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Limbic brain regions serotonin receptors

Another problem in validating targets for behavioral disorders related to neurotransmitter abnormalities is the interplay between several neurotransmitter systems in specific brain regions. For example, in the hippocampus, limbic, and nigral-striatal areas, functions connected by serotonin, norepinephrine, and dopamine are interconnected so that blocking selected receptor subtypes or changing synaptic levels of certain neurotransmitters may... [Pg.228]

The role of serotonin (5-hydroxytryptamine, 5-HT) has also been extensively studied in depressed patients. Whereas the overall psycho-physiological effects of noradrenaline in the CNS appear to be linked to drive and motivation, 5-HT is primarily involved in the expression of mood. It is not surprising therefore to find that the serotonergic system is abnormal in depression. This is indicated by a reduction in the main 5-HT metabolite, 5-hydroxy indole acetic acid (5-HIAA), in the cerebrospinal fluid of severely depressed patients and a reduction in 5-HT and 5-HIAA in the limbic regions of the brain of suicide victims. The 5-HT receptor function also appears to be abnormal in depression. This is indicated by an increase in the density of cortical 5-HT2a receptors in the brains of suicide victims and also on the platelet membrane of depressed patients. Platelets may be considered as accessible models of the nerve terminal. [Pg.157]


See other pages where Limbic brain regions serotonin receptors is mentioned: [Pg.40]    [Pg.383]    [Pg.355]    [Pg.137]    [Pg.542]    [Pg.926]    [Pg.272]    [Pg.92]    [Pg.158]    [Pg.1287]    [Pg.115]    [Pg.360]    [Pg.891]    [Pg.158]   
See also in sourсe #XX -- [ Pg.30 , Pg.383 ]




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Limbic brain regions

Limbic region

Serotonin receptor

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