Why Protein and Peptide Encapsulation

There are two main problems in obtaining polymeric micro- and nanoparticles, and these issues represent an obstacle when you want to scale up a product of its kind to be offered in the market. 

Size and size distribution of the particles are difficult to control, resulting in poor reproducibility in large-scale production for this reason the drug delivery system may fail to be approved. 

It is also difficult to maintain the bioactivity of protein/peptide drugs during the preparation, storage, and release of the drug. If these biological actives suffer deactivation the therapeutic effect no longer exists [8-11]. 

To solve these problems encapsulation techniques have been developed [12,13]. Micro- or nanoencapsulation can envelop protein/peptide drugs within a polymeric matrix in order to protect them from degradation and modulate the biological active release [14]. 

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