Biologies stability considerations

Biological considerations Orally, serves as energy source (and therefore can alter food consumption and/or body weight). Prolonged oral administration has been associated with enhanced carcinogenesis Chemical compatibility/Stability considerations Thickens upon prolonged exposure to air... [Pg.494]

Solubility/miscibility Insoluble in ethanol. Soluble to twice its weight (2 x grams) in water (xml). Soluble in glycerol and propylene glycol Biological considerations Virtually biologically inert Chemical compatibility/Stability considerations None Uses (routes) Orally, as diluent or viscosity increaser in solvents... [Pg.496]

Solubility/miscibility One gram soluble in 5 ml water slightly soluble in alcohol Biological considerations White powder. Energy source Chemical compatibility/Stability considerations None... [Pg.496]

Biological considerations Oral LD50 (rats) = 6.86 ml kg. Repeated dermal use can lead to defatting of skin. CNS depressant by inhalation Chemical compatibility/Stability considerations Flammable, colorless liquid Uses (routes) Dermal... [Pg.497]

Solubility/miscibility Insoluble in water and ethanol. Soluble in ether and oils Biological considerations Aspiration may cause lipoid pneumonia Chemical compatibility/Stability considerations Flammable Uses (routes) Oral, vaginal, rectal, dermal. Suspending agent... [Pg.497]

Solubility/miscibility Slightly soluble in ethanol miscible with ether Biological considerations Can serve as an energy source Chemical compatibility/Stability considerations Pale yellow or light greenish-yellow oil. Becomes rancid upon exposure to air Uses (routes) Oral... [Pg.498]

Solubility/miscibility Miscible with ether and other oils. Slightly soluble in ethanol slightly soluble in ether Biological considerations Orally, serves as an energy source Chemical compatibility/Stability considerations Clouds at room temperatures. [Pg.498]

Solubility/miscibility Miscible with MEK, ethanol, acetone Biological considerations No limitations except high volumes via the IV route can disturb systemic electrolyte balance and cause hemolysis and hematuria Chemical compatibility/Stability considerations None Uses (routes) All. The vehicle and solvent of first choice... [Pg.500]

Gislason M K et al. (2010) Finite element model creation and stability considerations of complex biological articulation The human wrist joint, Med Eng Phys 32 523-31... [Pg.777]

Practical considerations for the polymer solution are that (1) it must be injectable into the reservoir, (2) it must survive, and (3) it must be able to move through the reservoir and provide the required viscosity. Field tests were done to verify injectivity, biological stability, and in-situ viscosity. Falloff tests, done after injection at variable rates, were conducted to investigate the non-Newtonian behavior of the polymer bank in the reservoir. Falloff test results and in-situ viscosity estimates were given previously. A three-dimensional reservoir simulation, not covered in this paper, used field-generated data to project an oil production schedule for the final economic analysis. [Pg.231]

An understanding of a wide variety of phenomena concerning conformational stabilities and molecule-molecule association (protein-protein, protein-ligand, and protein-nucleic acid) requires consideration of solvation effects. In particular, a quantitative assessment of the relative contribution of hydrophobic and electrostatic interactions in macromolecular recognition is a problem of central importance in biology. [Pg.133]

An elastomeric closure is a packaging component that is, or may be, in direct contact with a drug product. Elastomer selection for parenteral packaging principally involves consideration of chemical, physical, and biological properties, with emphasis on the stability profile of the drug/container system. Typical elastomeric closure compositions are listed in Tables 1 1. Although certain packaging applications frequently call to mind certain elastomer types, it is not feasible to prescribe specific... [Pg.589]

A major consideration before the ligand exchange equilibria can be considered with reference to biological systems is the stability of a particular oxidation state in the biological medium. Low-spin complexes undergo rapid one-electron oxidation and reduction. As a biological system operates at a low redox potential, say —0.5 to 0.0 volts, reduced, i.e. low valence, states of the metals are to be expected. The metal complexes, Ru, Os, Rh, Ir, Pd, Pt and Au should be reduced to the metallic state in fact but for the slow speed of this reduction. The metals of Fig. 6 will tend to go to the following redox states ... [Pg.16]