Binding stereospecific

Abalis, I.M., Eldefrawi, M.E., and Eldefrawi, A.T. (1985). High affinity stereospecific binding of cyclodiene insecticides and gamma HCH to GABA receptors in rat brain. Pesticide Biochemistry and Physiology, 24, 95-102. 

Hampton, R.Y. Medzihradsky, F. Woods, J.H. and Dahlstrom, P.J. Stereospecific binding of 3H-phencyclidine in brain membranes. 

Calligaro, D.O. and Eldefraei, M.E., High affinity stereospecific binding of pH]cocaine in striatum and its relationship to the dopamine transporter, Membr. Biochem., 1, 87, 1988. 

We synthesized and reported the first crystal structures of Pt(IV)-diazidodiam(m)ine compounds and showed that they also could be activated with visible light to give rapid and stereospecific binding of the nucleotide 5 -GMP (28) (Fig. 6). The X-ray crystal structures of cis,cis,t7uns-[Pt(N.3)2(NH3)2(OH)2] (4) and cis, trcms-[Pt(en)(N3)2(OH)2] (5) show that the metal ion has a close to octahedral coordination geometry with almost linear... 

Bennett, J. P., Jr., and Snyder, S. H. (1975) Stereospecific binding ofD-lysergic acid diethylamide (LSD) to brain membranes Relationship to serotonin receptors. Brain Res., 94 523-544. 

It is now well understood that all glycopeptide antibiotics exert antibiotic activity against Gram-positive bacteria because they stereospecifically bind to the precursor peptidoglycan peptide terminus A-acyl-o-alanyl-D-alanine produced during bacterial... 

Abalis IM, Eldefrawi ME, Eldefrawi AT. 1985. High-affinity stereospecific binding of cyclodiene insecticides and y-hexachlorocyclohexane to y-aminobutyric acid receptors of rat brain. Pestic Biochem Physiol 24 95-102. 

Externally, the highly stereospecific binding or permease step P,... 

The extraordinary specificity of enzymatic catalysis is due to the shape recognition. Enzymes are proteins having a stereospecific binding site. At this site, the two reactants (in the above example, D-glucose and oxygen) are brought together in a precise and favorable orientation for the reaction to take place. 

Fig. 16 A Self assembling of G-quadruplex chiral aggregates and their stacking by interposition of cations. B Stereospecific binding of Ba2+ cations to give homochiral G-quadruplex, while K+ leads to heterochiral aggregates...

The chirality of DNA was applied to selective separation. A DNA aptamer as a new target-specific chiral selector for HPLC was investigated by Michaud et al. [119,120]. They showed that a tailor-made chiral stationary phase based on a DNA aptamer with known stereospecific binding for the D-enantiomer of the oligopeptide, arginine-vasopressin, exhibits enantioselectivity between the d- and L-peptides. This DNA-based target-specific aptamer chiral stationary phase provides a powerful tool for the resolution of small (bioactive) molecule enantiomers. 

An e.s.r. study has been made of the kinetics of stereospecific binding of morphine in an exploration of the opiate receptor of the synaptosome. Morphine that is spin-labelled at C-3 or C-6 with the group (159) was used as the opiate... 

In connection with his investigations of the importance of nitrogen nonbonding electron orientation in morphinans to their stereospecific binding to opioid receptors, Belleau(149) reported a D-ring contracted morphinan (142a), but without synthetic details (see Chapter 13 p. 465). 

Naloxone, prepared in eight steps from (+)-7-bromodihy-drocodeinone dimethyl ketal (26% overall yield), proved virtually inactive in three test systems (binding, GPI, and neuroblastoma x glioma hybrid cell adenylate cyclase assays) and can thus be used to establish the stereospecific binding of the natural levo isomer.(37) Both antipodes of naloxone are available from a total synthesis of morphinans starting from optically active 1-benzyl-isoquinolines.(128)... 

QSAR quantitative structure-activity relationships R(S) Rectus (Sinister) configurational symbols of the Cahn-Ingold-Prelog protocol RTC rat tail clip assay RTF rat tail-flick assay RTA/A rat tail-flick antagonist assay RTP rat tail pressure assay SAR structure-activity relationships sc subcutaneous SSB stereospecific binding TFA trifluoroacetic acid Ts tosyl(p-tolylsulfonyl)... 

Beld, A.J., Arlens, E.J. 1974 Stereospecific Binding as a Tool in Attempts to Localize and Isolate Muscarinic Receptors. Part II. Binding of ( t>)-Benzetlmlde, (-)-Benzetlmlde and Atropine to a Fraction from Bovine Tracheal SStooth Mascle and to Bovine Caudate Nucleus. Europ. J. azmacol. 25 203-209 ... 

Benzodiazepines, barbiturates, and alcohol act by stereospecifically binding to recently discovered receptors in the CNS. The effects of CNS-effective sedative-hypnotics have generally been linked to this complex, which also contains the receptor for y-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain and the chloride ion channel, through which chloride ions pass. ... 

Certain molecules, such cis naturally occurring ionophores and synthetic crown ethers, can recognize and bind metal ions, often fairly specifically. Enzymes are proteins that fold in a way that accomplishes this stereospecific binding of required molecules. 

Opiate narcotics are thought to act at specific receptors in the brain since they exhibit stereospecific binding (1) and have been shown by fluorescence techniques to be localized at discrete regions in the central nervous system (2). While much effort has been made to isolate and characterize the opiate receptor C3), relatively little detailed information exists about the nature of the opiate binding site. Some investigators describe the receptor as a membrane bound protein or proteo-lipid (4) while others have used nerve cell components such as cerebroside sulfate or phosphatidyl inositol as models for the opiate receptor (5). 

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