Beta-hydroxybutyrate

Comeau et al. [46] have described a simple assay for separating and quantifying poly-beta-hydroxybutyrate and poly-beta-hydroxyvalerate in activated sludge samples involved sludge lyophilization, purification of the chloroform extract by re-extraction with water, and capillary gas liquid chromatography. The detection limit, estimated by using hydroxybutyric acid standards, was approximately lOug per litre. [Pg.154]

Artuch R, Vilaseca MA, Farre C, Ramon F (1995) Determination of lactate, pyruvate, beta-hydroxybutyrate and acetoacetate with a centrifugal analyser. Eur J Clin Chem Clin Biochem 33 529-533... [Pg.53]

Li PK, Lee JT, Mac Gillivray MH, Schaefer PA, Siegel JH (1980) Direct, fixed-time kinetic assays for beta-hydroxybutyrate and acetoacetate with a centrifugal analyser or a computer-backed spectrophotometer. Clin Chem 26 1713-1717... [Pg.53]

G. N. Rees, G. Vasiliadis, J. W. May and R. C. Bayly (1992). Differentiation of polyphosphate and poly-beta-hydroxybutyrate granules in an Acinetobacter sp. isolated from activated sludge. FEMS Microbiol. Lett., 73, 171-173. [Pg.251]

Laarveld B., Chaplin, R.K. and Brockman, R.P. 1985. Effects of insulin on the metabolism of acetate, beta-hydroxybutyrate and triglycerides by the bovine mammary gland. Comp. Biochem. Physiol. B. 82, 265-267. [Pg.86]

Serum levels of ketones, as measured by beta-hydroxybutyrate, and free fatty acids tended to be greater following DAG oil consumption with serum ketone levels being significantly greater on day 2 (at first draw) after DAG oil consumption p < 0.05 vs. TAG oil using post-hoc analysis). Serum ketone levels after DAG oil consumption remained substantially below the level of serum ketones observed in ketogenic diets. [Pg.1407]

The energy provided to the peripheral tissues from acetoacetate and for beta-hydroxybutyrate are shown below (Table 10.1)... [Pg.356]

Like other sulfhydryl-containing compounds, captopril can cause false-positive ketonuria when assessed with the Legal reaction (sodium nitroprusside reacting with acetoacetic acid and possibly with acetone). It has therefore been suggested that in patients with diabetes taking such drugs ketonuria should be assessed with the Acetest (20). Alternatively, a blood ketone test with Acetest and/ or enzymatic detection of beta-hydroxybutyric acid can be performed for confirmation. [Pg.627]

Butyric acid is rapidly metabolized in the liver to acetic acid and ketone bodies (acetone, acetoacetate, beta-hydroxybutyrate). In humans, the butyric acid elimination curve can be divided into two parts corresponding to two half-lives for the first (0.5 min), the slope suggests an accelerated excretion for the second (13.7min), a slow plateau is observed. [Pg.369]

Porter WH, Yao HH, Karounos DG. Laboratory and clinical evaluation of assays for beta-hydroxybutyrate. Am J Clin Pathol 1997 107 353-8. [Pg.898]

Umpierrez GE, Watts NB, Phillips LS. Clinical utility of beta-hydroxybutyrate determined by reflectance meter in the management of diabetic ketoacidosis. Diabetes Care 1995 18 137-8,... [Pg.900]

Khardenavis, A. A., Kumar, M. S., Mudliar, S. N., and Chakrabarti, T. (2007). Biotechnological conversion of agro-industrial wastewaters into biodegradable plastic, poly-beta-hydroxybutyrate. Bioresour. Technol. 18, 3579-3584. [Pg.128]

Harrison, M.P Jones, D.V. Pickford, R.J. Wilson, I.D. Beta-Hydroxybutyrate A Urinary Marker of Imipenem Induced Nephrotoxicity in theCynomolgus Monkey Detected by High Field NMR Spectroscopy, Biochem. Pharmacol. 41(12), 2045-2049 (1991). [Pg.148]

Dahlquist G, Persson U, Persson B. The activity of D-beta-hydroxybutyrate dehydrogenase in fetal, infant and adult rat brain and the influence of starvation. Biol Neonate 1972 20 40-50. [Pg.287]

Freeman JM, Vining EPG, Pyzik PL, Gilbert DL. Beta-hydroxybutyrate levels in blood correlate with seizure... [Pg.287]

Ge S, Niesen CE. Beta-hydroxybutyrate potentiates GABA-A mediated inhibitory postsynaptic potentials in immature hippocampal CAl neurons. Epilepsia 1998 39 (Suppl 61 135. [Pg.288]

Niesen CE. Ge 8. The effect of ketone bodies, beta-hydroxybutyrate and acetoacetate on acute seizure activity in hippocampal CAl neurons. Epilepsia 1998 39 (8uppl. 6) 35. [Pg.289]

Stafstrom CE, Wang C, Jensen FE. Effects of beta-hydroxybutyrate on epileptiform activity in immature rat hippocampus in vitro. Epilepsia 1999a 40(Suppl. 7) 81. [Pg.290]

Reusch, R.N., and Sadoff, H.L. (1988) Putative structure and function of a poly-beta-hydroxybutyrate/calcium polyphosphate channel in bacterial plasma membranes. Proc. Natl. Acad. Sci. U. S.A., 85,4176-4180. [Pg.269]

Increased urinary excretion of ketones is an indication of perturbations of carbohydrate or impaired fatty acid oxidation. Acetoacetate and beta-hydroxybutyrate are the major compounds appearing in ketosis. [Pg.57]

The liver is the main origin of ketones in laboratory animals, where the long chain fatty acids are released from plasma albumin and bound to fatty acid-binding proteins in the hepatocytes. The long chain fatty acids react with CoA and then can be used to synthesize triacylglycerol or undergo beta-oxidation to acetyl CoA. When the levels of plasma fatty acids are elevated, acetyl CoA can be metabolized to form acetoacetate and 3-hydroxybutyrate or enter the tricarboxylic acid cycle. In ketosis, the levels of acetone, acetoacetate, and 3-hydroxybutyrate (also known as beta-hydroxybutyrate) are increased in both plasma and urine these three compounds historically were collectively called ketone bodies. Urine test strips can be used to test for ketonuria, and there are several enzymatic assays for 3-hydroxybutyrate and acetoacetate. [Pg.193]

Alcoholic ketoacidosis is characterized by anion gap metabolic acidosis and elevated levels of beta-hydroxybutyrate and, to a lesser extent, ace-toacetate. The osmolar gap may also be elevated, causing this condition to be mistaken for methanol or ethylene glycol poisoning. [Pg.192]

B. Other useful laboratory studies include electrolytes, lactate, ethanol, glucose, BUN, creatinine, calcium, hepatic transaminases, urinalysis (for crystals and Wood s lamp examination), measured osmolality, arterial blood gases, and ECG monitoring. Serum beta-hydroxybutyrate levels may help distinguish ethylene glycol poisoning from alcoholic ketoacidosis, which may also cause increased anion and osmolar gaps. (Patients with alcoholic ke-... [Pg.197]

Miller, N. D. and Williams, D. R Biomater. 1987 March, 8(2), 129-137. On the biodegradation of poly-beta-hydroxybutyrate (PHB) homopolymer and poly-beta-hydroxybutyrate-hydrwcyvalerate copolymers. [Pg.37]

Bonartseva, G. A. et al. Aerobic and anaerobic microbial degradation of poly-beta-hydroxybutyrate produced by Azotobacter chroococcum. Appl. Biochem. Biotechnol. [Pg.39]

Kramp, B. et al. [Poly-beta-hydroxybutyric acid (PHB) films and plates in defect covering of the osseus skuU in a rabbit model]. Laryngorhinootologie. 2002, 81(5), 351-356, [Article in German]. [Pg.39]

Ostle AG, Holt JG (1982) Nile blue A as a fluorescent stain for poly-beta-hydroxybutyrate. Appl Environ Microbiol 44 238-241... [Pg.120]

Philip S, Keshavarz T, Roy I (2007) Polyhydroxyalkanoates biodegradable polymers with a range of applications. J Chem Technol Biotechnol 82 233-247 Pierce L, Schroth MN (1994) Detection of pseudomonas colonies that accumulate poly-beta-hydroxybutyrate on Nile blue medium. Plant Dis 78 683-685 Pijuan M, Casas C, Baeza JA (2009) Polyhydroxyalkanoate synthesis using different carbon sources by two enhanced biological phosphorus removal microbial communities. Process Biochem 44 97-105... [Pg.121]

Scandola M, CeccomUi G, Doi Y (1990) Viscoelastic relaxations and thermal properties of bacterial poly(3-hydroxybutyrate-co-3-hydroxyvaleiate) and poly(3-hydroxybutyrate-co-4-hydroxybutyrate). Int J Biol Macromol 12 112—117 Scharlemann JPW, Laurance WF (2008) How green are biofuels Sdence 319 43-44 Senior PJ, Dawes EA (1973) The regulation of poly-beta-hydroxybutyrate metabolism in Azotobacter beiqerinckii. Biochem J 134 225—238 Shah AA, Hasan F, Hameed A (2010) Degradation of poly(3-hydroxybutyrate-co-3-hydroxy-valerate) by a newly isolated Actinomadura sp. AF-555, from sod. Int Biodeterior Biodegrad 64 281-285... [Pg.123]

R.M. Macrae, J.F. Wilkinson, Poly-beta-hydroxybutyrate metabolism in washed suspensions of Bacillus cereus and Bacillus megate-rium, J. Gen. Microbiol. 19 (1) (1958) 210-222. [Pg.120]

J.E. Kemnitzer, S.P. McCarthy, R.A. Gross, Syndiospecific ringopening polymerization of beta-butyrolactone to form predominantly syndiotactic poly (beta-hydroxybutyrate) using tin (TV) catalysts. Macromolecules 26 (23) (1993) 6143-6150. [Pg.120]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...