Biomimetic calcium phosphate coatings

Biomimetic Calcium Phosphate Coatings Deposited on Various Substrates... 

Barnes, D.H., Cameron, R.E., Klamil, S., Meyer, F., Brooks, R.A., Rushton, N., and Best, S.M. (2011) Biomimetic calcium phosphate coatings by polymeric artificial spinal disc implants. Bioceram. Dev. Appl., 1, Article ID D101111, 4 pp. 

Barrere, F. (2002) Biomimetic calcium phosphate coatings. Physicochemistry and biological activity. PhD dissertation. University of Twente. 

Barrere, F., Layrolle, P., van Blitterswijk, C.A., and de Groot, K. (1999) Biomimetic calcium phosphate coatings on Ti6A14V a crystal growth study of octacalcium phosphate and inhibition by Mg2+ and HC03-. Bone, 25, 107S-111S. 

Control of surface topography in biomimetic calcium phosphate coatings. Langmuir, 28 (8), 3871-3880. 

L. C., and Oliveira, M.V. (2014) Dense and porous titanium substrates with a biomimetic calcium phosphate coating. Appl. Surf. Sci., 265, 250-256. 

C. (2003) Biological performance of biomimetic calcium phosphate coating of titanium implants in the dog mandible. /. Biomed. Mater. Res. A, 64 (2), 225-234. 

Yang, F. Wolke, J.G.C. Jansen, J.A. Biomimetic calcium phosphate coating on electrospun poly (epsi-lon-caprolactone) scaffolds for bone tissue engineering. Chem. Eng. J. 2008,137 (1), 154-161. 

Leeuwenbuigh S, Layrolle P, Barrere F, de Braijn J, Schoomnan J, van Blitterswijk CA, et al. Osteoclastic resorption of biomimetic calcium phosphate coatings in vitro. J Biomed Mater Res 2001 56 208-15. 

Proteins such as rhBMP can be incorporated into calcium phosphate layers when biomimetically co-precipitated with the inorganic components (Liu et al., 2004). For example, rhBMP-2 (0.1-10pgml-1) retains its osseoinductive potential when incorporated into the crystal lattice of hydroxyapatite in a dose-dependent manner as ascertained by protein blot staining and enzyme-linked immunosorbent assay (ELISA). The positive osseogenicity of rhBMP-2 was assessed quantitatively by monitoring ALP activity (see Section 7.10.3.1) on rat BMSCs grown directly on the calcium phosphate coatings. 

Liu, Y., Hunziker, E.B., Randall, N.X., de Groot, I<., and Layrolle, P. (2003) Proteins incorporated into biomimetically prepared calcium phosphate coatings modulate their mechanical strength and dissolution rate. Biomaterials, 24 (1), 65-70. 

Drelich, J. and Field, K.G. (2007) Formation of biomimetic porous calcium phosphate coatings on surfaces of polyethylene/zinc stearate blends. Materials Science and Technology (MS T), September 16-20, 2007, Detroit, MI, p. 187. 

The ability of biomimetically deposited calcium phosphate coatings to foster peri-implant bone formation was tested and positively answered by many studies involving a dog model (for example Schliephake et al., 2003 Schliephake et al., 2006 Schliephake et al., 2009 Coelho et al., 2009). 

Schliephake, H., Scharnweber, D., Roesseler, S., Dard, M., Sewing, A., and Aref, A. (2006) Biomimetic calcium phosphate composite coating of dental implants. 

Costa, N. and Maquis, P. M. 1998. Biomimetic processing of calcium phosphate coating, Med Eng Physio, 601-606. 

A. Pasinli, M. Yuksel, E. Celik, S. Sener, and A. C. Tas, A New Approach in Biomimetic Synthesis of Calcium Phosphate Coatings using Lactic acid-Na Lactate buffered Body Fiuid Soiution, Acta Biomater., 6, 2282-8 (2010). 

Araujo et al. (2008) prepared PCL electrospun nanofiber meshes coated with a biomimetic calcium phosphate (BCP) layer that mimics the extracellular microenvironment found in the human bone structure. The deposition of a calcium phosphate layer, similar to the inorganic phase of bone, on the PCL nanofiber meshes was... 

Chen, C., Lee, I.-S., Zhang, S.-M., Yang, H.C., 2010. Biomimetic apatite formation on calcium phosphate-coated titanium in Dulbecco s phosphate-buffered saline solution containing CaCl2 with and without fibronectin. Acta Biomater. 6, 2274—2281. http //dx.doi.org/ 10.1016/j.actbio.2009.11.033. 

Varma H.K., Yokogawa Y., Espinosa F.F., Kawamoto Y., Nishizawa K., Nagata F., Kameyama T. Porous calcium phosphate coating over phosphorylated chitosan film by a biomimetic method. Biomaterials 1999 20 879-884... 

Mavis B, Demirta TT, Gtimiigderelioglu M, Giindiiz G, olak U. Synthesis, characterization and osteoblastic activity of polycaprolactone nanofibers coated with biomimetic calcium phosphate. Acta Biomater 2009 5(8) 3098-lll. 

Li X et al (2008) Coating electrospun poly(epsilon-caprolactone) fibers with gelatin and calcium phosphate and their use as biomimetic scaffolds for bone tissue engineering. Langmuir 24(24) 14145-14150... 

Biomimetic coating of cholesterol with hydroxyapatite is characterised by an epitaxial relationship between cholesterol monohydrate recrystallised from polar solvents and hydroxyapatite, and thus enhances deposition rate. However, chemical modification of cholesterol, for example by phosphorylation destroys the epitaxy and hence this material fails to act as a viable template for calcium phosphate deposition (Laird, Mucalo and Yokogawa, 2006). This research may... 

It might be argued that the results by Jager et al. (2006) discussed and interpreted earlier pertain only to nanocrystalline hydroxyapatite synthesised from an aqueous solution. However, they are clearly relevant to calcium phosphate biomimetically precipitated from SBFs used to validate the degree of osseoconductivity of bioceramic coatings. 

PARK are frequently used without surface modification. There are a significant number of papers and patents which describe PEEK modified with fillers such as hydroxyapatite (HA) or calcium phosphates, titanimn coatings or even biomimetic protein and peptide sequences. Some of these are described in reference [2]. However, in HA-filled PARK there is a trade-off between mechanical properties and modified biocompatibility. Various attempts have been made to overcome this limitation - for example by using HA coatings or HA whiskers [3, 4]. Biological modifications would be subject to extremely complex regulatory approval. In fact unmodified PEEK has been shown to be comparable in vitro with the bone forming capacity of titanium [5]. 

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