Poly microspheres biodegradable

Waeckerle-Men Y, Allmen EU, Gander B et al (2006) Encapsulation of proteins and peptides into biodegradable poly(D, L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells. Vaccine 24 1847-1857... 

To provide for prolonged, site-specific delivery of NGF to the tissue in a convenient manner without affecting the properties of the conduit, biodegradable polymer microspheres of poly(L-lactide)co-glycolide... 

The effect of NaOH on drug release was examined with microspheres prepared with thioridazine and two biodegradable polymers. The wall-forming polymers were poly(DL-lactide) and poly(L-lactide). Sodium oleate was used as the emulsifier, with the exception of one set of experiments where the emulsions were stabilized with polyvinyl alcohol. 

Work in this field has concentrated on the use of poly(lactide-co-glycolide) microparticles, which have the advantages of being biocompatible, biodegradable and well tolerated in humans. Promising results have also been obtained with the use of biodegradable starch microspheres in conjunction with the absorption enhancer lysophosphatidylcholine. 

Cho, S. W., Song, S. H., and Choi, Y. W. (2000), Effects of solvent selection and fabrication on the characteristics of biodegradable poly(lactide-co-glycolide) microspheres containing ovalbumin, Arch. Pharm. Res., 23, 385-390. 

Bittner, B., Witt, C., Mader, K., and Kissel, T. (1999), Degradation and protein release properties of microspheres prepared from biodegradable poly(lactide-co-glycolide) and ABA triblock copolymers Influence of buffer media on polymer erosion and bovine serum albumin release, J. Controlled Release, 60, 297-309. 

Jung, T., Koneberg, R., Flungerer, K. D., and Kissel, T. (2002), Tetanus toxoid microspheres consisting of biodegradable poly(lactide-co-glycolide)- and ABA-triblock-copolymers Immune response in mice, Int. J. Pharm., 234, 75-90. 

Li, J. K., Wang, N., and Wu, X. S. (1997), A novel biodegradable system based on gelatin nanoparticles and poly (lactic-co-glycolic acid) microspheres for protein and peptide drug delivery, J. Pharm. Sci., 86(8), 891-895. 

Fatty acids are used in preparation of microspheres for controlled drug delivery. For example, poly(vinyl alcohol), substituted with lauric, myristic, palmitic, and stearic acids at different substitution degrees was employed for the preparation biodegradable microspheres containing progesterone or indo-... 

Crotts, G. Park, T.G. Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres release kinetics and stability issues. J. of Microencap. 1998,15 (6), 699-713. 

Jain, R.A. Rhodes, C.T. Railkar, A.M. Mahck, A.W. Shah, N.H. Comparison of various injectable protein-loaded biodegradable poly(lactide-co-glycolide) (PGLA) devices in-Situ formed implant versus in-Situ formed microspheres. Pharm. Devel. Technol. 2000, 5, 201-227. 

Kempen Diederik, H.R. Lu, L. Zhu, X. Kim, C. Jabbari, E. Dhert Wouter, J.A. Currier Bradford, L. Yaszemski Michael, J. Development of biodegradable poly(propylene fumarate)/poly(lactic-co-glycolic acid) blend microspheres. II. Controlled drug release and microsphere degradation. J. Biomed. Mater. Res. 2004, 70A (2), 293-302. 

For drugs which are soluble in SC CO2, the SC fluid can be expanded info air, or info a solufion containing polymers and other additives, such as phospholipids or Tween 80.1 By varying depressurization, the product can be formed as very fine particles, fibers, thin films, or as biodegradable polymeric microspheres containing drug. Typical biodegradable polymers which are soluble in the SC fluid include poly(hydroxyacid) and poly(D,L-lactic acid). Scale-up has been complicated... 

A variety of methods have been used for microsphere formation including non-degradable polystyrene, poly(methyl methacrylate) (PMMA), and polyacrylamide (PAAm) microspheres, as well as PLLA, PGA, PGLA, polycyanoacrylate, starch, and protein microspheres, which would be more likely to be fully biodegradable [42, 110]. Measurable amounts of polystyrene [107] and PAAm microspheres [110] persist in the tissue for many weeks after administration. It seems likely, however, that PGA [108] and protein microspheres [110] may be degraded in vivo in a period of days. 

In topical formulations, particularly cosmetics, it is used for its softening and conditioning effect on the skin. Lactic acid may also be used in the production of biodegradable polymers and microspheres, such as poly(D-lactic acid), used in drug delivery systems.See also Aliphatic Polyesters. 

The properties of nanoparticles depend on surface morphology, specific surface area, particle size distribution, bulk density, drug incorporation, capacity, release, hydrophobicity, bioadhesiveness, and biodegradability. Nanoparticles (microspheres) loaded with the drug product can be formulated using copolymers, e.g., poly(lactide-co-glycolide) (PLG) or poly(lactide-co-ethylphosphate), by solvent extraction/evaporation technique. 

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