Acute brain injury

The use of DA-ergic forms of medication in other forms of neurological disturbance is not well developed, but case study reports and experimental findings suggest possible 

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Meixensberger J, Baunach S, Amschler J, Dings J, Roosen K. Influence of body position on tissue-po2> cerebral perfusion pressure and intracranial pressure in patients with acute brain injury. Neurol Res 1997 19(3) 249-253. 

Stocchetti N, Protti A, Lattuada M, Magnoni S, Longhi L, Ghisoni L, Egidi M, Zanier ER. Impact of pyrexia on neurochemistry and cerebral oxygenation after acute brain injury. J Neurol Neurosurg Psych 2005 76(8) 1135-1139. 

Landolt H, Langemann H. 1996. Cerebral microdialysis as a diagnostic tool in acute brain injury. Eur Anaesthesiol 13... 

Discrepancies between results from the preliminary studies and the larger, multicenter trials remain to be elucidated. Significant intercenter variance in patient management (fluids, mean arterial blood pressure, ICP, and CPP) and treatment may have adversely affected the results of one of these trials (The National Acute Brain Injury Study Hypothermia) (61). Despite the overall negative findings, however, it is quite possible that certain subgroups of patients may benefit from treatment with mild hypothermia. 

Clifton G. L., Choi S. C., Miller E. R., et al. (2001) Intercenter variance in clinical trials of head trauma—experience of the National Acute Brain Injury Study Hypothermia. J. Neurosurg. 95,751-755. 

Clifton G. L. (2000) Hypothermia in acute brain injury. Neurosci. Res. Center News 7,1-2. 

Restorations of underactive (or alternatively, reductions in overactive) DA transmission are generally assumed to be beneficial for cognitive function, motivating attempts to treat diverse disorders such as Parkinson s disease, schizophrenia, ADHD and most recently, acute brain injury. 

Wada A, Yokoo H, Yanagita T, Kobayashi H. Lithium potential therapeutics against acute brain injuries and chronic neurodegenerative diseases. J Pharmacol Sci 2005 99(4) 307-21. 

TABLE 56—1. Clinical Presentation of Acute Brain Injury... 

Clifton GL, Miller ER, Choi SC, et al. Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med 2001 344 556-563. 

Amankulor NM, Hambardzumyan D, Pyonteck SM, Becher OJ, Joyce JA, Holland EC (2009) Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation. J Neurosd 29 10299-10308... 

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