Polyethylene glycol -conjugated

Experimental in vitro investigations utilizing liposomal-encapsulated and polyethylene glycol-conjugated SOD and catalase have demonstrated the potential value of such means in countering oxidative asbestos-related diseases (Freeman etal., 1985 Mossman etal., 1986). In addition to using supplementary endogenous antioxidant enzymes, the use of iron chelators like desferrioxamine... 

Liu, T.H., Beckman, J.S., Freeman, B.A., Hogan, E.L. and Hsu, C.Y. (1989). Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury. Am. J. Physiol. 256, H589-593. 

Parveen S, Sahoo SK. Nanomedicine clinical applications of polyethylene glycol conjugated proteins and drugs. Clin Pharmacokinet 2006 45 966-88. 

Bendele A, Seely J, Richey C, et al. Short communication renal tubular vacuolation in animals treated with polyethylene-glycol-conjugated protein. Tox Sci 1998 42 152. 

D. H. Paper, R. Mulhaupt, and F. Kratz. 1999. Acid-sensitive polyethylene glycol conjugates of doxorubicin preparationjn vitro ef cacy and intracellular distributiorBiorg. Med. Chem.7 2517-2524. 

Lee M, Kim SW (2005) Polyethylene glycol-conjugated copolymers for plasmid DNA delivery. Pharm Res 22 1-10... 

K.L. Shum, and R.B. Greenwald. 2003. Utility of polyethylene glycol) conjugation to create prodrugs of amphotericin B. Bioconjug. Chem. 14 661-666. 

Hawkins, D. S., Park, J. R., Thomson, B. G., Felgenhauer, J. L., Holcenberg, J. S., Panosyan, E. H. and Avramis, V. I. (2004). Asparaginase pharmacokinetics after intensive polyethylene glycol-conjugated L-asparaginase therapy for children with relapsed acute lymphoblastic leukemia. Clin. Cancer Res. 10, 5335-5341. 

A. E, Mat, G. Sel vesen, R P. Schnebli, and V. Kzzo. Evaluation of the rapid plasma elimination of recombinant alpha 1-proteinase inhibitor synthesis of polyethylene glycol conjugates with improved therapeutic potential. /. Lab. din. Med. 116 58 (1990). 

A polyethylene glycol-conjugated hemoglobin derivative and carbon monoxide carrier, CO-MP4, is able to deliver CO to the circulation and reduces ischemia/ reperfusion injury in rats, providing the first evidence for this drug as a CO therapeutic agent [191, 192]. 

Further clinical evidence of the role of free radicals in head injury has been provided by the recently published results of a phase II trial of polyethylene glycol-conjugated SOD in severe head injury (Glasgow Coma Scale = 3-8). In the SOD-treated patients, there was a significant decrease in the number of patients who had died or persisted in a vegetative state at 3 or 6 months post-injury [67]. A phase III trial is underway. 

Moghimi, S. M., Hamad, I., Andresen, T. L., Jorgensen, K., and Szebeni, J. (2006), Methylation of the phosphate oxygen moiety of phospholipid-methoxy(polyethylene glycol) conjugate prevents PEGylated liposome-mediated complement activation and anaphylatoxin production, FASEB /., 20, 2591-2593. 

Cohen, O., Kronman, C., Raveh, L., Mazor, O., Ordentlich, A, Shafferman, A. (2006). Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human bufyrylcholinesterase as bioscavengers of organophosphate compounds. Mol. Pharmacol. 70 1121-31. 

Mossman BT, Marsh JP, Sesko A, et al. 1990b. Inhibition of lung injury, inflammation, and interstitial pulmonary fibrosis by polyethylene glycol-conjugated catalase in a rapid inhalation model of asbestosis. Am Rev RespirDis 141 1266-1271. 

Zalipsky S. Adv. Chemistry of polyethylene-glycol conjugates with biologically-active molecules. Adv. Drug Deliv. Rev. 1995 16 157-182. 

Tang G, et al. Polyethylene glycol-conjugated superoxide dismutase projects rats against oxygen toxicity. J Appl Physiol 74(3) 1425-1431, 1993. 

Bax BE, Bain MD, Fairbank LD, et al. In vitro and in vivo studies with human carrier erythrocytes loaded with polyethylene glycol-conjugated and native adenosine deaminase. Br J Haematol 2000 109 549-554. 

E. G. McEwen, R. C. Rosenthal, L. E. Fox, et al. Evaluation of 1-asparaginase polyethylene glycol conjugate versus native 1-asparaginase combined with chemotherapy. J. Vet. Intern. Med. 6 230 (1992). 

Bailon, P., Berthold, W., Polyethylene glycol-conjugated pharmaceutical proteins, Pharmac. Sci. Technol. Today 1, 352-356, 1998. 

Polyethylene Glycol Conjugation of Protein and Small Molecule Drugs... 

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