Drug Particle Size

Johnson, K., Swindell, A. Guidance in the setting of drug particle size specifications to minimize variability in absorption. Pharm. Res. 1996, 13, 1795-1798. 

R Evans. Determination of drug particle size and morphology using optical microscopy. Pharm Technol... 

E. K. Anderberg, M. Bisrat, C. Nystrom. Physicochemical aspects of drug release. VII. The effect of surfactant concentration and drug particle size on solubility and dissolution rate of felodipine, a sparingly soluble drug. Int. I. Pharm. 1988, 47, 67-77. 

Drug particle size can also be a factor in mixing uniformity. When particles of different sizes are mixed, the smaller particles tend to travel or percolate downward. This tendency is a particular problem with low-dose drugs, where a small amount of drug is to be mixed with large amounts of diluents. In this situation, it is more difficult to achieve uniform mixing, and undesirable... 

Anderberg, E.K., Bisrat, M., and Nystrom, C. (1988), Physicochemical Aspects of Drug Release. VII. The Effect of Surfactant Concentration and Drug Particle Size on Solubility and Dissolution Rate of Felodipine, a Sparingly Soluble Drug, Intemat. J. of Pharma., 47, 67-77. 

Liversidge, G G. and Conzentino, P. (1995) Drug particle size reduction for decreasing gastric irritancy and enhancing absorption of naproxen in rite, J. Pharm., 125(2) 309-313. 

The drug particle size is also an important parameter [19]. Scholz et al. [20] studied the influence of drug particle size on felodipine absorption in dogs. Micronized (8 pm) or coarse (125 pm) suspensions of felodipine were orally administered to dogs, and absorption parameters were studied. The reduction in particle size led to a 22-fold increase in Cmax and to a... 

Zhang Y, Johnson KC. 1997. Effect of drug particle size on content uniformity of low-dose solid dosage forms. Int. J. Pharm. 154 179-183. 

The goal of this chapter is to describe the effect of drug particle size on content uniformity using the concept of ideal mixing.1 The intention is to provide a... 

Figure 3.2 Drug particle size mass and number distribution normalized to a unit dose of 0.1 mg. Square symbols represent the mass distribution (left axis) and circular symbols represent the number distribution (right axis). The same data are also shown in Table 3.1.

TABLE 3.1 Drug Particle Size Mass and Number Distribution for a 0.1 mg Dose... 

TABLE 3.2 Potency Distribution for a 0.1 mg Dose Simulated for 100,000 Unit Doses Using the Ideal Mixing Model and the Drug Particle Size Distribution in Fig. 3.2 and Table 3.1... 

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