Biotechnological processing, applied Biotechnology

Setti, L. Farinelli, P. Di Martino, S., et al., Developments in Destructive and Non-Destructive Pathways for Selective Desulfurizations in Oil-Biorefining Processes. Applied Microbiology and Biotechnology, 1999. 52(1) pp. 111-117. 

Gomez J., R. Mendez, and J.M. Lemna (1996). The effect of antibiotics on nitrification processes. Applied Biochemistry and Biotechnology 57/58 869-876. 

S. Elnashaie, G. Ibrahim, Heterogeneous Modeling for the Alcoholic Fermentation Process, Applied Biochemistry and Biotechnology, 19(1), 71-101, 1988... 

Lunelli, B. H., Duarte, E. R., Vasco de Toledo, E. C., Wolf Maciel, M. R., Maciel Filho, R. (2007). A new process for acrylic acid synthesis by fermentative process. Applied Biochemistry and Biotechnology, 136-140, 487-500. 

K. Lee, D.K. Newman. Microbial iron respiration Impacts on corrosion processes. Applied Microbiology Biotechnology, Vol. 62, pp. 134—139, 2003. 

Schmidt FR. Optimization and scale up of industrial fermentation processes. Applied Microbiology and Biotechnology 2005 68 425-435. 

Hatzis, C. Riley, C. Hiilippidis, G.P. Detailed Material Balance and Edumol Yield Calculations for die Biomass-to-Elfaanol Conversion Process Applied Biochemistry and Biotechnology. Proceedings of die 17 Symposium on Biotechnolo fmr Fuels and Chemicals, SfNing 1996, 57-58, pp. 443-459. 

Chatzifragkou, A., Papanikolaou, S., 2012. Effect of impurities in biodiesel-derived waste glycerol on the performance and feasibility of biotechnological processes. Applied Microbiology and Biotechnology 95, 13—27. 

Chi, Z., Zheng, Y., Jiang, A., Chen, S., 2011. Lipid production by culturing oleaginous yeast and algae with food waste and municipal wastewater in an integrated process. Applied Biochemistry and Biotechnology 165 (2), 442—453. 

Jacobsen, S Ji., Wyman, C.E., 1999. Hemicellulose and cellulose hydrolysis models for application to current and novel pretreatinent processes. Applied Biochemistry and Biotechnology 84—86, 81—96. 

Recent advances in biotechnology have resulted in improved fermentation processes for the production of useful chemical intermediates. One such process was developed a few years ago during the U.S. DOE sponsored CRADA (Cooperative Research and Development Agreement) with Applied Carbochemicals (ACC). Under this CRADA a consortium of four national labs including Argonne National Laboratory (ANL), Oak Ridge National Laboratory (ORNL), National Renewable Energy Laboratory (NREL), and Pacific... 

Goldberg, K., Schroer, K., Luetz, S. and Liese, A. (2007) Biocatalytic ketone reduction - a powerful tool for the production of chiral alcohols -part I processes with isolated enzymes. Applied Microbiology and Biotechnology, 76, 237-248. 

Shokri, A., Sanden, A.M. and Larsson, G. (2003) Cell and process design for targeting of recombinant protein into the culture medium of Pichia pastoris. Applied Microbiology and Biotechnology, 60 (6), 654-664. 

Enchira Biotechnology, EBC, which was headquartered near Houston, TX, used to be the largest biotechnological platform devoted to the development of biorefining processes. EBC acquired Energy Biosystems in June 2000 and continued the R D activities on BDS during the last years. This company applied directed evolution methods to accelerate development and commercialization of gene-based products for the industrial... 

Although, MediChem is a biosecurity products manufacturer, its biotechnology-based R D capabilities are worth mentioning here. The attended markets include Medical, Laboratory, Veterinary, and Environmental sectors. Medicinal chemistry services and drug discovery form the basis of the company, though their capabilities might be applied in a broader range of sectors. These capabilities comprise the areas of Proteomics, Combinatorial and Computational Chemistry, Medicinal Chemistry, Enzymes, Process Development, Analytical and Separations Chemistry, Chemical Synthesis and Scale Up. 

The Marine Biotechnology Institute (MBI) was founded in 1987 for the study and applications of biodiversity in marine environments. Currently, and within the scope of the present book, the research area of relevance is industrial applications of microbiology . The institute also performs research in C02 fixation. The Applied Microbiology Laboratory is searching cost-effective utilization of microbes for environmental conservation and restoration. In particular, the decontamination of areas polluted with petroleum-related compounds has been addressed. Attention has been paid to removal of polycyclic hydrocarbons. They are also developing processing methods for the conversion of biomass and organic wastes by methane fermentation. 

The 1980 s and the early 1990 s have seen the blossoming development of the biotechnology field. Three-phase fluidized bed bioreactors have become an essential element in the commercialization of processes to yield products and treat wastewater via biological mechanisms. Fluidized bed bioreactors have been applied in the areas of wastewater treatment, discussed previously, fermentation, and cell culture. The large scale application of three-phase fluidized bed or slurry bubble column fermen-tors are represented by ethanol production in a 10,000 liter fermentor (Samejima et al., 1984), penicillin production in a 200 liter fermentor (Endo et al., 1986), and the production of monoclonal antibodies in a 1,000 liter slurry bubble column bioreactor (Birch et al., 1985). Fan (1989) provides a complete review of biological applications of three-phase fluidized beds up to 1989. Part II of this chapter covers the recent developments in three-phase fluidized bed bioreactor technology. 

---