Suspensions injectable

Parenteral suspensions (injection) Exact dose 100% compliance Suitable for unconscious patient Rapid onset, especially after intravenous administration Painful Self-administration vmusual Requires trained personnel Solutions, emulsions, implants Expensive production processes... 

Fill one syringe with 0.1 ml cell suspension, inject, place empty syringe on ice, remix cell suspension, and fill a second syringe for injection. Alternate syringes to keep them cold and avoid having the Matrigel solidify inside. 

Skeletal muscle cells are capable of regeneration and repair more readily than cardiac myocytes owing to the so-called satellite cells that can be readily mobilized at the time of injury (16). They are capable of easy expansion in culture can be harvested easily from the autologous host and are fairly resistant to hypoxia (17). The major drawback is that as the skeletal myocytes mature, they no longer form gap junctions and become electrically isolated, predisposing to re-entry arrhythmias (18). In addition, despite some encouraging data (19), the viability of dissociated myoblasts in suspension injected into myocardial scar deprived of appropriate trophic environment has been called into question (20), In our hands, skeletal myoblasts injected into canine myocardium could not be identified four weeks after implantation, and the needle tract caused fibrosis and scarring (Fig. 2). 

The aim of the experiments was to obtain stationary values for SO2 separation. Initially, the hold-up was sprayed with water to obtain stationary temperatures after cooling the particles and to conserve the used calcium hydroxide during the unsteady start-up phase. At the steady-state temperature the injection was suddenly switched to suspension. The SC>2-concentration at the outlet then decreased. The suspension consisted of lime hydrate (DIN 1060-CL90, DIN EN 12518) and water. The suspension injection had to be held constant until the SC>2-concentration was constant. After achieving steady state the injection was stopped, and this caused an increase in SC>2-concentration at the outlet up to the initial value. The same procedure was started after a few minutes in order to obtain a new measuring point at a higher suspension injection rate. 

Any increase of the suspension injection, in order to realize an improved separation of the gas component which can be removed, is not possible. The maximum liquid and/or solvent injection into a fluidized bed is limited by the capacity of the fluidization gas. The maximum of the capacity is reached with the state of saturation of the gas. Figure 16.6 illustrates the dependence of the adjusting wetted surface and the absolute humidity on the spraying liquid mass flow. Clearly, a small deviation of... 

With the same method also tubes consisting of a CR-1 outside layer and an AKP-30 inside layer were prepared. The CR-1 suspension was produced in essentially the same way as described above for the AKP-30 suspension. Injection also took place in the same way as the single powder AKP-30 tube. The process started with injecting the CR-1 suspension and afterwards the AKP-30 suspension was injected. An SEM photograph of the resulting tube is shown in Figure 6. 

Even if the same drug substance HPLC method is used for the drug product, forced decomposition studies must be performed again for the drug product to confirm the resolution of potential degradation products from the API. In addition, forced decomposition studies must also be performed for different dosage forms (capsule, tablet, suspension, injectable, etc.) of the same drug substance. 

Sterile suspensions (injectable and ophthalmic) have characteristics that are not commonly shared by other suspension systems, such as ease of resuspension, drainage, absence of foreign particulate matter and pyrogens, and syringeability in the case of injectable suspensions. 

Superfloe 900 3059 Suspension injectable d insuline protamine zinc 2042... 

Dosage forms available capsules, oral and chewable tablets, suspension, injection... 

Steroids are usually found in three dosage forms (1) tablets and capsules, (2) aqueous suspensions (injectables), and (3) oil solutions (injectables). A variety of oils, vitamins, plant sterols, and plant extracts have been found in exhibits suspected of containing anabolic steroids. In addition, fillers and/or caffeine have been substituted in tablets. Mixtures of anabolic steroids are also found in some samples, none of which may be the steroid(s) listed on the label. For these reasons sample preparation of the steroid products is made somewhat complex because of the various ways in which these samples are found. Sometimes it may be necessary to refrigerate the sample first to allow the oil phase and aqueous phase to separate, subsequently providing a cleaner and more efficient extraction. An analytical method consisting of extraction, TLC, UV spectra, and GCMS was devised for 13 commonly abused anabolic steroids (57). This extraction is outlined in Table 16.7. 

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