) 253-260... 

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