Biotechnological process

Biotechnological processes may be divided into fermentation processes and biotransformations. In a fermentation process, products are formed from components in the fermentation broth, as primary or secondary metabolites, by microorganisms or higher cells. Product examples are amino acids, vitamins, or antibiotics such as penicillin or cephalosporin. In these cases, co-solvents are sometimes used for in situ product extraction. 

Biotechnological processes verses chemical synthetic processes 21... 

The identified enzymes need to be characterized on a more detailed level before application in biotechnological processes. 

Enhanced thermal stability enlarges the areas of application of protein films. In particular it might be possible to improve the yield of reactors in biotechnological processes based on enzymatic catalysis, by increasing the temperature of the reaction and using enzymes deposited by the LB technique. Nevertheless, a major technical difficulty is that enzyme films must be deposited on suitable supports, such as small spheres, in order to increase the number of enzyme molecules involved in the process, thus providing a better performance of the reactor. An increased surface-to-volume ratio in the case of spheres will increase the number of enzyme molecules in a fixed reactor volume. Moreover, since the major part of known enzymatic reactions is carried out in liquid phase, protein molecules must be attached chemically to the sphere surface in order to prevent their detachment during operation. 

L. E. S. Brink and J. Tramper, in Modelling and Control of Biotechnological Processes, Pergammon Press, Oxford, 1985, pp. 111-117. 

E Ruckenstein, V Lesins. Classification of liquid chromatographic methods based on the interaction forces The niche of potential barrier chromatography. In A Mizrahi, ed. Advances in Biotechnological Processes, Vol 8 Downstream Processes Equipment and Techniques. New York Alan R. Liss, 1988, pp 241-314. 

Shell" and Biotechnology. Xanthan is manufactured by fermentation, a biotechnological process. How could "Shell", an oil company, be interested in such processes The Royal Dutch/Shell Group is, however, no newcomer to biotechnology. The Milstead Laboratory of Chemical Enzymology was set up in 1962 and was headed by Professor John Cornforth, who went on to win the 1975 Nobel prize for Chemistry shortly after he retired. In 1970 a fermentation laboratory was built on the same site. 

Iwatani, S., Yamada, Y. andUsuda, Y. (2008) Metabolic flux analysis in biotechnology processes. Biotechnology Letters, 30, 791-799. 

Inada, Y., Takahashi, K., Yoshimoto, T., Ajima, A., Matsushima, A., and Saito, Y. (1986) Applications of polyethylene glycol-modified enzymes in biotechnological processes Organic solvent-soluble enzymes. Trends Biotechnol. 4, 190-194. 

In this chapter we describe the use of pea seeds to express the bacterial enzyme a-amylase. Bacterial exoenzymes like the heat stable a-amylase from Bacillus licheni-formis are important for starch hydrolysis in the food industry. The enzymatic properties of a-amylase are well understood [13,14], it is one of the most thermostable enzymes in nature and it is the most commonly used enzyme in biotechnological processes. Although fermentation in bacteria allows highly efficient enzyme production, plant-based synthesis allows in situ enzymatic activity to degrade endogenous reserve starch, as shown in experiments with non-crop plants performed under greenhouse conditions [12,15]. Finally, the quantitative and sensitive detection of a-amylase activ-... 

The above definition of classical biotechnological processes can easily be adapted to the concept of molecular farming. With plant cell fermentation the analogy is ob-... 

Biotechnological processes, life-cycle assessments for, 24 183 Biotechnology, 3 816 advances in, 13 330 application to agriculture, 13 283 in chemical transformations,... 

When the drug is a peptide produced by a biotechnology process. 

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